Explorando el poder de los abordajes transcriptómicos para identificar biomarcadores asociados a daño renal en pacientes con lupus eritematoso sistémico

Exploring the power of transcriptomic approaches to identify biomarkers associated to renal damage in Systemic Lupus Erythematosus patients

Autores/as

DOI:

https://doi.org/10.22265/acnef.8.1.492

Palabras clave:

lupus eritematoso sistémico, nefritis lúpica, biomarcadores, microARNs

Resumen

El lupus eritematoso sistémico (LES) es una enfermedad compleja y altamente heterogénea que afecta múltiples órganos, incluyendo articulaciones, corazón, sistema hematopoyético, sistema nervioso y riñón, siendo este último el de peor pronóstico y el que conlleva a nefritis lúpica (NL). Aunque la etiopatogénesis del LES aún no se conoce con claridad, se cree que la susceptibilidad genética y las modificaciones epigenéticas aberrantes favorecen su desenlace. Para establecer una terapia precisa es necesario evaluar de manera eficiente y objetiva el compromiso de órganos y la actividad de la enfermedad, lo cual es muy difícil por las pocas pruebas de laboratorio clínico disponibles en la actualidad.

En las últimas décadas la búsqueda de nuevos biomarcadores de LES ha sido una tendencia y se han identificado varios promisorios a nivel de genómica, metabolómica, proteómica y transcriptómica. En esta revisión se resume el estado del arte relacionado con estudios transcriptómicos que han identificado diversos transcritos potencialmente útiles como biomarcadores del LES y la NL.

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Publicado

2021-02-02

Cómo citar

1.
Arrieta Bravo V, Rangel Gómez T, Pacheco Lugo L. Explorando el poder de los abordajes transcriptómicos para identificar biomarcadores asociados a daño renal en pacientes con lupus eritematoso sistémico: Exploring the power of transcriptomic approaches to identify biomarkers associated to renal damage in Systemic Lupus Erythematosus patients. Rev. Colomb. Nefrol. [Internet]. 2 de febrero de 2021 [citado 22 de septiembre de 2021];8(1):e492. Disponible en: https://revistanefrologia.org/index.php/rcn/article/view/492