Crescentic glomerulonephritis as an unusual clinical spectrum in a patient with post-streptococcal glomerulonephritis
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acute kidney injury

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Cabarcas Barbosa O, Agudelo Restrepo D, Sanjuanelo Patiño M, Rodelo Ceballos J, Arias L. Crescentic glomerulonephritis as an unusual clinical spectrum in a patient with post-streptococcal glomerulonephritis: Glomerulonefritis proliferativa extracapilar como espectro clínico inusual en un paciente con glomerulonefritis posestreptocócica . Rev. Colomb. Nefrol. [Internet]. 2021 Jan. 26 [cited 2024 May 20];8(1):e485. Available from:


Post-infectious glomerulonephritis can be triggered by viruses, bacteria, fungi, or parasites. These agents can trigger an uncontrolled inflammatory response on the glomerulus and renal tubule, where the formation of immunocomplexes and the activation of the alternative complement pathway participate. Multiple mechanisms have been proposed that involve the generation of antibodies against proteins that are part of the structure of streptococcus and are known as nephrytogenic antigens of which the most recently studied are pyrogenic exotoxin B of streptococcus and glyceraldehyde 3 phosphate dehydrogenase. Post-streptococcal glomerulonephritis usually has a benign course with complications that can be controlled with supportive management. It is rare in adults, however, when it occurs, it has a worse prognosis compared to children. Extracapillary proliferative lesions are unusual in post-streptococcal glomerulonephritis. The case of an adult patient who debuted with rapidly progressive glomerulonephritis secondary to a strep infection is presented.
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