Congenital nephrotic syndrome debuting with disease of minimal changes, on the case of a case
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congenital nephrotic syndrome, hypoalbuminemia, minimal change disease, edema, proteinuria.

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Guerrero Varticovsky AV, Benitez Cardoza MC, Polo Castillo A, Bolaño Cervantes M. Congenital nephrotic syndrome debuting with disease of minimal changes, on the case of a case. Rev. Colomb. Nefrol. [Internet]. 2021 May 26 [cited 2024 Jul. 25];8(2):e455. Available from:


Nephrotic syndrome, is the most frequent primary glomerulopathy in Pediatrics, it is a pathology characterized by the presence of proteinuria, hypoalbuminemia, edema and hypercholesterolemia. This is a neonate with a history of prematurity and hospitalization at birth in whom, after multiple recurrent infections with torpid evolution during hospital stay and generalized edema, congenital nephrotic syndrome is suspected, obtaining positive paraclinics and renal biopsy that reports minimal change disease. Congenital nephrotic syndrome is a rare entity, however, it has high morbidity and mortality, it has various forms of clinical and histological presentation, and management is usually difficult with little response to corticosteroids. The presence of congenital nephrotic syndrome is unusual, however, it has high mortality and many subsequent sequelae, being chronic.
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1. Román Ortiz E. Síndrome nefrótico pediátrico. Protoc diagn ter pediatr. 2014
2. Consenso de tratamiento del síndrome nefrótico en la infancia Comité de Nefrología, Sociedad Argentina de Pediatría. 2014
3. Síndrome nefrótico idiopático: recomendaciones de la Rama de Nefrología de la Sociedad Chilena de Pediatría, Pilar Hevia. Revista chilena de pediatría 2015
4. Elena Cobos-Carrascosa, Ana Campos-Aguilera, Antonio Daza-Torres, Afectación multigénica en el síndrome nefrótico congénito sociedad española de Nefrologia 2014.
5. Beth a. vogt and tamar springel; The Kidney and Urinary Tract of the Neonate (libro)
6. Marta Azócar P, Síndrome nefrótico congénito por mutación del gen de la nefrina. Caso clínico. Rev Chil Pediatr 2011; 82 (5): 426-431
7. Pablo Bello Gutiérrez Síndrome nefrótico en el primer año de vida. An Pediatr Contin. 2014;12(1):17-24
8. Víctor Manuel Mora-Bautista, Síndrome nefrótico congénito. Reporte de caso y revisión del enfoque diagnóstico, Rev.Colomb.Nefrol. 2019;6(2):172-178, julio-diciembre de 2019.
9. MoodleyR, Naicker E, Bhimma R. Congenital nephrotic syndrome: A diagnostic andmanagement dilemma. South African J Child Heal. 2015;9(4):140.
10. Hannu Jalanko. Congenital nephrotic syndrome. Pediatric Nephrology volume 24, pages2121–2128(2009).
11. Bernward G. Hinkes. Nephrotic Syndrome in the First Year of Life: Two Thirds of Cases Are Caused by Mutations in 4 Genes (NPHS1, NPHS2, WT1, and LAMB2). Pediatrics volumen 119, april 2007.
12. Cheong HI. Genetic tests in children with steroid-resistant nephrotic syndrome. Kidney Res Clin Pract. 2020 Mar 31
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