Nephritis Tubule Interstitial for Leflunomide
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Nefritis tubulo intersticial por leflunomide (Español)


Tubule interstitial

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Hurtado M, Barbosa Silva OR, Santacruz F. Nephritis Tubule Interstitial for Leflunomide. Rev. Colomb. Nefrol. [Internet]. 2016 Nov. 18 [cited 2024 Feb. 26];3(2):132-6. Available from:


The link between renal Tubule Interstitial Nephritis and the use of Leflunomide has not been described in the literature yet, this drug is not recognized as a nephrotoxic; therefore tracking renal function is not usually performed. We report the case of a patient admitted to the University Hospital of Clinic San Rafael by non-specific clinical symptoms and rapid deterioration of renal function. After ruling out the usual causes, we performed a renal biopsy, documenting the presence of severe tubule interstitial nephritis. By the time the use of Leflunomide was the only unusual precedent. After we suspended the treatment, the patient showed full recovery of the renal function. It is our intention to describe this case to highlight the connection between renal Tubule Interstitial Nephritis and the use of Leflunomide in order to promote keeping track of similar cases.
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