Palabras clave
inmunosupresión
traspante renal
inhibidores mTOR
herpes 8
Cómo citar
Resumen
Introducción: el sarcoma de Kaposi en pacientes de postrasplante renal es poco frecuente y está asociado usualmente a infección por herpes 8 y a dosis altas de inmunosupresión.
Objetivo: descripción reporte de caso de Sarcoma de Kaposi en orofaringe en paciente postrasplante renal manejo con inhibidor de señal de coestimulación e inhibidor mTOR.
Presentación del caso: en este artículo se describe el caso de una paciente, con antecedente de trasplante renal, con diagnóstico de sarcoma de Kaposi en una localización muy poco frecuente: a nivel orofaríngeo. Se realiza una revisión de los factores de riesgo, patogenia y un acercamiento en el manejo. De igual manera, se realiza un seguimiento y manejo con inhibidor de señal de coestimulación (belatacept) e inhibidor de mTOR.
Discusión y conclusión: el sarcoma de Kaposi es una de las neoplasias postrasplante con mayor incidencia comparativamente con la población no trasplantada, donde el papel de la reactivación de la infección viral, más el papel de la inmunosupresión, son puntos fundamentales en la génesis de la neoplasia. La determinación del estatus serológico IgG para HHV8 podría ser una estrategia de determinación del riesgo en el pretrasplante.
Citas
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