Characterization of subclinical chronic kidney disease in Chile
PDF (Español)
XML-JATS (Español)

Keywords

kidney diseases; renal insufficiency, chronic kidney disease, asymptomatic diseases, early diagnosis, glomerular filtration rate, albuminuria

How to Cite

1.
Castillo AA, Castillo Montes M. Characterization of subclinical chronic kidney disease in Chile. Rev. Colomb. Nefrol. [Internet]. 2022 Sep. 2 [cited 2024 Mar. 29];9(2). Available from: https://revistanefrologia.org/index.php/rcn/article/view/585

Abstract

Introduction: subclinical chronic kidney disease (CKDs), performing screening in at-risk populations, is poorly characterized in Chile. Its knowledge would contribute to better management and early treatment, mitigating its consequences. Objective: to describe the epidemiological and clinical characteristics of the population with CKDs in Chile. Materials and methods: cross-sectional descriptive study in a population of 1,032 subjects from three regions of Chile; Coquimbo (n=902), Metropolitana (n=70) and De Los Ríos (n=60), from cardiovascular programs, other Primary Care programs and direct relatives of dialysis patients. Informed consent, survey, physical examination (blood pressure, weight and height) and laboratory tests (creatinine and albumin/creatinine urinary ratio) were performed. CKD was defined by KDOQI-2012 guideline and Glomerular Filtration Rate according to MDRD formula. Albuminuria by relation albumin/creatinine of first urination (mg/g). eVFG <60 ml/min and/or Albuminuria ? 30 mg/g, defined CKDs. Frequencies and comparisons were determined (chi-square, t student and ANOVA), with a significance level of p<0.05. Results: 205 subjects (19.9%) presented CKDs, being significantly more frequent in ?65 years (35.7%), who achieved elementary school studies (26.6%), domestic service workers (44%), retired workers (40%), having a family member on dialysis (24.6%) and insulin-requesting diabetics (70.6%). In the ?65 year-old group, there was a significantly lower frequency of CKDs in those who performed physical activity, compared to sedentary (48.8%). The higher the intensity of hypertension and pulse pressure (PP), the higher the frequency of CKDs. Conclusions: These data provide useful epidemiological information for the programming of better detection strategies for CKDs in Chile

https://doi.org/10.22265/acnef.9.2.585
PDF (Español)
XML-JATS (Español)

References

Ene-Iordache B, Perico N, Bikbov B, Carminati S, Remuzzi A, Perna A, et al. Chronic kidney disease and cardiovascular risk in six regions of the world (ISN-KDDC): A cross-sectional study. Lancet Glob Health. 2016;4(5):e307-19. https://doi.org/10.1016/S2214-109X(16)00071-1

Grams M, McDonald S. Epidemiology of chronic kidney disease and dialysis. En: Feehally J, Floege J, Tonelli M, Johnson R, editores. Comprehensive Clinical Nephrology. 6 ed. Elsevier; 2019. p 903-12.

Gansevoort R, Correa-Rotter R, Hemmelgarn B, Jafar T, Lambers-Heerspink H, Mann J, et al. Chronic kidney disease and cardiovascular risk: Epidemiology, mechanisms, and prevention. Lancet. 2013;382(9889):339-52. https://doi.org/10.1016/S0140-6736(13)60595-4

Keith D, Nichols G, Gullion C, Betz-Brown J, Smith D. longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization. Arch Intern Med. 2004;164(6):659-63. https://doi.org/10.1001/archinte.164.6.659

Webster A, Nagler E, Morton R, Masson P. Chronic Kidney Disease. Lancet. 2017;389(10075):1238-52. https://doi.org/10.1016/S0140-6736(16)32064-5

Stevens L, Coresh J, Greene T, Levey A. Assessing Kidney Function - Measured and Estimated Glomerular Filtration Rate. N Engl J Med. 2006;354(23):2473-83. https://doi.org/10.1056/NEJMra054415

Ministerio de Salud de Chile [sitio web]. Santiago de Chile [citado 2021 oct. 7]. Guía Clínica Insuficiencia Renal Crónica Terminal. 2005; [37 p]. Disponible en: http://diprece.minsal.cl/wrdprss_minsal/wp-content/uploads/2014/12/Insuficiencia-Renal-cronica-terminal.pdf

Ministerio de Salud de Chile. Guía Clínica Prevención de Enfermedad Renal Crónica. Serie Guías cínicas Minsal. 2010. 35 p.

