Glomeruloesclerosis focal segmentaria de variante colapsante asociada a VIH

Focal segmental glomerulosclerosis of collapsing variant associated with HIV

Autores/as

DOI:

https://doi.org/10.22265/acnef.8.1.514

Palabras clave:

VIH, insuficiencia renal, nefropatía, antirretrovirales

Resumen

La afectación del virus de la inmunodeficiencia humana (VIH) ha cambiado tras el inicio del tratamiento antirretroviral de gran actividad, ya que este ha generado una mayor supervivencia y un menor número de comorbilidades en los pacientes. Es común que en las personas con VIH el fracaso renal agudo esté asociado a sepsis, toxicidad por fármacos o afección directa por el propio virus. La nefropatía en pacientes con VIH es variada y puede estar asociada al uso de medicamentos o directamente al efecto del virus. La prevalencia de esta patología en este tipo de pacientes es <10 % y se caracteriza por un colapso glomerular. Las células del parénquima renal expresan los receptores de quimiocinas CCR5 y CXCR4, que son esenciales para la entrada de cepas de VIH-1 en las células. El presente caso es particularmente interesante ya que la insuficiencia renal aguda en el marco de un síndrome nefrótico fue la primera manifestación en un paciente con VIH/sida.

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Publicado

2020-11-20

Cómo citar

1.
Amador Canals AC, Agresott Mancera EC, Caicedo Mesa A, Aborashed Amador NF, Vargas Rodríguez LJ, Andrade Pérez RE. Glomeruloesclerosis focal segmentaria de variante colapsante asociada a VIH: Focal segmental glomerulosclerosis of collapsing variant associated with HIV. Rev. Colomb. Nefrol. [Internet]. 20 de noviembre de 2020 [citado 22 de septiembre de 2021];8(1):e514. Disponible en: https://revistanefrologia.org/index.php/rcn/article/view/514

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