Current considerations of antimalarials in SARS-COV-2 infection and its impact.
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Keywords

COVID-19, SARS-Cov-2, Kidney Disease, Cardiovascular Disease, Chloroquine, Antiviral Agents, Coronavirus, Coronavirus Infections (MeSH source).

How to Cite

1.
Abuabara-Franco E, Bohórquez-Rivero J, Restom-Arrieta J, Sáenz-López J, Correa-Guerrero J, Mendoza-Paternina C. Current considerations of antimalarials in SARS-COV-2 infection and its impact. Rev. Colomb. Nefrol. [Internet]. 2020 Apr. 23 [cited 2024 Apr. 19];7(Supl.2). Available from: https://revistanefrologia.org/index.php/rcn/article/view/406

Abstract

The compromise of the respiratory and digestive system in patients infected with the new emerging coronavirus becomes apparent. However, there may also be compromise of other important systems, such as the kidney system. It is essential that the clinician does not forget that renal patients often concomit with cardiovascular diseases, since in both pathologies the prognosis of infected-contagious disease caused by the nobel coronavirus becomes bleak. There are still no effective and approved drugs to deal with this virus. Today, the possible beneficial effect of antimalarials (hydroxychloroquine and chloroquine) in the treatment of patients infected with the virus is presumed. It is hoped that through the antiviral properties exhibited by these drugs, the prognosis and mortality associated with this disease will be improved. To this end, a considerable number of trials are advanced that scrutinize and discuss its usefulness in the pathology of current interest.

https://doi.org/10.22265/acnef.7.Supl.2.406
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References

Calvo C, García M, de Carlos J, Vázquez J, et al. Recomendaciones sobre el manejo clínico de la infección por el «nuevo coronavirus» SARS-CoV2. Grupo de trabajo de la Asociación Española de Pediatría (AEP). An Pediatr (Barc); 2020. DOI: https://doi.org/10.1016/j.anpedi.2020.02.001

de Francismo ALM, Canga, P. Coronavirus y Riñón. Nefrología al día [Internet]. 24 de Marzo de 2020. Available at: https://www.nefrologiaaldia.org/es-articulo-coronavirus-rinon-287

Trilla, A. One world, one health: The novel coronavirus COVID-19 epidemic. Medicina Clinica. 2020; 154(5), 175–177. DOI: https://doi.org/10.1016/j.medcli.2020.02.002

WHO. WHO Director-General's opening remarks at the media briefing on COVID-19 .11 March 2020. Available at: https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020

World do meter [Internet]. Coronavirus Updates. [Access: 30 March 2020]. Available at: https://www.worldometers.info/coronavirus/

Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. The Lancet. 2020; 6736(20), 1–10. DOI: https://doi.org/10.1016/S0140-6736(20)30251-8

Clerkin K, Fried J, Raikhelkar J, Sayer G, Griffin J, Masoumi A, et al. Coronavirus Disease 2019 (COVID-19) and Cardiovascular Disease. CIRCULATIONAHA.120.046941. 2020; DOI: https://doi.org/10.1161/CIRCULATIONAHA.120.046941

Gallego A, Remolina S, Mendez I, Pérez O. A propósito del Coronavirus- COVID 19 ¿Qué pasa con el sistema cardiovascular? Sociedad colombiana cardiología y cirugía cardiovascular. PUESTA AL DÍA EN CARDIOLOGÍA. 13 de Marzo de 2020. Boletín 139. Available at: https://scc.org.co/boletin-no-139/

Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. Published online February 24, 2020. DOI: https://doi.org/10.1001/jama.2020.2648

Gautret P, Lagier J, Parola P, Hoang V, Meddeb L, Mailhe M, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial, International Journal of Antimicrobial Agents; 2020. DOI: https://doi.org/10.1016/j.ijantimicag.2020.105949

Colson P, Rolain J, Raoult D. Chloroquine for the 2019 novel coronavirus. International Journal of Antimicrobial Agents; 2020. DOI: https://doi.org/10.1016/j.ijantimicag.2020.105923

Colson P, Rolain J, Lagier J, Brouqui P, Raoult D. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19, International Journal of Antimicrobial Agents; 2020. DOI: https://doi.org/10.1016/j.ijantimicag.2020.105932

Cortegiani A, Ingoglia D, Ippolito M, Giarratano A, Einav S. A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19, Journal of Critical Care; 2020. DOI: https://doi.org/10.1016/j.jcrc.2020.03.005