Ministerio de Salud de Chile [sitio web]. Santiago de Chile [citado 2021 oct. 7]. Guías de Práctica Clínicas Ges Prevención Secundaria de la Enfermedad Renal Crónica en Chile. 2017; [54 p]. Disponible en: https://diprece.minsal.cl/wrdprss_minsal/wp-content/uploads/2018/01/2017.10.24_ENFERMEDAD-RENAL-CRONICA.pdf

Sociedad Chilena de Nefrología [sitio web]. Valparaíso, Chile; 2019 [citado 2021 oct. 7]. Poblete H. XXXVII Cuenta De Hemodiálisis Crónica (Hdc) en Chile (al 31 de agosto de 2019). [117 p]. Disponible en: https://www.nefro.cl/web/biblio/registro/37.pdf

Cámara de Diputados de Chile [sitio web]. FONASA, Licitación de diálisis. Presentación Comisión Salud Cámara Diputados. 2017. Valparaíso [citado 2021 oct. 7]. Disponible en: https://www.camara.cl/pdf.aspx?prmID=108646&prmTIPO=DOCUMENTOCOMISION.

Cueto-Manzano A, Martínez-Ramírez H, Cortés-Sanabria L. Comparison of primary health-care models in the management of chronic kidney disease. Kidney Int Suppl. 2013;3(2):210-4. https://doi.org/10.1038/kisup.2013.16

Wong M, Perkovic V, Chalmers J, Woodward M, Li Q, Cooper M, et al. Long-term benefits of intensive glucose control for preventing end-stage kidney disease: ADVANCE-ON. Diabetes Care. 2016;39(5):694-700. https://doi.org/10.2337/dc15-2322

Bello A, Alrukhaimi M, Ashuntantang G, Bellorin-Font E, Benghanem-Gharbi M, Braam B, et al. Global overview of health systems oversight and financing for kidney care. Kidney Int Suppl. 2018;8(2):27-9. https://doi.org/10.1016/j.kisu.2017.10.008

Tonelli M, Dickinson J. Early Detection of CKD: Implications for Low-Income, Middle-Income, and High-Income Countries. JASN. 2020;31:1931-40. https://doi.org/10.1681/ASN.2020030277

Romagnani P, Remuzzi G, Glassock R, Levin A, Jager K, Tonelli M, et al. Chronic kidney disease. Nat Rev Dis Primers. 2017;3(17088):1-24. https://doi.org/10.1038/nrdp.2017.88

Villaroel P, Parra X, Ardiles L. Prevalencia y clasificación de enfermedad renal crónica en pacientes con diabetes mellitus tipo 2 en el centro comunitario de salud familiar Pantanosa, Frutillar. Rev Med Chil. 2012;287-94. http://dx.doi.org/10.4067/S0034-98872012000300002

Zúñiga C, Müller H, Flores M. Prevalencia de enfermedad renal crónica en centros urbanos de atención primaria. Rev Med Chil. 2011;139(9):1176-84. http://dx.doi.org/10.4067/S0034-98872011000900010

Levey A, Coresh J. Chronic kidney disease. Lancet. 2012;379(9811):165-80. https://doi.org/10.1016/S0140-6736(11)60178-5

Jha V, García-García G, Iseki K, Li Z, Naicker S, Plattner B, et al. Chronic kidney disease: Global dimension and perspectives. Lancet. 2013;382(9888):260-72. https://doi.org/10.1016/S0140-6736(13)60687-X

