COVID-19 in kidney transplant recipients: A experience in Colombia
PDF (Español)
XML-JATS (Español)



How to Cite

Duran CE, Estacio M, Mesa L, Schweinberg J, Posada JG, Espinosa D, Manzi E, Lozano F, Castro A. COVID-19 in kidney transplant recipients: A experience in Colombia. Rev. Colomb. Nefrol. [Internet]. 2022 Dec. 3 [cited 2024 Jul. 18];9(3). Available from:


Background: Patients with kidney transplants seem to be at particularly high risk for severe COVID19 disease due to their impaired immune responses and comorbidities.

Purpose: This study aims to describe kidney transplant patients’ clinical characteristics and outcomes with SARSCOV-2 infection in a fourth-level hospital in Cali, Colombia.

Methodology: We performed an observational study of kidney transplant recipients with SARS-CoV2 infection admitted at Fundación Valle del Lili from June to December 2020. To be eligible for this study, patients have symptoms compatible, a positive RT-PCR and inpatient management. Asymptomatic patients were excluded.

Results: We enrolled a total of 50 patients. 64% were male, and the median age was 53.5 years (range 46-60). The comorbidities were 36 (70%) hypertension, 16 (32%) diabetes mellitus, 5 (10%) obesity. The most common immunosuppressive regimen was tacrolimus, mycophenolate and prednisone. The median time from symptoms onset to the positive RT-PCR was 7 days. The most common initial symptom was fever (64%), and fatigue (58%), cough (44%) and dyspnea (36%). Baseline levels of CRP was 6.43 mg/dL (3.25-11.22). The median lymphocyte count was 785 mm3/uL (550-1230). Baseline D-Dimer was 0.767 ug/ml (0.484-1153.5), ferritin median level was 1011ng/ml (670-2145). Six of the patients died (12%), 4/6 were by sepsis-related multi-organ failure and 2/6 were by ARDS.

Conclusions: Major complications such as acute kidney injury, acute respiratory distress syndrome and mortality related to COVID-19 infection observed in our study are lower than those reported in other countries.
PDF (Español)
XML-JATS (Español)


Khan M, Adil SF, Alkhathlan HZ, Tahir M, Saif S, Khan M, et al. COVID-19: A Global Challenge with Old History, Epidemiology and Progress So Far. Molecules. 2020;26(1).

Jordan RE, Adab P, Cheng KK. Covid-19: risk factors for severe disease and death. BMJ. 2020;368.

Mahalingasivam V, Craik A, Tomlinson LA, Ge L, Hou L, Wang Q, et al. A Systematic Review of COVID-19 and Kidney Transplantation. Kidney Int Reports. 2021;6(1):24.

Sharma V, Shaw A, Lowe M, Summers A, van Dellen D, Augustine T. The impact of the COVID-19 pandemic on renal transplantation in the UK. Clin Med (Northfield Il). 2020;20(4):e82.

Khairallah P, Aggarwal N, Awan AA, Vangala C, Airy M, Pan J, et al. The impact of COVID?19 on kidney transplantation and the kidney transplant recipient - One year into the pandemic. Transpl Int. 2021;34(4):612-21.

Khwaja A. KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract. 2012;120(4).

Instituto Nacional de Salud. Modelos de datos COVID-19 [Internet]. INS, 2021 [accedido 2021 nov. 20]. Disponible en:

Arias-Murillo YR, Benavides CA, Salinas MA, Osorio-Arango K, Plazas-Sierra C, Cortés JA. SARS-CoV2/COVID-19 Infection in Transplant Recipients and in Patients on the Organ Transplant Waiting List in Colombia. Transplant Proc. 2021;53(4):1237-44.

Richardson S, Hirsch JS, Narasimhan M, Crawford J, McGinn T, Davidson K, et al. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA. 2020;323(20):2052-9.

Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet (Londres, Inglaterra). 2020;395(10229):1054-62.

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet (Londres, Inglaterra). 2020;395(10223):497-506.

Kute VB, Bhalla AK, Guleria S, Deepak R, Madan B, Ashay S, et al. Clinical Profile and Outcome of COVID-19 in 250 Kidney Transplant Recipients: A Multicenter Cohort Study From India. Transplantation. 2021;105(4):851-60.

Cravedi P, Mothi SS, Azzi Y, Haverly M, Farouk S, Pérez M, et al. COVID?19 and kidney transplantation: Results from the TANGO International Transplant Consortium. Am J Transplant. 2020;20(11):3140-8.

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9.

Toapanta N, Torres IB, Sellarés J, Chamoun B, Serón D, Moreso F. Kidney transplantation and COVID-19 renal and patient prognosis. Clin Kidney J. 2021;14(supl. 1):i21.

Matthay MA, Arabi YM, Siegel ER, Ware L, Bos L, Sinha P, et al. Phenotypes and personalized medicine in the acute respiratory distress syndrome. Intensive Care Med. 2020;46(12):2136-52.

Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med. 2020;180(7):934-43.

Legrand M, Bell S, Forni L, Joannidis M, Koyner J, Liu K, et al. Pathophysiology of COVID-19-associated acute kidney injury. Nat Rev Nephrol. 2021;17(11):751-64.

Hirsch JS, Ng JH, Ross DW, Sharma P, Shah H, Barnett R, et al. Acute kidney injury in patients hospitalized with COVID-19. Kidney Int. 2020;98(1):209-18.

Lin L, Wang X, Ren J, Sun Y, Yu R, Li K, et al. Risk factors and prognosis for COVID-19-induced acute kidney injury: a meta-analysis. BMJ Open. 2020;10(11).

Pezeshgi A, Mubarak M, Djamali A, Mostafavi L, Maghadam-Kia S, Alimohammadi N, et al. COVID-19-associated glomerulopathy and high-risk APOL1 genotype; Basis for a two-hit mechanism of injury? A narrative review on recent findings. J Nephropathol. 2020;10(2):e11.

Friedman DJ. COVID-19 and APOL1: Understanding Disease Mechanisms through Clinical Observation. J Am Soc Nephrol. 2021;32(1):1-2.

Pampols PA, Trujillo H, Melilli E, Urban B, Sandino J, Favá A, et al. Immunosuppression minimization in kidney transplant recipients hospitalized for COVID-19 GRAPHICAL ABSTRACT. Clin Kidney J. 2021;14(4):1229-35.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.




Download data is not yet available.