Urinary proteome in diabetic kidney disease: state of the art
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Diabetic Nephropathies
Mellitus diabetes

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Rico JRF, Daza Anedo R, Raad Sarabia M, Pájaro Galvis N, Bello Espinosa A, Isabella, Pérez Calvo C, Pomares Lara A, Mondol Almeida Z, Vergara Serpa O, Berrocal Martinez C, Collazos Torres LA, Ruiz Pastrana K. Urinary proteome in diabetic kidney disease: state of the art: Proteoma urinario en la enfermedad renal diabética. Estado del arte. Rev. Colomb. Nefrol. [Internet]. 2021 Aug. 18 [cited 2024 Jul. 25];8(3):e546. Available from: https://revistanefrologia.org/index.php/rcn/article/view/546


Diabetic kidney disease (DKD) is the main microvascular complication in patients with diabetes mellitus; it is an entity that generates a significant increase in mortality of cardiovascular origin in this group of patients, although its early diagnosis has a significant impact on the evolution to end-stage kidney disease and, therefore, on mortality. The detection of albuminuria in urine and the deterioration of the estimated glomerular filtration rate are the main diagnostic techniques that are used in clinical practice to establish the presence of DKD; however, they have limitations and therefore it is important to note that kidney damage is usually irreversible once they are present. Over the last few years, numerous studies have focused on the discovery of new biomarkers to detect DKD and this is where the urinary proteomics appears as a new tool, an emerging technology that allows the identification of proteins in a urine sample that strongly suggest the early presence of this disease. Likewise, the discovery of proteomic-based biomarkers represents a novel strategy to improve the diagnosis, prognosis, and treatment of diabetic nephropathy; however, proteomics-based approaches are not yet available in the majority of clinical chemistry laboratories.

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