Nephrological conditions, manifestations and repercussions of COVID-19
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Coronavirus 2019; Renal insufficiency; kidney; renal; kidney injury; repercussions.

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Amador Cannals AC, Vargas Rodríguez LJ, Rodríguez Mongui DA, Aborashed Amador NF, Rozo Ortiz EJ. Nephrological conditions, manifestations and repercussions of COVID-19. Rev. Colomb. Nefrol. [Internet]. 2021 Mar. 4 [cited 2024 Jul. 16];8(2):e490. Available from:


Introduction: Coronavirus disease (COVID - 19) emerged in Wuhan, China at the end of 2019, this is a microorganism that, due to its genome sequencing and phylogenic analysis, belongs to the group of betacoronavirus in the same subgenus as the severe acute respiratory syndrome virus (SARS). The objective of the present study is to determine the renal affections and manifestations of patients with SARS CoV-2 infection.

Methods: A review of the literature was carried out, including studies evaluating renal conditions, manifestations and repercussions in patients older than 18 years with COVID-19 infection.

Results: A total of 24 studies were included where the different renal conditions of these patients were mentioned. At the microscopic level, there are different alterations such as loss of the brush border, vacuolar degeneration, dilation of the tubular lumen with cellular remains and sometimes frank necrosis in the proximal tubules, epithelial detachment of the tubular basement membrane and acute pyelonephritis with multiple bacterial foci. and diffuse polymorphonuclear cell (PMN) cylinders in the tubules. At the glomerulus level, nodular mensangial expansion and the presence of abundant erythrocytes obstructing the peritubular capillary lumens were observed.

Conclusions: SARS-CoV-2 is a virus that has high affinity for Angiotensin II Converting Enzyme (ACE) receptors -2), which are found in different organs of the body, including the kidneys. The binding of the virus to this receptor will lead to different microscopic alterations in the renal cells, which will generate some important disorders such as hydro-electrolyte alterations, elevation or increase in serum creatinine, being an indicator of acute kidney injury that in some cases can become chronic in these patients.
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1. Thompson R. Pandemic potential of 2019-nCoV. Lancet Infect Dis [Internet]. 2020 Mar 1 [cited 2020 Apr 5];20(3):280. Available from:
2. Zhou P, Yang X Lou, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature [Internet]. 2020 Mar 12 [cited 2020 Apr 5];579(7798):270–3. Available from:
3. Gorbalenya AE. Severe acute respiratory syndrome-related coronavirus – The species and its viruses, a statement of the Coronavirus Study Group. bioRxiv [Internet]. 2020 Feb 11 [cited 2020 Apr 5];2020.02.07.937862. Available from:
4. Schoeman D, Fielding BC. Coronavirus envelope protein: Current knowledge. Virol J [Internet]. 2019 May 27 [cited 2020 Apr 5];16(1):1–22. Available from:
5. OMS Organización mundial de la salud. Alocución de apertura del Director General de la OMS en la rueda de prensa sobre la COVID-19 celebrada el 11 de marzo de 2020 [Internet]. 2020 [cited 2020 Apr 5]. Available from:
6. Enfermedades C para el C y la P de. Personas que corren un mayor riesgo de enfermedad grave | Centros para el Control y la Prevención de Enfermedades [Internet]. CDC. 2020 [cited 2020 Apr 5]. Available from:
7. Yuxia Cui, Maolu Tian, Dong Huang, Xike Wang, Yuying Huang, Li Fan, Liang Wang, Yun Chen, Wenpu Liu, Kai Zhang, Yue Wu, Zhenzhong Yang, Jing Tao, Jie Feng, Kaiyu Liu, Xianwei Ye, Rongpin Wang, Xiangyan Zhang YZ. 55-Day-Old Female Infant Infected With 2019 Novel Coronavirus Disease: Presenting With Pneumonia, Liver Injury, and Heart Damage | The Journal of Infectious Diseases | Oxford Academic. J Infect Dis [Internet]. 2020 [cited 2020 Apr 5]; Available from:

8. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet [Internet]. 2020 [cited 2020 Apr 5];395(10229). Available from:
9. OMS Organización mundial de la salud. Coronavirus (CoV) GLOBAL [Internet]. OMS. 2020 [cited 2020 Apr 5]. Available from:
10. Wu Y, Xu X, Chen Z, Duan J, Hashimoto K, Yang L, et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun [Internet]. 2020 Mar 30 [cited 2020 Apr 5]; Available from:

11. Sanchis-Gomar F, Lavie CJ, Perez-Quilis C, Henry BM, Lippi G. Angiotensin-Converting Enzyme 2 and Antihypertensives (Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors) in Coronavirus Disease 2019. Mayo Clin Proc. 2020;
12. Naicker S, Yang CW, Hwang SJ, Liu BC, Chen JH, Jha V. The Novel Coronavirus 2019 epidemic and kidneys. Kidney Int. 2020;1–5.
13. Alsaad K, Arabi Y, Hajeer A. Spectrum of histopathological findings in coronavirus disease?19, Middle East respiratory syndrome and severe acute respiratory syndrome. Ann Thorac Meedicine. 2020;15(3):52–3.
14. Kang S, Peng W, Zhu Y, Lu S, Zhou M, Lin W, et al. Recent Progress in understanding 2019 Novel Coronavirus associated with Human Respiratory Disease: Detection, Mechanism and Treatment. Int J Antimicrob Agents. 2020;
15. Su H, Yang M, Wan C, Li Xia Y, Tang F, Zhu HY, et al. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int. 2020;
16. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054–62.
17. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA - J Am Med Assoc. 2020;323(11):1061–9.
18. Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L, et al. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int. 2020;1–10.
19. Volunteers A-2019-nCoV, Li Z, Wu M, Guo J, Yao J, Liao X, et al. Caution on Kidney Dysfunctions of 2019-nCoV Patients. medRxiv. 2020;
20. Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;1–13.
21. Li X, Wang L, Yan S, Yang F, Xiang L, Zhu J, et al. Clinical characteristics of 25 death cases with COVID-19: a retrospective review of medical records in a single medical center, Wuhan, China. Int J Infect Dis. 2020;
22. Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, et al. A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19. N Engl J Med. 2020;1–13.
23. Al-Omari A, Rabaan AA, Salih S, Al-Tawfiq JA, Memish ZA. MERS coronavirus outbreak: Implications for emerging viral infections. Diagn Microbiol Infect Dis. 2019;93(3):265–85.
24. Ren Z-L, Hu R, Wang Z-W, Zhang M, Ruan Y-L, Wu Z-Y, et al. Epidemiological and Clinical Characteristics of Heart Transplant Recipients During the 2019 Coronavirus Outbreak in Wuhan, China: a Descriptive Survey Report. J Hear Lung Transplant. 2020;
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