Introduction: Primary glomerulonephritis are diseases that affect the structure and function of the glomerulus. For proliferative glomerulopathies, it has been observed that for IgA and IgM mesangial GN, they are the ones that mostly evolve to end-stage renal failure, followed by membranous-proliferative or mesangiocapillar GN. The clinical manifestation of GN is the result of the combination of hematuria, proteinuria and the presence of acute or chronic renal failure.
Material and methods: Medical records were reviewed. They were collected in a database of all biopsies performed from 2008 to 2014. An ?² was used to establish associations between variables (? = 95%). For the differences among proportions Student’s t or U-Mann-Whitney were used.
Results: 146 (88%) patients who had complete data were selected. The mean age was 8 ± 4 years old for both sexes. No significant difference was found between gender by age (p? 0.05), nor was there an association between gender and age (p? 0.05). The predominant NGs with the highest prevalence were Proliferative Mesangial and IgA Nephropathy. NGs by Thin Basal Membrane, Nephropathy by C3 and Cq were not present in male patients. The most prevalent syndromic picture was the Nephrotic Syndrome (58%).
Conclusions: The existence of this registry of renal biopsies is the basis for the creation of the Registry of Glomerulopathies in children in Colombia, whose data are necessary to establish programs for the treatment and prevention of glomerular diseases in our country in order to decrease its progression.
2. Pietrángelo C. Las Glomerulopatías. Enfoque Clínico- atológico. Rev med interna2000;2(4). Available from: http:// www.smiba.org.ar/med_interna/vol_02/03_05.htm
3. Fernández Fresnedo G. Glomerulonefritis primarias. Nefrología al día. p. 23–45.
4. Piña J, Saieh C. Hematuria en pediatría. RevMedClin Condes. 2009;20(6):904–10.
5. Luque A, Reyes A, Canal MJ, Gómez-Campdera FJ, Morales MD. Causas y progresión de la insuficiencia renal crónica en la infancia. Nefrología. 1988;8(3):265–72.
6. R Core Team. R: A Language and Environment for Statistical Computing [Internet]. Vienna, Austria: R Foundation for Statistical Computing; 2014. AresesTrapote R, Sanahuja Ibáñez MJ, Navarro M. [Epidemiology of chronic kidney disease in Spanish pediatric population. REPIR II Project]. Nefrologia 2010 Jan [cited 2014 Dec 7];30(5):508–17.
7. Eddy A, Symons J. Nephrotic syndrome in childhood. Lancet 2003; 362:629-39.
8. Schlesinger E, Sultz H, Mosher W, Feldman J. The nephrotic syndrome: its incidence and implications for the community. Am J Dis Child 1968; 116:623-24.
9. Gofrey A, Barrat M. Responsive nephrotic syndrome. En: Barrat T, AdverE,HarmonW. Pediatricneprhology 7.Ed. Baltimore : Lipppincott Williams &Wilkins; 2007, p 731-47.
10. Ingulli E,Tejani A. Racial differences in the incidence and renal outcome of idiopathic focal segmental glomerulosclerosis in children. PediatrNephrol. 1991;5:393-7
11. Koch V, Gordillo G. Sindrome Nefrótico. En : Gordillo G, Exeni R, De La Cruz J Editores. NefrologiaPediatrica 3 Ed. Elsevier España; 2009 p 284-302
12. CattranDC,CoppoR.Cook HT, et al: The Oxfordclassification of IgAnephropathy :rationale,clinicopathological correlations, and classification. Kidney International .2009; 76 (5) : 534-45
13. Coppo R. Pediatric IgA nephropathy:clinical and therapeutic perspectives. Seminars in Nephrology. 2008 ; 1: 18-26.
14. Bolaños L,Castaño I. Características Clínicas e histopatológicas del sindrome nefrótico primario. ColombMéd 2005, 36; 1: 29-33
15. Gordillo PG,Garcia A, Mota HF. Síndrome nefrótico Ideopático. Rev. Mexicana Pediatria 1970, 39:121-126
16. Gulati S, Sharma AP, SharmaRK. Do current recommendations for kidney biopsy in nephrotic syndrome need modifications? PediatrNeprhol 2002; 17:404-08.
17. Mehls O, Rigden S, Ehrich JHH, Berthoux F, Jones EHP, Valderrabano F, on behalf of the EDTA-ERA Registry. Report on management of renal failure in Europe, XXV, 1994. The child-adult interface. Nephrol Dial Transplant 1996:11(Suppl 1):22-36