Clinical approach and diagnosis of membranoproliferative glomerulonephritis, case report
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Nephrotic Syndrome, Glomerulonephritis, Membranoproliferative Glomerulonephritis, Proteinuria, Complement Activation, Acute Kidney Injury.

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Torres Serrano RE, Rosselli Sanmartín C, Olivares Algarín O, Olivares Algarín CR, Latorre Núñez Y, Moreno Lucero PA, Zambrano Amastha LC, Ardila Castillo W. Clinical approach and diagnosis of membranoproliferative glomerulonephritis, case report. Rev. Colomb. Nefrol. [Internet]. 2020 Oct. 20 [cited 2024 Jul. 15];7(2). Available from:


The membranophroliferative glomerulonephritis is a rare lesion that covers a group of pathologies that share a histologic pattern, and can generate from diverse pathogenic mechanisms. Based on the findings of the kidney biopsy, starts a process to search the etiology of the lesion. The initial kidney damage occurs due to the deposit of immunoglobulins, complement elements or both in the mesangium and in the capillary endothelium, generating sub endothelial, sub epithelial, and/or glomerular basal membrane deposits, frequently adopting glomerulus a lobed aspect. We present a case of a man 48 years old admitted in the emergency of the San Jose Hospital in Bogotá, without relevant pathological background that debuts with proteinuria in severe nephrotic range (62 grams in 24 hours), nitrogenous elevation and biopsy report with membranophroliferative glomerulonephritis, we describe de clinical and diagnostic approach of this entity.
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