Renal and digestive engagement in COVID-19 infections
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Keywords

SARS-CoV-2, COVID-19, kidney diseases, coronavirus infections, gastrointestinal diseases.

How to Cite

1.
Navarro-Quiroz RC, Atencio-Ibarra L, Herrera Usuga JC, Osorio Ospina LM, Navarro Quiroz KF, Potes Rodriguez YC, Gómez Escorcia L, Aroca Martínez G, Navarro-Quiroz E. Renal and digestive engagement in COVID-19 infections. Rev. Colomb. Nefrol. [Internet]. 2020 May 15 [cited 2024 May 20];7(Supl.2). Available from: https://revistanefrologia.org/index.php/rcn/article/view/427

Abstract

Infection with Severe Acute Respiratory Syndrome (SARS-CoV-2) has caused one of the largest epidemiological emergencies in the last 10 years and its pathological effects are still studied. Due to the forementioned, it is important to describe the mechanisms associated with renal and digestive compromise in SARS-CoV-2 infection. The pathological mechanisms in kidney tissue and in the intestine caused by SARS-CoV-2 infection are characteristic of the viral tropism by cells of these systems and of the lymphocytic mechanisms of the lytic stage of the infection, with a continuous release of virions that favors the generation of an inflammatory environment with the consequent uncontrolled secretion of proinflammatory cytokinesthat lead to enteric infection of the intestine and alterationsin the kidney. 

https://doi.org/10.22265/acnef.7.Supl.2.427
PDF (Español)

References

Lu H, Stratton CW, Tang Y. Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle. J Med Virol. 2020 Apr;92(4):401-2. Available from: https://doi.org/10.1002/jmv.25678

Sohrabi C, Alsafi Z, O’Neill N, Khan M, Kerwan A, Al-Jabir A, et al. World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). Int J Surg. 2020 Apr 1;76:71-6. Available from: https://doi.org/10.1016/j.ijsu.2020.02.034

Volunteers A-2019-nCoV, Li Z, Wu M, Yao J, Guo J, Liao X, et al. Caution on Kidney Dysfunctions of COVID-19 Patients. medRxiv. 2020 Mar 27. Available from: https://doi.org/10.1101/2020.02.08.20021212.

Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L, et al. Kidney disease is associated with in-hospital death of patients with COVID19. Kidney Int [Internet]. 2020 Mar 19 [cited 2020 Apr 5];0(0). Available from: https://www.kidney-international.org/article/S0085- 2538(20)30255-6/abstract

Gu J, Han B, Wang J. COVID-19: Gastrointestinal Manifestations and Potential Fecal-Oral Transmission. Gastroenterology. 2020 Mar 3;158(6):1518-9. Available from: https://doi.org/10.1053/j.gastro.2020.02.054

Zhang W, Du R-H, Li B, Zheng X-S, Yang X-L, Hu B, et al. Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. Emerg Microbes Infect. 2020 Jan 1;9(1):386-9. Available from: https://doi.org/10.1080/22221751.2020.1729071

Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, et al. First Case of 2019 Novel Coronavirus in the United States. N Engl J Med. 2020 Mar 5;382(10):929–36. Available from: https://doi.org/10.1056/NEJMoa2001191

Tang A, Tong Z, Wang H, Dai Y, Li K, Liu J, et al. Early Release - Detection of Novel Coronavirus by RT-PCR in Stool Specimen from Asymptomatic Child, China - Volume 26, Number 6-June 2020 - Emerging Infectious Diseases journal - CDC. [cited 2020 Apr 14]; Available from: https://wwwnc.cdc.gov/eid/article/26/6/20- 301_article

Young BE, Ong SWX, Kalimuddin S, Low JG, Tan SY, Loh J, et al. Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore. JAMA [Internet]. 2020 Mar 3 [cited 2020 Apr 14]; Available from: https://jamanetwork.com/journals/jama/ fullarticle/2762688

Chronic Kidney Disease in the United States, 2019 [Internet]. 2019 [cited 2020 Apr 14]. Available from: https://www.cdc.gov/kidneydisease/publications-resources/2019-national-facts.html

Hamming I, Timens W, Bulthuis MLC, Lely AT, Navis GJ, van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol. 2004 Jun;203(2):631-7. Available from: https://doi.org/10.1002/path.1570

Gu J, Korteweg C. Pathology and Pathogenesis of Severe Acute Respiratory Syndrome. Am J Pathol. 2007 Apr;170(4):1136–47. Available from: https://doi.org/10.2353/ajpath.2007.061088

WHO | Frequently asked questions on Middle East respiratory syndrome coronavirus (MERS-CoV) [Internet]. WHO. World Health Organization; [cited 2020 Apr 14]. Available from: http://www.who.int/csr/disease/coronavirus_infections/faq/en/

Wu F, Zhao S, Yu B, Chen Y-M, Wang W, Song Z-G, et al. A new coronavirus associated with human respiratory disease in China. Nature. 2020;579(7798):265-9. Available from: https://doi.org/10.1038/s41586-020-2008-3

Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. The Lancet. 2020 Feb 22;395(10224):565–74. Available from: https://doi.org/10.1016/S0140- 6736(20)30251-8

Huang Q, Herrmann A. Fast assessment of human receptor-binding capability of 2019 novel coronavirus (2019-nCoV). bioRxiv. 2020 Feb 4. Available from: https://doi.org/10.1101/2020.02.01.930537

Zhang H, Kang Z, Gong H, Xu D, Wang J, Li Z, et al. The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes. bioRxiv. 2020 Jan 31; Available from: https://doi.org/ 10.1101/2020.01.30.927806

Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical characteristics of 2019 novel coronavirus infection in China. medRxiv. 2020 Feb 9; Available from: https://doi.org/10.1101/2020.02.06.20020974

Specimen referral for 2019nCoV - operational details of referral laboratories* [Internet]. 2020. Available from: https://www.who.int/docs/default-source/coronaviruse/who-appointed-2019-ncov-referral-laboratories-7-february-2020.pdf?sfvrsn=c3fa3ec3_4

Normile D. Singapore claims first use of antibody test to track coronavirus infections. Science [Internet]. 2020 Feb 27 [cited 2020 Apr 14]; Available from: https://www.sciencemag.org/news/2020/02/singapore-claims-first- se-antibody-test-track-coronavirus-infections

Corman VM, Landt O, Kaiser M, Molenkamp R, Meijer A, Chu DK, et al. Detection of 2019 novel coronavirus (2019-nCoV) by realtime RT-PCR. Eurosurveillance [Internet]. 2020 Jan 23 [cited 2020 Apr 14];25(3). Available from: https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC6988269/

Chan JF-W, Yip CC-Y, To KK-W, Tang TH-C, Wong SC-Y, Leung K-H, et al. Improved molecular diagnosis of COVID-19 by the novel, highly sensitive and specific COVID-19-RdRp/Hel real-time reverse transcription-polymerase chain reaction assay validated in vitro and with clinical specimens. J Clin Microbiol. 2020 Mar 4; Available from: https://doi.org/10.1128/JCM.00310-20

Cheng VCC, Lau SKP, Woo PCY, Yuen KY. Severe Acute Respiratory SyndromeCoronavirus as an Agent of Emerging and Reemerging Infection. Clin Microbiol Rev. 2007 Oct;20(4):660–94. Available from: https://doi.org/10.1128/CMR.00023-07

Chan JFW, Lau SKP, To KKW, Cheng VCC, Woo PCY, Yuen K-Y. Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease. Clin Microbiol Rev. 2015 Apr;28(2):465-522. Available from: https://doi.org/10.1128/ CMR.00102-14

Spagnuolo G, De Vito D, Rengo S, Tatullo M. COVID-19 Outbreak: An Overview on Dentistry. Int J Environ Res Public Health. 2020 Jan;17(6):2094. Available from: https://doi.org/10.3390/ijerph17062094

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirusin Wuhan, China. The Lancet. 2020 Feb 15;395(10223):497-506. Available from: https://doi.org/10.1016/S0140-6736(20)30183-5

Peiris JSM, Chu CM, Cheng VCC, Chan KS, Hung IFN, Poon LLM, et al. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. The Lancet. 2003 May 24;361(9371):1767-72. Available from: https://doi.org/10.1016/s0140-6736(03)13412-5

Valizadeh R, Baradaran A, Mirzazadeh A, Bhaskar LV. Coronavirus-nephropathy; renal involvement in COVID-19. J Renal Inj Prev. 2020; 9(2): e18. Available from: https://doi.org/10.34172/jrip.2020.18

Pertuz SI, Aroca-Martinez G, Verbel M de los AV, Osorio AC, Cadena-Bonfanti A, Correa-Monterrosa M, et al. Reporte de 4 casos COVID-19 hospitalizados en unidad de cuidados intensivos en una institución hospitalaria en Barranquilla, Colombia. Rev Colomb Nefrol [Internet]. 20 [cited 2020 Apr 14];7(Supl 2). Available from: https://revistanefrologia.org/index.php/rcn/article/view/420

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus– Infected Pneumonia in Wuhan, China. JAMA. 2020 Mar 17;323(11):1061–9. Available from: https://doi.org/10.1001/jama.2020.1585

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. 2020 Feb 15;395(10223):507–13. Available from: https://doi.org/10.1016/S0140-6736(20)30211-7

Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med [Internet]. 2020 Feb 28 [cited 2020 Apr 14]; Available from: https://www.nejm.org/doi/10.1056/NEJMoa2002032

Menachery VD, Yount BL, Debbink K, Agnihothram S, Gralinski LE, Plante JA, et al. A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence. Nat Med. 2015 Dec;21(12):1508-13. Available from: https://doi.org/10.1038/nm.3985

