Acute post-infectious glomerulonephritis as a risk for developing chronic kidney failure in a pediatric cohort at a reference hospital in Paraguay
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Keywords

glomerulonephritis
proteinuria
chronic kidney disease
pediatrics
, nephritic syndrome.

How to Cite

1.
Troche A, Samudio M. Acute post-infectious glomerulonephritis as a risk for developing chronic kidney failure in a pediatric cohort at a reference hospital in Paraguay. Rev. Colomb. Nefrol. [Internet]. 2023 Jan. 12 [cited 2023 Jan. 27];10(1). Available from: https://revistanefrologia.org/index.php/rcn/article/view/632

Abstract

Background: Acute post-infectious glomerulonephritis (PIGN) represents a risk for the development of long-term renal failure.

Purpose: To describe the incidence of proteinuria in patients with a history of PIGN in a pediatric cohort at a referral hospital in Paraguay.

Methodology: a total of 121 patients with nephritic syndrome with decreased C3 and normalization at 3 months, although streptococcal aetiology has not been proven were included. Patients with with previous kidney disease, with secondary nephritic syndrome and with less than 6 months of follow-up were excluded. Sociodemographic characteristics, previous infection, creatinine clearance, days of arterial hypertension and hospitalization were analyzed, in addition to their relationship with the persistence of proteinuria at 6 months and more of follow-up.

Results: Of the 121 patients between 2 and 16 years of age included, 75 patients had a medical follow-up between 6 and 48 months, 43 (57.3%) of them developed persistent proteinuria, which was associated with lower creatinine clearance (p = 0.03; 67.74 ± 25.69 mL/min/1.73 m2 BM vs 80.22 ± 2.98 mL/min/1.73 m2 BM), higher average number of cohabitants (6.3 ±2.8 vs 5.3±2.3; p= 0.027) and higher average number of children (4.3±2.7 vs 3.6±2.3; p= 0.048). No association was found with other characteristics.

Conclusions: the incidence of proteinuria in this series was associated with lower creatinine clearance and a higher frequency of social determinants in health.

https://doi.org/10.22265/acnef.10.1.632
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