Patient and Graft Survival in the Elderly Kidney Transplant Recipients
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Keywords

Kidney transplant, graft survival, patient survival, elderly, aging.

How to Cite

1.
Sanchez-Avila Y, Patiño-Jaramillo N, Garcia Lopez A, Giron-Luque F. Patient and Graft Survival in the Elderly Kidney Transplant Recipients. Rev. Colomb. Nefrol. [Internet]. 2021 Feb. 16 [cited 2022 Aug. 11];8(2):e512. Available from: https://revistanefrologia.org/index.php/rcn/article/view/512

Abstract

Background: Kidney transplantation is considered the most effective renal replacement therapy for chronic kidney disease. Recently, kidney transplantation is increasing in elderly recipients. Aged patients who have a kidney transplant have relevant advantages compared to dialysis reported in the literature such as better survival.

Objective: We aimed to assess graft and patient survival in a cohort of elderly kidney transplant recipients.  

Materials and Methods: We retrospectively analyzed a cohort of 193 patients older than 60 years who received a kidney transplant from 2008 to 2019 in our transplant centers. Our study included sociodemographic and clinical variables to determine patient and graft survival at 1, 5 and 10 years after kidney transplantation using the Kaplan-Meier method. Cox regression analysis was used to evaluate the potential risk factors for graft loss during the first year of transplantation. 

Results: The mean recipient age was 64.62 ± 3.82 years old. The 1, 5 and 10-year death-censored graft survival rates were 90%, 86% and 75% and uncensored graft survival probability was 82%, 63% and 43% at 1, 5 and 10 years, respectively. The main mortality causes were infections and cardiovascular disease.  Patient survival was 89%, 70% and 55% at 1, 5 and 10 years, respectively. Independent graft loss risk factors in the first year posttransplant were: age >70 (HR 4.2; 95% CI 1.1-15.3), female sex (HR 2.7; 95% CI 1.01-7.3) and non-compliance (HR 8.1; 95% CI 2.1-30.7).  

Conclusion: We found that older patients experience good outcomes following renal transplantation. There is a need to determine suitable older recipients based on objective selection criteria where age should not be a barrier to the kidney transplant.  

 

https://doi.org/10.22265/acnef.8.2.512
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References

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