High altitude nephropathy, a new nephrologic entity
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Sea Level
Glomerular Filtration Rate

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Vizcarra Vizcarra CA, Flores Vera K. High altitude nephropathy, a new nephrologic entity. Rev. Colomb. Nefrol. [Internet]. 2024 Jun. 21 [cited 2024 Jul. 25];11(2). Available from: https://revistanefrologia.org/index.php/rcn/article/view/742


Millions of people are exposed to high altitude (GA), acutely (travelers), intermittently (workers who go to high altitude and then return to sea level) or chronically (inhabitants of high altitude cities), resulting in various physiological alterations.

During acute exposure to GA, changes are observed in the respiratory, cardiovascular and hematological systems, which occur in order to improve tissue oxygenation. On the other hand, the kidney is also affected by hypobaric hypoxia, leading to increased erythropoietin and changes in glomerular filtration rate (GFR), renal blood flow and urinary excretion of protein, bicarbonate, hydrogen, sodium and water.

Inhabitants of high altitude cities present various alterations that cause renal damage and that are usually more evident at higher altitudes. Therefore, renal syndrome at high altitude (RAS) has been recognized as an entity that occurs in residents of cities located above 2500 meters above sea level (m asl), who usually develop proteinuria, polycythemia, arterial hypertension and hyperuricemia, which leads to deterioration of renal function.

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Palubiski LM, O’Halloran KD, O’Neill J. Renal physiological adaptation to high altitude: a systematic review. Front Physiol. 2020;11:756. https://doi.org/10.3389/fphys.2020.00756

Arestegui AH, Fuquay R, Sirota J, Swenson ER, Schoene RB, Jefferson JA, et al. High altitude renal syndrome (HARS). JASN. 2011;22(11):1963-8. https://doi.org/10.1681/ASN.2010121316

Chen W, Liu Q, Wang H, Chen W, Johnson RJ, Dong X, et al. Prevalence and risk factors of chronic kidney disease: a population study in the Tibetan population. Nephrol Dial Transplant. 2011;26(5):1592-9. https://doi.org/10.1093/ndt/gfq608

Hurtado-Arestegui A, Plata-Cornejo R, Cornejo A, Mas G, Carbajal L, Sharma S, et al. Higher prevalence of unrecognized kidney disease at high altitude. J Nephrol. 2018;31(2):263-9. https://doi.org/10.1007/s40620-017-0456-0

Gilbert-Kawai E, Martin D, Grocott M, Levett D. High altitude-related hypertensive crisis and acute kidney injury in an asymptomatic healthy individual. Extreme Physiol Med. 2016;5:10. https://doi.org/10.1186/s13728-016-0051-3

Yin Q, Yang Y, He T, Lai C, Liang Y, Jiang W, et al. A case of focal segmental glomerulosclerosis syndrome secondary to high-altitude polycythemia. Ren Fail. 2014;36(1):108-10. https://doi.org/10.3109/0886022X.2013.832857

Vizcarra-Vizcarra CA, Chávez-Velázquez E, Asato-Higa C, Hurtado-Aréstegui A. Treatment of focal and segmental glomerulosclerosis secondary to high altitude polycythemia with acetazolamide. High Alt Med Biol. 2022;23(3):286-90. https://doi.org/10.1089/ham.2021.0158

Vizcarra-Vizcarra C, Alcos-Mamani A, Asato-Higa C. ¿Cuándo realizar biopsia renal en un paciente diabético?. A propósito de un caso en una ciudad de altura. An Fac med. 2023;84(1):105-109. http://dx.doi.org/10.15381/anales.v84i1.23681

Rehman Arshad A, Islam F, Qayyum M. Renal vein thrombosis at high altitude. Pak Armed Forces Med J. 2021;71(supl. 1):S283-85. https://doi.org/10.51253/pafmj.v71iSuppl-1.2444

Vizcarra-Vizcarra CA, Alcos-Mamani AL. High altitude pulmonary edema in a chronic kidney disease patient-is peritoneal dialysis a risk factor? High Alt Med Biol. 2022;23(1):96-9. https://doi.org/10.1089/ham.2021.0136

Vizcarra Vizcarra CA. Policitemia en pacientes con enfermedad renal crónica en hemodiálisis. Rev Cuba Med Mil. 2022;51(2):02201852. https://revmedmilitar.sld.cu/index.php/mil/article/view/1852/1327

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