Therapeutic plasma exchange in patients with pauciimmune vasculitis: Hospital Universitario San Ignacio experience; Bogotá, Colombia
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Keywords

Apheresis, plasmapheresis, therapeutic plasma exchange, vasculitis, ANCA.

How to Cite

1.
Córdoba JP, Contreras K, Hurtado M, Pinto J, Rodriguez MP, Larrarte C. Therapeutic plasma exchange in patients with pauciimmune vasculitis: Hospital Universitario San Ignacio experience; Bogotá, Colombia. Rev. Colomb. Nefrol. [Internet]. 2014 Jan. 2 [cited 2022 May 18];1(1):3-9. Available from: https://revistanefrologia.org/index.php/rcn/article/view/167

Abstract

Introduction: The vasculitis ANCAS positive, are a group of diseases with different clinical manifestations. Therapeutic plasma exchange has become an excellent tool for the treatment of these patients in specific conditions.

Objective: Describe the demographic and clinical characteristics of patients and the final outcomes in patients with positive ANCAS vasculitis that required therapeutic plasma exchange (TPE).

Materials and methods: All patients under 18 years old with positive ANCAS vascultiis that required TPE where included during the period of May 2010 and December 2013.

Results: 13 patients where treated, with a total of 73 TPE sessions. The average age was 52,3 years (Range 17 to 70). The principal diagnosis for interventions was rapidly progressive glomerulonephritis (RPGN) plus alveolar hemorrhage (63%). The average number of sessions per patient was 5,6 (range 1 a 10) with an average of plasma volume exchange per session of 1,26 (range 0.72 a 1,56). Of the 13 patients, 11 (84,6%) required renal replacement therapy (RRT) during hospitalization. At discharge, 36.3% recover the renal function, 27% continue on RRT and 36,3% died. There was at least one complication in 6,8% of all sessions.

Conclusions: TPE is an excellent tool to treat patients with positive ANCAS vasculitis that present with RPGN, high levels of serum creatinine or dialysis need, or alveolar hemorrhage. This is a safe procedure with comparable results according to International literature.

https://doi.org/10.22265/acnef.1.1.167
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