Recomendaciones para diálisis peritoneal en insuficiencia cardiaca congestiva: prescripción y manejo multidisciplinario
PDF

Palabras clave

insuficiencia cardiaca
síndrome cardiorrenal
diálisis
diálisis peritoneal
soluciones para diálisis

Cómo citar

1.
Uribe Betancur JM, Contreras Villamizar KM, Dávila Guerra M Ángel, Flechas López JA, González Sánchez DA, Jacome Guerrero RL, Ronderos I, Fonseca Zuluaga PA, Arias Barrera C, Saldarriaga Giraldo CI, Correa-Pérez L, Yama-Mosquera E. Recomendaciones para diálisis peritoneal en insuficiencia cardiaca congestiva: prescripción y manejo multidisciplinario . Rev. Colomb. Nefrol. [Internet]. 8 de julio de 2025 [citado 12 de septiembre de 2025];12(2). Disponible en: https://revistanefrologia.org/index.php/rcn/article/view/947

Resumen

Contexto: la insuficiencia cardiaca congestiva refractaria (ICCR) constituye no solo una causa de mortalidad en el paciente con enfermedad cardiovascular, sino que la sintomatología congestiva genera morbilidad, deterioro de la calidad de vida, múltiples hospitalizaciones y aumento de los costos en salud. Las terapias farmacológicas convencionales para manejar la congestión pueden ser retadoras o contraindicadas en pacientes con ICCR y enfermedad renal crónica (ERC), especialmente en condiciones agudas o con síndrome cardiorrenal. La diálisis peritoneal, con sus diversas modalidades, ofrece beneficios significativos para los pacientes con congestión refractaria; no obstante, muchos equipos multidisciplinarios desconocen aspectos específicos de las soluciones y prescripciones de diálisis peritoneal.

Objetivo: proporcionar una síntesis narrativa y recomendaciones multidisciplinarias sobre la diálisis peritoneal en pacientes con ICCR.

Metodología: se realizó una revisión no sistemática de la literatura junto con una perspectiva multidisciplinaria para presentar una síntesis de las recomendaciones actuales para la prescripción de diálisis peritoneal personalizada en falla cardiaca congestiva, con un enfoque centrado en el paciente y su familia.

Resultados: la evidencia extraída muestra la diálisis peritoneal como alternativa terapéutica para paciente con insuficiencia cardiaca congestiva refractaria (ICCR) permitiendo el manejo del volumen, el mantenimiento de la tasa de filtración glomerular con respecto a otras terapias, además de reducir la carga ventricular y la congestión, y mejorar clase funcional. Existe variabilidad en las prácticas de prescripción por lo que se hace una propuesta de prescripción de DP con base fisiológica. A través de las necesidades actuales de la enfermedad se propone un manejo personalizado con un modelo multidisciplinario para el manejo del paciente con ICCR, desde un enfoque centrado en el paciente y la familia.

Conclusiones: la DP es una opción terapéutica viable y costo-efectiva en casos de ICCR con opciones limitadas. Su éxito depende de un enfoque multidisciplinario, de la buena comunicación y del seguimiento clínico, por lo que conocer la fisiología de la DP y ajustar la terapia de forma individualizada mejora los resultados.

https://doi.org/10.22265/acnef.12.2.947
PDF

Citas

Foreman KJ, Marquez N, Dolgert A, Fukutaki K, Fullman N, McGaughey M, et al. Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016-40 for 195 countries and territories. Lancet. 2018;392(10159):2052-90. https://doi.org/10.1016/s0140-6736(18)31694-5

Organización Panamericana de la Salud. Enfermedades del corazón siguen siendo la principal causa de muerte en las Américas [internet]. OPS; 2021. [citado 2021 sept 29]. https://www.paho.org/es/noticias/29-9-2021-enfermedades-corazon-siguen-siendo-principal-causa-muerte-americas

Dzau VJ, Antman EM, Black HR, Hayes DL, Manson JE, Plutzky J, et al. The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part I: Pathophysiology and clinical trial evidence (risk factors through stable coronary artery disease). Circulation. 2006;114(25):2850-70. https://doi.org/10.1161/CIRCULATIONAHA.106.655688

Timóteo AT, Mano TB. Efficacy of peritoneal dialysis in patients with refractory congestive heart failure: a systematic review and meta-analysis. Heart Fail Rev. 2023;28(5):1053-63. https://doi.org/10.1007/s10741-023-10297-3

Bozkurt B, Coats AJS, Tsutsui H, Abdelhamid CM, Adamopoulos S, Albert N, et al. Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure: Endorsed by the Canadian Heart Failure Society, Heart Failure Association of India, Cardiac Society of Australia and New Zealand, and Chinese Heart Failure Association. Eur J Heart Fail. 2021;23(3):352-80. https://doi.org/10.1002/ejhf.2115

