Abstract
Background: Cost analysis studies of chronic kidney disease (CKD) have primarily focused on direct costs. Peritoneal dialysis (PD) is more cost-effective than hemodialysis (HD); however, the time spent by patients and caregivers on treatment is usually not considered.
Objective: To estimate the indirect costs and out-of-pocket expenses associated with chronic kidney disease on peritoneal dialysis compared to hemodialysis in Bogotá, Colombia.
Methods: A cost analysis study was conducted. Out-of-pocket expenses were estimated by the weighted average of monthly events per reported dialysis-related expenditure. Indirect costs were estimated on a monthly basis, taking into account transportation time, dialysis procedure time, and perceived patient and caregiver disability. Univariate and multivariate analyses were performed to compare costs between peritoneal dialysis and hemodialysis. Estimated values in Colombia were shown per minimum wage (MW) in 2023. A significance level of p < 0.05 was considered.
Results: We included 132 patients, 40 on PD and 92 on HD, with a median age of 61 years (IQR: 43.7-72.25), of which 43.9% were female. Patients on PD reported being more occupationally active than those on HD (p = 0.028). Catastrophic expenditure was reported by 28.2% of the cohort. The median out-of-pocket expense was 0.41 MW, USD 112.3 (IQR 55.2-200.1), per month, with no differences between therapies (p = 0.17). Indirect costs were higher among patients receiving HD, at 1.64 MW and USD 447.2 (IQR 201.3-766.2), compared to those receiving PD, at 0.56 MW and USD 153.3 (IQR 46.8-511.1) (adjusted p = 0.0002).
Conclusion: Catastrophic expenditure was reported by 28.2% of the cohort. Indirect costs were higher in HD compared to PD. A larger sample size is required to identify differences in out-of-pocket expenses and between different modalities of PD.
References
Cockwell P, Fisher L-A. The global burden of chronic kidney disease. Lancet. 2020;395(10225):662–664. https://doi.org/10.1016/S0140-6736(19)32977-0
Cuenta de alto costo de Colombia. Situación de la enfermedad renal crónica, la hipertensión arterial y diabetes mellitus en Colombia 2019 [Internet]. Cuenta de alto costo de Colombia;2020 [cited 2021 Oct 11]. https://cuentadealtocosto.org/site/erc/
Sarmiento-Bejarano H, Ramírez-Ramírez C, Carrasquilla-Sotomayor M, Alvis-Zakzuk NJ, Alvis-Guzmán N. Economic burden of chonic kidney disease in Colombia, 2015-2016. Salud Uninorte. 2019;35(1):84–100. https://doi.org/10.14482/sun.35.1.616.6
Kaplan JM, Niu J, Ho V, Winkelmayer WC, Erickson KF. A Comparison of US medicare expenditures for hemodialysis and peritoneal dialysis. J Am Soc Nephrol. 2022;33(11):2059–2070. https://doi.org/10.1681/ASN.2022020221
Rosselli D, DeAntonio R, Calderón C. Análisis económico de diálisis peritoneal comparada con hemodiálisis en pacientes con enfermedad renal crónica, diabética o hipertensiva. MedUNAB. 2008;11(3):201–205.
Tang C-H, Chen H-H, Wu M-J, Hsu B-G, Tsai J-C, Kuo C-C, et al. Out-of-pocket costs and productivity losses in haemodialysis and peritoneal dialysis from a patient interview survey in Taiwan. BMJ Open. 2019;9(3):e023062. https://doi.org/10.1136/bmjopen-2018-023062
Walker RC, Howard K, Tong A, Palmer SC, Marshall MR, Morton RL. The economic considerations of patients and caregivers in choice of dialysis modality. Hemodial Int. 2016;20(4):634–642. https://doi.org/10.1111/hdi.12424
Krol M, Brouwer W. How to estimate productivity costs in economic evaluations. Pharmacoeconomics. 2014;32(4):335–344. https://doi.org/10.1007/s40273-014-0132-3
Shahrook S, Mori R, Dovey SM, Koyanagi A, Shibuya K. Changes in out?of?pocket payments on utilisation of health care services. Cochrane Database Syst Rev. 2019;2019. https://doi.org/10.1002/14651858.CD003029.pub4
Wainstein M, Bello AK, Jha V, Harris DCH, Levin A, Gonzalez-Bedat MC, et al. International society of nephrology global kidney health atlas: structures, organization, and services for the management of kidney failure in Latin America. Kidney Int Suppl. 2021;11(2):e35–46. https://doi.org/10.1016/j.kisu.2021.01.005
Calice-Silva V, Neyra JA, Ferreiro Fuentes A, Singer Wallbach Massai KK, Arruebo S, Bello AK, et al. Capacity for the management of kidney failure in the International Society of Nephrology Latin America region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA). Kidney Int Suppl. 2024;13(1):43–56. https://doi.org/10.1016/j.kisu.2024.01.001
Ulasi II, Awobusuyi O, Nayak S, Ramachandran R, Musso CG, Depine SA, et al. Chronic kidney disease burden in low-resource settings: Regional perspectives. Semin Nephrol. 2022;42(5):151336. https://doi.org/10.1016/j.semnephrol.2023.151336
Harris PA, Taylor R, Minor BL, Elliott V, Fernandez M, O’Neal L, et al. The REDCap consortium: Building an international community of software platform partners. J Biomed Inform. 2019;95:103208. https://doi.org/10.1016/j.jbi.2019.103208
CEIC. Gasoline Retail Price [Internet]. CEIC;2023 [cited 2023 Jun 25]. https://www.ceicdata.com/en/colombia/gasoline-retail-price
Sanabria M, Rodríguez MS, Sánchez KR, Astudillo K, Camargo D, Bunch A. Frecuencia y costos de hospitalización en una población de pacientes en diálisis en Colombia. Rev Fac Med. 2012;60(4):293–301.