Gurwitz D. Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics. Drug Dev Res. 4 March 2020 DOI: https://doi.org/10.1002/ddr.21656

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet 2020; DOI: https://doi.org/10.1016/s0140-6736(20)30183-5

Li Z, Wu M, Yao J, Guo J, Liao X, Song S, et al. Caution on Kidney Dysfunctions of 2019-nCoV Patients medRxiv; 2020. DOI: https://doi.org/10.1101/2020.02.18.20023242

Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L, et al. Kidney impairment is associated with in-hospital death of COVID-19 patients. MedRxiv; 2020. DOI: https://doi.org/10.1101/2020.02.18.20023242

Hoffmann M, Kleine-Weber H, Krüger N, Müller M, Drosten C, Pöhlmann S. The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells. Biorxiv 2020. DOI: https://doi.org/10.1101/2020.01.31.929042

Deng Y, Zheng Y, Cai G, Chen X, Hong Q. Single-cell RNA sequencing data suggest a role for angiotensinconverting enzyme 2 in kidney impairment in patients infected with 2019-nCoV. Chinese Medical Journal; 2020. DOI: https://doi.org/10.1097/CM9.0000000000000783

Medina F. Precisions on the history of quinine. Reumatol Clin. 2007; 3(4) :194-6. Available at: https://www.reumatologiaclinica.org/es-pdf-S2173574307702460

Kouznetsov V, Amado D. Antimaláricos: construcción de híbridos moleculares de la cloroquina. Univ. Sci. 2008; 13 (3), 306-320. Available at: https://revistas.javeriana.edu.co/index.php/scientarium/article/view/1442

Amurrio D. La quinina. Historia y Síntesis. Acta Nova. 2001; 1(3): 241-247 Available at: http://ucbconocimiento.ucbcba.edu.bo/index.php/RAN/article/view/171/140

Devaux C, Rolain J, Colson P, Raoult D. New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?. International Journal of Antimicrobial Agents; 2020. DOI: https://doi.org/10.1016/j.ijantimicag.2020.105938

Sahraei Z, Shabani M, Shokouhi S, Saffaei A. Aminoquinolines Against Coronavirus Disease 2019 (COVID-19): Chloroquine or Hydroxychloroquine. International Journal of Antimicrobial Agents; 2020. DOI: https://doi.org/10.1016/j.ijantimicag.2020.105945

Zhou D, Dai SM, Tong Q. COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression. J Antimicrob Chemother; 2020. DOI: https://doi.org/10.1093/jac/dkaa114

Touret, F., & de Lamballerie, X. Of chloroquine and COVID-19. Antiviral Research. 2020; 177 104762. DOI: https://doi.org/10.1016/j.antiviral.2020.104762

Yao X, Ye F, Zhang M, Cui C, Huang B, Niu P, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clinical Infectious Diseases; 2020. DOI: https://doi.org/10.1093/cid/ciaa237

Liu J, Cao R, Xu M, Wang X, Zhang H, Hu H, et al. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discovery. 2020; 6(1), 16. DOI: https://doi.org/10.1038/s41421-020-0156-0

Hu T, Frieman M, Wolfram J. Insights from nanomedicine into chloroquine efficacy against COVID-19. Nature Nanotechnology. 2020; 19–21. DOI: https://doi.org/10.1038/s41565-020-0674-9

Danza Á, Graña D, Goñi M, Vargas A, Ruiz G. (2016). Hydroxychloroquine for autoimmune diseases. Rev Med Chile; 144(2), 232–240. DOI: https://doi.org/10.4067/S0034-98872016000200012

Bohórquez J, Rivera M, Rivera S, Alvear S, Lavalle C. Leptina y su participación en la Enfermedad Arterial Coronaria. Archivos de Medicina. 2020; 16 (1), 1-3. DOI: https://doi.org/10.3823/1423

Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research. 2020; 30(3), 269–271. DOI: https://doi.org/10.1038/s41422-020-0282-0

Fiehn C, Ness T, Weseloh C, Specker C, Hadjiski D, Detert J, Krüger K. Sicherheitsmanagement der Therapie mit Antimalariamitteln in der Rheumatologie. Interdisziplinäre Empfehlungen auf der Basis einer systematischen Literaturrecherche. zeitschrift für Rheumatologie; 2020. DOI: https://doi.org/10.1007/s00393-020-00751-0

Aletaha D, Kapral T, Smolen JS. Toxicityprofiles of traditional disease modifying antirheumatic drugs for rheumatoid arthritis. Ann Rheum Dis. 2003; 62 (5): 482–486. DOI: https://doi.org/10.1136/ard.62.5.482