Vaduganathan M, Claggett BL, Jhund PS, Cunningham JW, Ferreira JP, Zannad F, et al. Estimating lifetime benefits of comprehensive disease-modifying pharmacological therapies in patients with heart failure with reduced ejection fraction: a comparative analysis of three randomised controlled trials. Lancet. 2020;396(10244):121-8. https://doi.org/10.1016/s0140-6736(20)30748-0

McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42(36):3599-726. https://doi.org/10.1093/eurheartj/ehab368

Greene SJ, Butler J, Albert NM, DeVore AD, Sharma PP, Duffy CI, et al. Medical therapy for heart failure with reduced ejection fraction: the CHAMP-HF registry. J Am Coll Cardiol. 2018;72(4):351-66. https://doi.org/10.1016/j.jacc.2018.04.070

Patel RB, Fonarow GC, Greene SJ, Zhang S, Alhanti B, DeVore AD, et al. Kidney function and outcomes in patients hospitalized with heart failure. J Am Coll Cardiol. 2021;78(4):330-43. https://doi.org/10.1016/j.jacc.2021.05.002

Streng KW, Nauta JF, Hillege HL, Anker SD, Cleland JG, Dickstein K, et al. Non-cardiac comorbidities in heart failure with reduced, mid-range and preserved ejection fraction. Int J Cardiol. 2018;271:132-9. https://doi.org/10.1016/j.ijcard.2018.04.001

Beldhuis IE, Lam CSP, Testani JM, Voors AA, Van Spall HGC, ter Maaten JM, et al. Evidence-based medical therapy in patients with heart failure with reduced ejection fraction and chronic kidney disease. Circulation. 2022;145(7):693-712. https://doi.org/10.1161/circulationaha.121.052792

Mullens W, Damman K, Testani JM, Martens P, Mueller C, Lassus J, et al. Evaluation of kidney function throughout the heart failure trajectory - a position statement from the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2020;22(4):584-603. https://doi.org/10.1002/ejhf.1697

Miller WL. Fluid volume overload and congestion in heart failure: time to reconsider pathophysiology and how volume is assessed. Circ Heart Fail. 2016;9(8):e002922. https://doi.org/10.1161/circheartfailure.115.002922

Dupont M, Mullens W, Tang WH. Impact of systemic venous congestion in heart failure. Curr Heart Fail Rep. 2011;8(4):233-41. https://doi.org/10.1007/s11897-011-0071-7

Gupta R, Testani J, Collins S. Diuretic resistance in heart failure. Curr Heart Fail Rep. 2019;16(2):57-66. https://doi.org/10.1007/s11897-019-0424-1

Shams E, Bonnice S, Mayrovitz HN. Diuretic resistance associated with heart failure. Cureus. 2022;14(1):e21369. https://doi.org/10.7759/cureus.21369

Costanzo MR, Guglin ME, Saltzberg MT, Jessup ML, Bart BA, Teerlink JR, et al. Ultrafiltration versus intravenous diuretics for patients hospitalized for acute decompensated heart failure. J Am Coll Cardiol. 2007;49(6):675-83. https://doi.org/10.1016/j.jacc.2006.07.073

Bart BA, Goldsmith SR, Lee KL, Givert MM, O'Connor CM, Bull DA, et al. Ultrafiltration in decompensated heart failure with cardiorenal syndrome. N Engl J Med. 2012;367(24):2296-304. https://doi.org/10.1056/nejmoa1210357

Schneierson SJ. Continuous peritoneal irrigation in the treatment of intractable edema of cardiac origin. Am J Med Sci. 1949;218(1):76-9. https://doi.org/10.1097/00000441-194907000-00011

Montejo JD, Bajo Rubio MA, del Peso G, Selgas R. Papel de la diálisis peritoneal en el tratamiento de la insuficiencia cardiaca refractaria. Nefrología. 2010;30(1):21-7. http://doi.org/10.3265/Nefrologia.pre2010.Jan.10204

Gadola L, Ormaechea G, Dapueto J, Larre Borges P, Álvarez P. Rol de la diálisis peritoneal en el tratamiento de la insuficiencia cardiaca congestiva estadio D. Insuficiencia Cardiaca. 2014;9(4):153-63. https://www.redalyc.org/articulo.oa?id=321932658002

Yeates K, Zhu N, Vonesh E, Trpeski L, Blake P, Fenton S. Hemodialysis and peritoneal dialysis are associated with similar outcomes for end-stage renal disease treatment in Canada. Nephrol Dial Transplant. 2012;27(9):3568-75. https://doi.org/10.1093/ndt/gfr674

