Abstract
Non-caloric artificial sweeteners have emerged to offer a safe and healthy option in the framework of
food. They have received special attention in recent decades, precisely because of the current food cul-
ture, where fast food and high sugar consumption have taken on special strength, which has a negative
impact on the incidence of metabolic diseases. In that order of ideas, non-caloric artificial sweeteners
propose better health without the need for a drastic change in lifestyle. However, its benefits have not
been studied in depth, in addition to the fact that there has been no significant change in the deve-
lopment of metabolic diseases associated with sugar consumption, on the contrary, they have been
related to diseases such as obesity, type 2 diabetes mellitus and metabolic syndrome. Likewise, they
cause a series of metabolic changes by different mechanisms that end in progressive proteinuria and a
decrease in the glomerular filtration rate. In order with the above, an analysis of the risk to which one
is subjected when choosing this food option is necessary, and not be deafened, much less dazzled by
the media processes, if not rather, be governed by scientific findings.
References
Durán S, Cordón K, Rodríguez M del P. Edulcorantes no nutritivos, riesgos, ape-tito y ganancia de peso. Rev Chil Nutr. 2013;40(3):309-14. http://dx.doi.org/10.4067/S0717-75182013000300014
Stephens-Camacho NA, Valdez-Hurtado S, Lastra-Zavala G, Félix-Ibarra LI. Consumode edulcorantes no nutritivos: efectos a nivel celular y metabólico. Perspect Nut Hum.2018;20(2):185-202. https://doi.org/10.17533/udea.penh.v20n2a06
Risdon S, Meyer G, Marziou A, Riva C, Roustit M, Walther G. Articial sweeteners impairendothelial vascular reactivity: Preliminary results in rodents. Nutr Metab Cardiovasc Dis.2020;30(5):843-6. https://doi.org/10.1016/j.numecd.2020.01.014
Pearlman M, Obert J, Casey L. The Association Between Artificial Sweeteners and Obe-sity. Curr Gastroenterol Rep. 2017;19(12):64. https://doi.org/10.1007/s11894-017-0602-
Chattopadhyay S, Raychaudhuri U, Chakraborty R. Artificial sweeteners - A review. J FoodSci Technol. 2014;51(4):611-21. https://doi.org/10.1007/s13197-011-0571-1
Bueno-Hernández N, Vázquez-Frías R, Abreu y Abreu AT, Almeda-Valdés P, Barajas-NavaLA, Carmona-Sánchez RI,et al. Review of the scientific evidence and technical opinionon noncaloric sweetener consumption in gastrointestinal diseases. Rev Gastroenterol Mex.2019;84(4):492-510. https://doi.org/10.1016/j.rgmx.2019.08.001
Aldrete-Velasco J, López-García R, Zúñiga-Guajardo S, Riobó-Serván P, Serra-MajemL, Suverza-Fernández A,et al. Análisis de la evidencia disponible para el consumo de edulcorantes no calóricos. Documento de expertos. Med Interna Mex. 2017 [citado abril 22 2021];33(1):61-83. Disponible en: http://www.scielo.org.mx/pdf /mim/v33n1/0186-4866-mim-33-01-00061.pdf
Mooradian AD, Smith M, Tokuda M. The role of artificial and natural sweeteners in re-ducing the consumption of table sugar: A narrative review. Clin Nutr ESPEN. 2017;18:1-8.http://dx.doi.org/10.1016/j.clnesp.2017.01.004
Sylvetsky A, Rother KI, Brown R. Articial sweetener use among children: Epidemiology,recommendations, metabolic outcomes, and future directions. Pediatr Clin North Am.2011;58(6):1467-80. http://dx.doi.org/10.1016/j.pcl.2011.09.007
Sylvetsky AC, Blau JE, Rother KI. Understanding the metabolic and health effects of low-calorie sweeteners: methodological considerations and implications for future research. RevEndocr Metab Disord. 2016;17(2):187-94. http://dx.doi.org/10.1007/s11154-016-9344-5.
García-Almeida JM, Casado Fernadez Gracia M, García-Alemán J. Una visión globaly actual de los edulcorantes: aspectos de regulación. Nutr. Hosp. 2013 [citado abril 222021];28(Suppl 4):17-31. Disponible en: http://scielo.isciii.es/scielo.php?script=sciarttext&pid=S0212-16112013001000003&lng=es
Tollefsen KE, Nizzetto L, Huggett DB. Presence, fate and effects of the intense sweetenersucralose in the aquatic environment. Sci Total Environ. 2012;438:510-6. http://dx.doi.org/10.1016/j.scitotenv.2012.08.060
Cavagnari BM. Non-caloric sweeteners: specic characteristics and safety assessment.Arch Argent Pediatr. 2019;117(1):e1-e7. http://dx.doi.org/10.5546/aap.2019.eng.e1
Kumar PA, Chitra PS, Reddy GB. Metabolic syndrome and associated chronic kidneydiseases: Nutritional interventions. Rev Endocr Metab Disord. 2013;14(3):273-86. http://dx.doi.org/10.1007/s11154-013-9268-2
Swithers SE. Articial sweeteners produce the counterintuitive effect of inducing meta-bolic derangements. Trends Endocrinol Metab [Internet]. 2013;24(9):431- 41. https://doi.org/10.1016/j.tem.2013.05.005
Pepino MY. Metabolic effects of non-nutritive sweeteners. Physiol Behav. 2015;152(PtB):450-5. https://doi.org/10.1016/j.physbeh.2015.06.024
Manzur-Jattin F, Morales-Núñez M, Ordosgoitia-Morales J, Quiroz-Mendoza R, Ramos-Villegas Y, Corrales-Santander H. Impacto del uso de edulcorantes no calóricos en la salud cardiometabólica. Revista Colombiana de Cardiología. 2020;27(2):103-8. https://doi.org/10.1016/j.rccar.2019.11.003
Burke MV, Small DM. Physiological mechanisms by which non-nutritive sweeteners mayimpact body weight and metabolism. Physiol Behav. 2015;152(Pt B):381-8. https://doi.org/10.1016/j.physbeh.2015.05.036
Swithers SE. Artificial sweeteners are not the answer to childhood obesity. Appetite.2015;93:85-90. https://doi.org/10.1016/j.appet.2015.03.027
Bomback AS, Katz R, He K, Shoham DA, Burke GL, Klemmer PJ. Sugar- sweetened be-verage consumption and the progression of chronic kidney disease in the Multi-EthnicStudy of Atherosclerosis (MESA). Am J Clin Nutr. 2009;90(5):1172-8. https://doi.org/10.3945/ajcn.2009.28111
Cheungpasitporn W, Thongprayoon C, O’Corragain OA, Edmonds PJ, Kittanamong-kolchai W, Erickson SB. Associations of sugar-sweetened and artificially sweetened sodawith chronic kidney disease: a systematic review and meta-analysis. Nephrology (Carlton).2014;19(12):791-7. https://doi.org/10.1111/nep.12343.
Saldana TM, Basso O, Darden R, Sandler DP. Carbonated beverages and chronic kid-ney disease. Epidemiology. 2007;18(4):501-6. https://doi.org/10.1097/EDE.0b013e3180646338
Lin J, Curhan GC. Associations of sugar and artificially sweetened soda with albuminuriaand kidney function decline in women. Clin J Am Soc Nephrol. 2011;6(1):160-6. https://doi.org/10.2215/CJN.03260410
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.