Glomerulonefritis proliferativa extracapilar como espectro clínico inusual en un paciente con glomerulonefritis posestreptocócica

Crescentic glomerulonephritis as an unusual clinical spectrum in a patient with post-streptococcal glomerulonephritis

Autores/as

DOI:

https://doi.org/10.22265/acnef.8.1.485

Palabras clave:

streptococcus, glomerulonefritis, lesión renal aguda

Resumen

La glomerulonefritis post-infecciosa puede ser desencadenada por virus, bacterias hongos o parásitos. Estos agentes pueden desencadenar  una respuesta inflamatoria no controlada sobre el glomérulo y túbulo renal, donde participan la formación de inmunocomplejos y la activación de la via alterna del complemento. Se han planteado múltiples mecanismos que involucran la generación de anticuerpos contra proteínas que hacen parte de la estructura del estreptococo  y son conocidos como antígenos nefritogénicos de los cuales los màs estudiados recientemente son la exotoxina pirogénica B del estreptoco y la gliceraldehido 3 fosfato deshidrogenasa.

La glomerulonefritis post-estreptocóccica usualmente tiene un curso benigno con complicaciones que pueden ser controlados con manejo de soporte. Es infrecuente en el adulto sin embargo, cuando se produce tiene peor pronóstico en comparación con los niños. Las lesiones proliferativas extracapilares son inusuales en la glomerulonefritis post-estreptocòccica.  Se presenta caso de un paciente adulto que debuto con una glomerulonefritis rápidamente progresiva secundario a  una infección por estreptococo.

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Publicado

2021-01-26

Cómo citar

1.
Cabarcas Barbosa O, Agudelo Restrepo D, Sanjuanelo Patiño M, Rodelo Ceballos J, Arias L. Glomerulonefritis proliferativa extracapilar como espectro clínico inusual en un paciente con glomerulonefritis posestreptocócica : Crescentic glomerulonephritis as an unusual clinical spectrum in a patient with post-streptococcal glomerulonephritis. Rev. Colomb. Nefrol. [Internet]. 26 de enero de 2021 [citado 22 de septiembre de 2021];8(1):e485. Disponible en: https://revistanefrologia.org/index.php/rcn/article/view/485