New evidence in the treatment of diabetic kidney disease: what is finerenone’s contribution?
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Keywords

Finerenone
Diabetic Kidney Disease
Mineralocorticoid Antagonist
Spironolactone
Eplerenone
diabetes mellitus

How to Cite

1.
Fontalvo JR, Daza Arnedo R, Aguilar Salcedo N, Alfaro M, Navas Torrejano D, Cardona Blanco M, Uparella Gulfo I, Raad Sarabia M, Abuabara Franco E, Cabrales J. New evidence in the treatment of diabetic kidney disease: what is finerenone’s contribution?. Rev. Colomb. Nefrol. [Internet]. 2022 Dec. 14 [cited 2024 May 20];9(3). Available from: https://revistanefrologia.org/index.php/rcn/article/view/603

Abstract

Background: Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease (CKD) worldwide and has a direct impact on cardiovascular risk and mortality in patients with diabetes mellitus (DM). Finerenone, a selective mineralocorticoid receptor (MRA) antagonist, has been described in several recent studies as a drug that contributes to slowing the progression of CKD and reducing cardiovascular risk, with an adequate safety profile.

Purpose: To carry out a review of the literature on the impact of finerenone on the progression of renal damage and cardiovascular risk in patients with DKD.

Methodology: A systematic search were carried out in various sources: PubMed (Medline, United States Library of Congress), Science Direct, Scopus, Embase and Lilacs; the search was restricted to references in Spanish and English, with no limits on publication date. The following keywords in the English language were used: diabetic renal disease, chronic kidney disease, diabetes mellitus, spironolactone, eplerenone, finerenone, mineralocorticoid receptor antagonist and their corresponding Spanish versions. 

Results: The references found in the search were reviewed among the different authors to subsequently proceed to prepare the document.

Conclusions: Finerenone is a drug that provides cardio and nephroprotection in patients with DKD albuminuric phenotype.

 

https://doi.org/10.22265/acnef.9.3.603
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