Efficacy and safety of chloroquine, hydroxychloroquine and azithromycin in patients with COVID-19: Summary of evidence
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COVID-19, hydroxychloroquine, azithromycin, adverse drug event, prophylaxis

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Chacón Acevedo K, Pinzón C, Barrera A, Low Padilla E, Yomayusa González N. Efficacy and safety of chloroquine, hydroxychloroquine and azithromycin in patients with COVID-19: Summary of evidence. Rev. Colomb. Nefrol. [Internet]. 2020 Jun. 11 [cited 2022 Aug. 13];7(Supl.2). Available from: https://revistanefrologia.org/index.php/rcn/article/view/469


Introduction: The COVID-19 disease is a health emergency; treatment has not yet been proven.

Objective: To present the available evidence of efficacy and safety of the use of hydroxychloroquine and azithromycin in the prophylaxis and management of patients with COVID-19.

Methods: A rapid literature review was performed; we consulted Medline, scopus and pubmed databases.

Results: Eleven publications were included including rapid literature reviews, observational studies, and clinical trials. No data were found studying prophylaxis with hydroxychloroquine and azithromycin for SARS-CoV-2. Reports of adverse events include episodes of emesis, abdominal pain, nausea, diarrhea, rash, and itching.

Conclusions: The evidence collected suggests that the use of hydroxychloroquine and azithromycin in patients with COVID-19, could abnormal electrocardiogram and increased risk of mortality in-hospital. The effectiveness remains unclear.

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