Chu KH, Tsang WK, Tang CS, Lam MF, Lai FM, To KF, et al. Acute renal impairment in coronavirus-associated severe acute respiratory syndrome. Kidney Int. 2005 Feb;67(2):698–705. Available from: https://doi.org/https://doi.org/10.1111/j.1523- 1755.2005.67130.x

Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003 Nov;426(6965):450-4. Available from: https://doi.org/10.1038/nature02145

Su H, Yang M, Wan C, Yi L-X, Tang F, Zhu H-Y, et al. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int [Internet]. 2020 Apr 9 [cited 2020 Apr 14];0(0). Available from: https://www.kidney-international.org/ article/S0085-2538(20)30369-0/abstract

Rodríguez EC, Zambrano DP, Cadiñanos PM de L, Osorio LR, Iguacel CG, Egido J, et al. Glomerulonefritis rápidamente progresiva asociada a endocarditis afebril y anca anti-proteinasa 3. Rev Colomb Nefrol. 2017 Mar 29;4(1):85-92. Available from: https://doi.org/10.22265/acnef.4.1.258

Martínez GA, Tolosa RG, Camargo T, Niño LM. Glomerulonefritis por inmunocomplejos tipo lupus–like asociada a VIH: a propósito de un caso y revisión de la literatura. Rev Colomb Nefrol [Internet]. 2014 [cited 2020 Apr 14];1. Available from: https://revistanefrologia.org/index.php/rcn/article/view/140

Ma Y, Diao B, Lv X, Zhu J, Liang W, Liu L, et al. 2019 novel coronavirus disease in hemodialysis (HD) patients: Report from one HD center in Wuhan, China. medRxiv. 2020 Feb 27. Available from: https://doi.org/10.1101/2020.02.24.20027201

Izzedine H, Jhaveri KD, Perazella MA. COVID-19 therapeutic options for patients with Kidney Disease. Kidney Int [Internet]. 2020 Mar 30 [cited 2020 Apr 14];0(0). Available from: https://www.kidney-international.org/article/S0085-2538(20)30349-5/abstract

Chan JF-W, Yuan S, Kok K-H, To KK-W, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. The Lancet. 2020 Feb 15;395(10223):514-23. Available from: https://doi.org/10.1016/S0140-6736(20)30154-9

Xiao F, Tang M, Zheng X, Liu Y, Li X, Shan H. Evidence for Gastrointestinal Infection of SARS-CoV-2. Gastroenterology [Internet]. 2020 Mar 3 [cited 2020 Apr 14];0(0). Available from: https://www.gastrojournal.org/article/S0016-5085(20)30282-1/abstract

Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J, et al. SARS-CoV-2 Infection in Children. N Engl J Med. 2020 Apr 3;382(17):1663-5. Available from: https://doi.org/10.1056/NEJMc2005073

Xu Y, Li X, Zhu B, Liang H, Fang C, Gong Y, et al. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med. 2020 Apr;26(4):502-5. Available from: https://doi.org/10.1038/s41591-020-0817-4

D’Amico F, Baumgart DC, Danese S, Peyrin-Biroulet L. Diarrhea during COVID-19 infection: pathogenesis, epidemiology, prevention and management. Clin Gastroenterol Hepatol [Internet]. 2020 Apr 8 [cited 2020 Apr 14]; Available from: http://www.sciencedirect.com/ science/article/pii/S154235652030481X

Leung WK, To K-F, Chan PKS, Chan HLY, Wu AKL, Lee N, et al. Enteric involvement of severe acute respiratory syndromeassociated coronavirus infection. Gastroenterology. 2003 Oct;125(4):1011-7. Available from: https://doi.org/10.1016/s0016-5085(03)01215-0

Abdullah ASM, TomlinsonB, CockramCS, Thomas GN. Lessons from the Severe Acute Respiratory Syndrome Outbreak in Hong Kong. Emerg Infect Dis. 2003 Sep;9(9):1042-5. Available from: https://doi.org/10.3201/eid0909.030366

Zhou P, Yang X-L, Wang X-G, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020 Mar;579(7798):270–3. Available from: https://doi.org/10.1038/s41586-020-2012-7

Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci. 2020 Feb 24;12(1):1–5. Available from: https://doi.org/10.1038/s41368-020-0074-x

Letko M, Marzi A, Munster V. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Nat Microbiol. 2020 Apr;5(4):562–9. Available from: https://doi.org/10.1038/s41564-020-0688-y

Wan S, Yi Q, Fan S, Lv J, Zhang X, Guo L, et al. Characteristics of lymphocyte subsets and cytokines in peripheral blood of 123 hospitalized patients with 2019 novel coronavirus pneumonia (NCP). medRxiv. 2020 Feb 12. Available from: https://doi.org/10.1101/ 2020.02.10.20021832

Lin L, Lu L, Cao W, Li T. Hypothesis for potential pathogenesis of SARS-CoV-2 infection–a review of immune changes in patients with viral pneumonia. Emerg Microbes Infect. 2020 Jan 1;9(1):727-32. Available from: https://doi.org/10.1080/22221751.2020.1746199

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