Mehrotra R, Chiu YW, Kalantar-Zadeh K, Bargman J, Vonesh E. Similar outcomes with hemodialysis and peritoneal dialysis in patients with end-stage renal disease. Arch Intern Med. 2011;171(2):110-8. https://doi.org/10.1001/archinternmed.2010.352

Kramer A, Stel V, Zoccali C, Heaf J, Ansell D, Grönhagen-Riska C, et al. An update on renal replacement therapy in Europe: ERA-EDTA Registry data from 1997 to 2006. Nephrol Dial Transplant. 2009;24(12):3557-66. https://doi.org/10.1093/ndt/gfp519

He L, Liu X, Li Z, Abreu Z, Malavade T, Lok CE, et al. Rate of decline of residual kidney function before and after the start of peritoneal dialysis. Perit Dial Int. 2016;36(3):334-9. https://doi.org/10.3747/pdi.2016.00024

Marrón B, Remón C, Pérez-Fontán M, Quirós P, Ortíz A. Benefits of preserving residual renal function in peritoneal dialysis. Kidney Int Suppl. 2008;(108):S42-51. https://doi.org/10.1038/sj.ki.5002600

Jansen MA, Hart AA, Korevaar JC, Dekker FW, Boeschoten EW, Krediet RT, et al. Predictors of the rate of decline of residual renal function in incident dialysis patients. Kidney Int. 2002;62(3):1046-53. https://doi.org/10.1046/j.1523-1755.2002.00505.x

Joachim E, Gardezi AI, Chan MR, Shin JI, Astor BC, Waheed S. Association of pre-transplant dialysis modality and post-transplant outcomes: a meta-analysis. Perit Dial Int. 2017;37(2):259-65. https://doi.org/10.3747/pdi.2016.00011

Miklos Z, Mehrotra R, Duong U, Bunnapradist S, Lukowsky LR, Krishnan M, et al. Dialysis modality and outcomes in kidney transplant recipients. Clin J Am Soc Nephrol. 2012;7(2):332-41. https://doi.org/10.2215/cjn.07110711

Schwenger V, Döhler B, Morath C, Zeier M, Opelz G. The role of pretransplant dialysis modality on renal allograft outcome. Nephrol Dial Transplant. 2011;26(12):3761-6. https://doi.org/10.1093/ndt/gfr132

Perl J, Wald R, McFarlane P, Bargman JM, Vonesh E, Na Y, et al. Hemodialysis vascular access modifies the association between dialysis modality and survival. J Am Soc Nephrol. 2011;22(6):1113-21. https://doi.org/10.1681/asn.2010111155

Foley RN, Guo H, Snyder JJ, Gilbertson DT, Collins AJ. Septicemia in the United States dialysis population, 1991 to 1999. J Am Soc Nephrol. 2004;15(4):1038-45. https://doi.org/10.1097/01.asn.0000119144.95922.c4

Pacheco A, Saffie A, Torres R, Tortella C, Llanos C, Vargas D, et al. Cost/utility study of peritoneal dialysis and hemodialysis in Chile. Perit Dial Int. 2007;27(3):359-63.

Rubin HR, Fink NE, Plantinga LC, Sadler JH, Kliger AS, Powe NR. Patient ratings of dialysis care with peritoneal dialysis vs hemodialysis. JAMA. 2004;291(6):697-703. https://doi.org/10.1001/jama.291.6.697

Merkus MP, Jager KJ, Dekker FW, Boeschoten EW, Stevens P, Krediet RT. Quality of life in patients on chronic dialysis: self-assessment 3 months after the start of treatment. The Necosad Study Group. Am J Kidney Dis. 1997;29(4):584-92. https://doi.org/10.1016/s0272-6386(97)90342-5

Julius M, Kneisley JD, Carpentier-Alting P, Hawthorne VM, Wolfe RA, Port FK. A comparison of employment rates of patients treated with continuous ambulatory peritoneal dialysis vs in-center hemodialysis (Michigan End-Stage Renal Disease Study). Arch Intern Med. 1989;149(4):839-42.

