Abstract
We have read with great interest the article by Braunwald (1) entitled Gliflozins in the management of cardiovascular disease, recently published in the New England Journal of Medicine, where the author provides an excellent review of SGLT2 inhibitors (iSGLT2) and their effects at the cardiovascular level; however, we consider it relevant to clarify certain points in this regard.
References
Braunwald E. Gliflozins in the management of cardiovascular disease. N Engl J Med 2022;386:2024-2034. https://doi.org/10.1056/NEJMra2115011
Heerspink HJL, Stefánsson BV, Correa-Rotter R, Chertow GM, Greene T, Hou FF, et al. Dapagliflozin in Patients with Chronic Kidney Disease. N Engl J Med. 2020;383(15):1436-1446. https://doi.org/10.1056/NEJMoa2024816
Perkovic V, Jardine MJ, Neal B, Bompoint S, Heerspink HJL, Charytan DM, et al. Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy. N Engl J Med. 2019;380(24):2295-2306. https://doi.org/10.1056/NEJMoa1811744

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