Walbaum M, Scholes S, Pizzo E, Paccot M, Mindell J. Chronic kidney disease in adults aged 18 years and older in Chile: findings from the cross-sectional Chilean National Health Surveys 2009-2010 and 2016-2017. BMJ Open. 2020;10:e037720. https://doi.org/10.1136/bmjopen-2020-037720

KDIGO Group. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int Suppl. 2013;3(1):1-150. https://doi.org/10.1038/kisup.2012.64

Ministerio de Salud de Chile. Santiago de Chile; Departamento de Epidemiología. I Encuesta de Salud Chile; 2003.

Ministerio de Salud de Chile [sitio web]. Santiago de Chile [citado 2021 oct. 7]. Encuesta Nacional de Salud ENS Chile 2009-2010; 2010. Disponible en: http://www.minsal.cl/portal/url/item/bcb03d7bc28b64dfe040010165012d23.pdf

Komenda P, Ferguson T, Macdonald K, Rigatto C, Koolage C, Sood M, et al. Cost-effectiveness of primary screening for CKD: A systematic review. Am J Kidney Dis. 2014;63(5):789-97. https://doi.org/10.1053/j.ajkd.2013.12.012

Ministerio del Trabajo y Previsión Social. [sitio web]. Primera Encuesta Nacional de Empleo, Trabajo, Salud y Calidad de Vida de los Trabajadores y Trabajadoras en Chile; 2011. Santiago [citado 2021 oct. 7]. Disponible en: https://www.dt.gob.cl/portal/1629/articles-99630_recurso_1.pdf

Skrunes R, Svarstad E, Reisæter A, Vikse B. Familial clustering of ESRD in the norwegian population. Clin J Am Soc Nephrol. 2014;9(10):1692-700. https://doi.org/10.2215/CJN.01680214

Freedman B, Robinson T. Risk factors: familial aggregation of ESRD in Europeans-is it in the genes? Nat Rev Nephrol. 2014;10(12):677-8. https://doi.org/10.1038/nrneph.2014.181

Nagasawa Y, Yamamoto R, Rakugi H, Isaka Y. Cigarette smoking and chronic kidney diseases. Hypertension Research. 2012;35(3):261-65. https://doi.org/10.1038/hr.2011.205

Murphy D, McCulloch C, Lin F, Banerjee T, Bragg-Gresham J, Eberhardt M, et al. Trends in prevalence of chronic kidney disease in the United States. Ann Intern Med. 2016;165(7):473-81. https://doi.org/10.7326/M16-0273

Umanath K, Lewis J. Update on Diabetic Nephropathy: Core Curriculum 2018. Am J Kidney Dis. 2018;71(6):884-95. https://doi.org/10.1053/j.ajkd.2017.10.026

Navarro G, Ardiles L. Obesidad y enfermedad renal crónica: Una peligrosa asociación. Rev Med Chil. 2015;143(1):77-84. http://dx.doi.org/10.4067/S0034-98872015000100010

Kovesdy C, Furth S, Zoccali C. Obesity and kidney disease: Hidden consequences of the epidemic. Nefrología. 2017;37(4):360-9. https://doi.org/10.1016/j.nefro.2017.02.005

Stenvinkel P, Zoccali C, Ikizler T. Obesity in CKD-What Should Nephrologists Know? J Am Soc Nephrol. 2013;24(11):1727-36. https://doi.org/10.1681/ASN.2013040330

Stevens L, Schmid C, Greene T, Zhang Y, Beck G, Froissart M, et al. Comparative performance of the CKD Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) Study equations for estimating GFR levels above 60 mL/min/1.73 m2. Am J Kidney Dis. 2010;56(3):486-95. https://doi.org/10.1053/j.ajkd.2010.03.026

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Dimensions


PlumX


Downloads

Download data is not yet available.