Relationship between altered parathyroid hormone and bone fractures in hemodialysis patients
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Keywords

Bone Fractures
Parathyroid Hormone
Dialysis
Hemodialysis
Chronic Kidney Disease
Risk Factor

How to Cite

1.
Guzman-Ventura W, Villacorta Díaz M. Relationship between altered parathyroid hormone and bone fractures in hemodialysis patients. Rev. Colomb. Nefrol. [Internet]. 2023 Sep. 28 [cited 2024 Feb. 26];10(3). Available from: https://revistanefrologia.org/index.php/rcn/article/view/700

Abstract

Background: Bone fractures in patients on dialysis are frequent and impose a high burden of disability and multimorbidity. They have been linked to mineral-bone disorders but its association with parathyroid hormone remains controversial.

Purpose: To determine the relationship between altered parathyroid hormone (PTH) and bone fractures in hemodialysis patients.

Metthodology: A cross-sectional, analytical study was conducted in 250 hemodialysis patients attending Hospital Víctor Lazarte Echegaray from 2015 to 2020. Patients were classified according to whether their PTH was altered (PTH <150 or >300 pg/ml) and whether bone fractures were present. The association between altered PTH and the presence of bone fractures was determined using bivariate and multivariate analysis; the results are presented as odds ratio (OR) considering a significant p-value if <0.05.

Results: 250 patients were evaluated in which 69 (27.6%) had altered PTH, 181 (72.4%) had normal PTH; likewise, 42 (16.8%) had bone fractures and 208 (83.2%) had no bone fractures. Of the 42 patients with bone fractures, 22 (52.4%) had altered PTH and 20 (47.6%) had normal PTH; of the 208 patients without bone fractures, 47 (22.6%) had altered PTH and 161 (77.4%) had normal PTH (p=0.001). Altered PTH was associated with the presence of bone fractures with OR: 3.77 (95% CI: 1.90-7.49) in the bivariate analysis and with OR: 2.85 (95% CI: 1.19-6.82) in the multivariate analysis. The covariates that were associated with the presence of bone fractures were being over 60 years (OR: 2.74, 95% CI: 1.12-6.69) and having been on hemodialysis for more than 5 years (OR: 6.72, 95% CI: 2.98-15.13).

Conclusions: Altered parathyroid hormone is related with bone fractures in hemodialysis patients.

https://doi.org/10.22265/acnef.10.3.700
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