Additional Considerations in the Treatment of Diabetic Nephropathy Based on the KDOQI Clinical Practice Guideline


Diabetes Mellitus
Diabetic Nephropathies
risk factors.
Kidney Diseases

How to Cite

Rico Fontalvo J, Montejo Hernández JD, Daza Arnedo R, Cabrales J. Additional Considerations in the Treatment of Diabetic Nephropathy Based on the KDOQI Clinical Practice Guideline . Rev. Colomb. Nefrol. [Internet]. 2022 Oct. 26 [cited 2024 Jul. 18];9(3). Available from:


Obesity is a risk factor for the development and progression of CKD, which has been shown in numerous studies. The mechanism of how this occurs is not completely understood, but several putative mechanisms proposed via adiposity, include low adiponectin high leptin and resistin, causing inflammation, insulin resistance, RAAS activation and oxidative stress, leading to CKD; in addition, it also causes diabetes mellitus, hypertension, and cardiovascular disease. Obesity is a persistent inflammatory state, and inflammation has been shown to play an important role in the development and progression of diabetic kidney disease, hence controlling obesity has become a key component as a preventative strategy in the development of kidney disease.


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