Wolfe F, Marmor MF. Rates and predictors of hydroxychloroquine retinal toxicity in patients with rheumatoid arthritis and systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2010; 62 (6):775–84. DOI: https://doi.org/10.1002/acr.20133

Izmirly PM, Costedoat-Chalumeau N, Pisoni CN, Khamashta MA, Kim MY, Saxena A, et al. Maternal use of hydroxychloroquine is associated with a reduced risk of recurrent anti-SSA/ Ro-antibody-associated cardiac manifestations of neonatal lupus. Circulation. 2012; 126(1):76-82. DOI: https://doi.org/10.1161/CIRCULATIONAHA.111.089268

Freedman A. Annals of the Rheumatic Diseases. 1956; 15 (3) 251257; DOI: https://doi.org/10.1136/ard.15.3.251

Centers for Disease Control and Prevention (CDC). Guidelines for treatment of malaria in the United States. Updated April 2019. Available at: https://www.cdc.gov/malaria/resources/pdf/clinicalguidance.pdf

WHO. World Health Organization. Guidelines for the Treatment of Malaria. 3rd ed. Geneva, Switzerland: World Health Organization. April 2015. Available at: https://www.who.int/malaria/publications/atoz/9789241549127/en/

Smolen JS, Landewé R, Breedveld FC, Buch M, Burmester G, Dougados M, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update. Ann Rheum Dis. 2014;73(3):492-509.DOI: https://doi.org/10.1136/annrheumdis-2013-204573

Tsang-A-Sjoe MW, Bultink IE. Systemic lupus erythematosus: review of synthetic drugs. Expert Opin Pharmacother. 2015;16(18):2793-2806. DOI: https://doi.org/10.1517/14656566.2015.1101448

Kruize AA, Hené RJ, Kallenberg CG, van Bijsterveld OP, van der Heide A, Kater L, et al. Hydroxychloroquine treatment for primary Sjögren's syndrome: a two year double blind crossover trial. Ann Rheum Dis. 1993;52(5):360-364. DOI: https://doi.org/10.1136/ard.52.5.360

Carsons SE, Vivino FB, Parke A, Carteron, N, Sanka V, Brasington R, et al. Treatment guidelines for rheumatologic manifestations of Sjögren's syndrome: use of biologic agents, management of fatigue, and inflammatory musculoskeletal pain. Arthritis Care Res (Hoboken). 2017; 69(4):517-527. DOI: https://doi.org/10.1002/acr.22968

Miller ML. Initial treatment of dermatomyositis and polymyositis in adults. In: Curtis MR, Ofori AO, (Eds): UpToDate, Post TW (Ed), UpToDate, Waltham, MA. July 2019. Available at: https://www.uptodate.com/contents/initial-treatment-of-dermatomyositis-and-polymyositis-in-adults

Delogu I, de Lamballerie X. Chikungunya disease and chloroquine treatment. Journal of Medical Virology. 2011; 83(6), 1058–1059. DOI: https://doi.org/10.1002/jmv.22019

Paton NI, Lee L, Xu Y, Ooi EE, Cheung YB, Archuleta S, et al. (Chloroquine for influenza prevention: a randomised, double-blind, placebo controlled trial. The Lancet Infectious Diseases. 2011; 11(9), 677–683. DOI: https://doi.org/10.1016/s1473-3099(11)70065-2

Tricou V, Minh NN, Van TP, Lee SJ, Farrar J, Wills B, et al. A randomized controlled trial of chloroquine for the treatment of dengue in Vietnamese adults. PLoS Neglected Trop. Dis. 2010; 4 (8), e785. DOI: https://doi.org/10.1371/journal.pntd.0000785

Mackenzie, A. H. Dose refinements in long-term therapy of rheumatoid arthritis with antimalarials. The American Journal of Medicine. 1983; 75(1), 40-45. DOI: https://doi.org/10.1016/0002-9343(83)91269-x

Alhazzani W, Møller MH, Arabi YM, Loeb M, Gong MN, Fan E. Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19). Intensive Care Medicine; 2020. DOI: https://doi.org/10.1007/s00134-020-06022-5

Consenso colombiano de atención, diagnóstico y manejo de la infección por SARS-COV-2/COVID-19 en establecimientos de atención de la salud - Recomendaciones basadas en consenso de expertos e informadas en la evidencia. Infectio. Marzo de 2020; 24(3):1-102. DOI: https://doi.org/10.22354/in.v24i3.851

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