Valsa Jose J, Susan George J, Joseph R, Arun Thomas ET, Philip John G. Out-of-pocket expenditures, catastrophic household finances, and quality of life among hemodialysis patients in Kerala, India. Hemodial Int. 2022;26(4):569–574. https://doi.org/10.1111/hdi.13037
Wong CKH, Chen J, Fung SKS, Mok MMY, Cheng YL, Kong I, et al. Direct and indirect costs of end-stage renal disease patients in the first and second years after initiation of nocturnal home haemodialysis, hospital haemodialysis and peritoneal dialysis. Nephrol Dial Transplant. 2019;34(9):1565–1576. https://doi.org/10.1093/ndt/gfy395
OECDiLibrary. Health at a Glance 2021: OECD Indicators [Internet]. OECDiLibrary;2021 [cited 2023 Jun 2]. https://www.oecd.org/en/publications/2021/11/health-at-a-glance-2021_cc38aa56.html
de Vries EF, Los J, de Wit GA, Hakkaart - van Roijen L. Patient, family and productivity costs of end-stage renal disease in the Netherlands; exposing non-healthcare related costs. BMC Nephrol. 2021;22(1):341. https://doi.org/10.1186/s12882-021-02548-y
Orias M, Rosa Diez GJ. Global dialysis perspective: Argentina. Kidney360. 2020;1(7):676–679. https://doi.org/10.34067/KID.0001222019
Santacruz Mancheno J, Santacruz AC. Global Dialysis Perspectives: Ecuador. Kidney360. 2022;3(12). https://doi.org/10.34067/KID.0003762022
Bitran R. Explicit health guarantees for Chileans: The AUGE benefits package. UNICO Studies Series. 2013;(21). https://doi.org/10.1596/13281
Saldarriaga EM, Bravo-Zúñiga J, Hurtado-Roca Y, Suarez V. Cost-effectiveness analysis of a strategy to delay progression to dialysis and death among chronic kidney disease patients in Lima, Peru. Cost Eff Resour Alloc. 2021;19(1):70. https://doi.org/10.1186/s12962-021-00317-0
Arellan-Bravo L, Benito-Condor B, Gutiérrez-Aguado A. Direct cost analysis of renal replacement therapy in a Peruvian hospital. Acta Medica Peru. 2024;41(2):74–82. https://doi.org/10.35663/amp.2024.412.2845
van der Tol A, Lameire N, Morton RL, Van Biesen W, Vanholder R. An international analysis of dialysis services reimbursement. Clin J Am Soc Nephrol. 2019;14(1):84–93. https://doi.org/10.2215/CJN.08150718
Moalosi K, Sibanda M, Kurdi A, Godman B, Matlala M. Estimated indirect costs of haemodialysis versus peritoneal dialysis from a patients’ perspective at an Academic Hospital in Pretoria, South Africa. BMC Health Serv Res. 2023;23(1):1119. https://doi.org/10.1186/s12913-023-10109-2
Julián-Mauro JC, Cuervo J, Rebollo P, Callejo D. Situación laboral y costes indirectos en pacientes con insuficiencia renal: Diferencias entre distintas modalidades de tratamiento renal sustitutivo. Nefrologia. 2013;33(3):333–341. https://dx.doi.org/10.3265/Nefrologia.pre2012.Dec.11767
Hirth RA, Greer SL, Albert JM, Young EW, Piette JD. Out-of-pocket spending and medication adherence among dialysis patients in twelve countries. Health Aff (Millwood). 2008;27(1):89–102. https://doi.org/10.1377/hlthaff.27.1.89
Tang C-H, Wu Y-T, Huang S-Y, Chen H-H, Wu M-J, Hsu B-G, et al. Economic costs of automated and continuous ambulatory peritoneal dialysis in Taiwan: a combined survey and retrospective cohort analysis. BMJ Open. 2017;7(3):e015067. https://doi.org/10.1136/bmjopen-2016-015067

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

