Proteoma urinario en la enfermedad renal diabética. Estado del arte
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Palabras clave

proteoma
nefropatías diabéticas
diabetes mellitus

Cómo citar

1.
Rico Fontalvo JE, Daza Anedo R, Raad Sarabia M, Pájaro Galvis N, Bello Espinosa A, Uparella Gulfo I, Pérez Calvo C, Pomares Lara A, Mondol Almeida Z, Vergara Serpa O, Berrocal Martinez C, Collazos Torres LA, Ruiz Pastrana K. Proteoma urinario en la enfermedad renal diabética. Estado del arte: Urinary proteome in diabetic kidney disease: state of the art. Rev. Colomb. Nefrol. [Internet]. 18 de agosto de 2021 [citado 21 de octubre de 2021];8(3):e546. Disponible en: https://revistanefrologia.org/index.php/rcn/article/view/546

Resumen

La enfermedad renal diabética (ERD) es la principal complicación microvascular de los pacientes con diabetes mellitus; esta es una entidad que genera un aumento significativo en la mortalidad de origen cardiovascular de este grupo de pacientes, aunque su diagnóstico temprano impacta de forma significativa en la evolución a enfermedad renal terminal y, por lo tanto, en la mortalidad. La detección de albuminuria en la orina y el deterioro de la tasa de filtración glomerular estimada son las principales técnicas diagnósticas que se utilizan en la práctica clínica para establecer la presencia de ERD; sin embargo, estas tienen limitaciones y por lo tanto es importante resaltar que el daño renal suele ser irreversible una vez están presentes. Durante los últimos años, numerosos estudios se han enfocado en detectar nuevos biomarcadores para detectar ERD y es aquí donde aparece como nueva herramienta la proteómica urinaria, una tecnología emergente que permite identificar en una muestra de orina proteínas que sugieren la presencia de esta enfermedad de manera temprana. Asimismo, el descubrimiento de biomarcadores basados en proteómicos representa una estrategia novedosa para mejorar el diagnóstico, pronóstico y tratamiento de la nefropatía diabética; sin embargo, los enfoques basados en la proteómica aún no están disponibles en la mayoría de los laboratorios de química clínica

https://doi.org/10.22265/acnef.8.3.546
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