Focal segmental glomerulosclerosis of collapsing variant associated with HIV
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renal insufficiency
kidney diseases
antiretroviral agents

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Amador Canals AC, Agresott Mancera EC, Caicedo Mesa A, Aborashed Amador NF, Vargas Rodríguez LJ, Andrade Pérez RE. Focal segmental glomerulosclerosis of collapsing variant associated with HIV: Glomeruloesclerosis focal segmentaria de variante colapsante asociada a VIH. Rev. Colomb. Nefrol. [Internet]. 2020 Nov. 20 [cited 2024 Apr. 20];8(1):e514. Available from:


Human immunodeficiency virus infection has changed after the start of highly active antiretroviral treatment, generating greater survival and fewer patient comorbidities. In these patients, the finding of acute renal failure is common, which may be associated with sepsis, drug toxicity, or direct involvement by the virus itself. Nephropathy in patients with HIV infection is varied, where it can be associated with the use of medications or directly due to the effect of the virus (HIVAN). The prevalence is less than 10 \% and is characterized by glomerular collapse. Renal parenchyma cells express the chemokine receptors CCR5 and CXCR4 that are essential for the entry of HIV-1 strains into cells. The present case is interesting, since acute renal failure in the framework of a nephrotic syndrome was the first manifestation of a patient with HIV / AIDS.
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