Impact of predialysis therapy on kidney transplant outcomes
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Peritoneal dialysis, hemodialysis, renal transplantation, survival, graft rejection

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Serna Higuita LM, Nieto-Ríos JF, García Prada CA, Aristizabal Alzate A, Zuluaga Valencia GA. Impact of predialysis therapy on kidney transplant outcomes. Rev. Colomb. Nefrol. [Internet]. 2021 Feb. 18 [cited 2024 Jul. 16];8(2):e487. Available from:


Introduction: Kidney transplantation is the standard treatment option for patients with end-stage chronic kidney disease. However, early kidney transplantation is not always possible, and many patients require renal replacement therapy. This study aims to evaluate the short and long-term outcomes after kidney transplantation in patients undergoing dialysis therapy before transplantation.

Methods: A retrospective cohort of renal transplant patients older than 18 years of age were evaluated during the years 2005-2018. A descriptive analysis was performed. A proportional Cox-Hazard model was used to evaluate the relationship between patient and transplant survival and pre-transplant dialysis.  An analysis of variance was used to compare the glomerular filtration rate during the first two years after transplantation.

Results: Between 2005-2018, 925 kidney transplants were performed, of which 289 required peritoneal dialysis, 439 haemodialysis and 197 did not require dialysis. Patient and transplant survival rates at 6, 12, 24, 48, 60 months after kidney transplantation were 97.5%, 96.7%, 96.0%, 93.7%, 92.3%, 94.5%, 92.9%, 90.5%, 84.8%, 81.1%. No statistically significant difference was found between peritoneal dialysis patients and hemodialysis patients (p=0.402, p=0.180). Acute rejection occurred in 8.1% of patients in the first year after transplantation and in 13.2% during the entire follow-up. Glomerular filtration rate values were similar in patients with and those without pre-transplant dialysis

Conclusions: There were no significant statistical differences in short and long-term outcomes among patients undergoing pre-transplant dialysis vs. no.
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