United States Renal Data System. USRDS 2022 Annual Report: End-Stage Renal Disease. Chapter 11: International Comparisons [internet]. Estados Unidos: USRDS; 2022. https://usrds-adr.niddk.nih.gov/2022/end-stage-renal-disease

Karopadi AN, Mason G, Rettore E, Ronco C. Cost of peritoneal dialysis and hemodialysis across the world. Nephrol Dial Transplant. 2013;28(9):2553-9. https://doi.org/10.1093/ndt/gft214

Sanabria M, Devia M, Hernández G, Astudillo K, Trillos C, Uribe M, et al. Outcomes of a peritoneal dialysis program in remote communities within Colombia. Perit Dial Int. 2015;35(1):52-61. https://doi.org/10.3747/pdi.2012.00301

Chui BK, Manns B, Pannu N, Dong J, Wiebe N, Jindal K, et al. Health care costs of peritoneal dialysis technique failure and dialysis modality switching. Am J Kidney Dis. 2013;61(1):104-11. https://doi.org/10.1053/j.ajkd.2012.07.010

Koukou MG, Smyrniotis VE, Arkadopoulos NF, Graspa EI. PD vs HD in post-economic crisis Greece—differences in patient characteristics and estimation of therapy cost. Perit Dial Int. 2017;37(5):568-73. https://doi.org/10.3747/pdi.2016.00292

Karopadi AN. Analysis of costs in renal replacement therapy. Perit Dial Int. 2017;37(5):497-9. https://doi.org/10.3747/pdi.2017.00066

Fernandes A, Matias P, Branco P. Incremental peritoneal dialysis-definition, prescription, and clinical outcomes. Kidney360. 2023;4(2):272-77. https://doi.org/10.34067/kid.0006902022

Shafi T, Jaar BG, Plantinga LC, Fink NE, Sadler JH, Parekh RS, et al. Association of residual urine output with mortality, quality of life, and inflammation in incident hemodialysis patients: the Choices for Healthy Outcomes in Caring for End-Stage Renal Disease (CHOICE) Study. Am J Kidney Dis. 2010;56(2):348-58. https://doi.org/10.1053/j.ajkd.2010.03.020

van der Wal WM, Noordzij M, Dekker FW, Boeschoten EW, Krediet RT, Korevaar JC, et al. Full loss of residual renal function causes higher mortality in dialysis patients; findings from a marginal structural model. Nephrol Dial Transplant. 2011;26(9):2978-83. https://doi.org/10.1093/ndt/gfq856

Perl J, Bargman JM. The importance of residual kidney function for patients on dialysis: a critical review. Am J Kidney Dis. 2009;53(6):1068-81. https://doi.org/10.1053/j.ajkd.2009.02.012

Van Biesen W, Dequidt C, Vanholder R, Lameire N. The impact of healthy start peritoneal dialysis on the evolution of residual renal function and nutrition parameters. Adv Perit Dial. 2002;18:44-8.

Berlanga JR, Marrón B, Reyero A, Caramelo C, Ortiz A. Peritoneal dialysis retardation of progression of advanced renal failure. Perit Dial Int. 2002;22(2):239-42.

Viglino G, Neri L, Barbieri S. Incremental peritoneal dialysis: effects on the choice of dialysis modality, residual renal function and adequacy. Kidney Int Suppl. 2008;(108):S52-5. https://doi.org/10.1038/sj.ki.5002601

Borràs Sans M, Chacón Camacho A, Cerdá Vilaplana C, Usón Nuño A, Fernández E. Diálisis peritoneal incremental: resultados clínicos y preservación de la función renal residual. Nefrología. 2016;36(3):217-332. http://doi.org/10.1016/j.nefro.2016.01.006

Lu R, Muciño-Bermejo MJ, Ribeiro LC, Tonini E, Estremadoyro C, Samoni S, et al. Peritoneal dialysis in patients with refractory congestive heart failure: a systematic review. Cardiorenal Med. 2015;5(2):145-56. https://doi.org/10.1159/000380915

Hedau S, Chakravarthi R, Reddy V. Ultrafiltration by peritoneal route in refractory chronic congestive cardiac failure. Indian J Nephrol. 2018;28(4):298-302. https://doi.org/10.4103/ijn.ijn_12_17

Zemel D, Imholz AL, de Waart DR, Dinkla C, Struijk DG, Krediet RT. Appearance of tumor necrosis factor-alpha and soluble TNF-receptors I and II in peritoneal effluent of CAPD. Kidney Int. 1994;46(5):1422-30. https://doi.org/10.1038/ki.1994.414

Li PKT, Chow KM, Cho Y, Fan S, Figueiredo AE, Harris T, et al. ISPD peritonitis guideline recommendations: 2022 update on prevention and treatment. Perit Dial Int. 2022;42(2):110-53. https://doi.org/10.1177/08968608221080586

Daugirdas JT, Blake PG, Ing TS. Physiology of Peritoneal Dialysis. En: Daugirdas JT, Blake PG, Ing TS, editores. Handbook of Dyalysis. 2.a ed. Barcelona: Masson, S.A.; 2001. p. 321-336.

Twardowski ZJ. Pathophysiology of peritoneal transport. Contrib Nephrol. 2006;150:13-9. https://doi.org/10.1159/000093443

Ronco C, Brendolan A, La Greca G. The peritoneal dialysis system. Nephrol Dial Transplant. 1998;13(supl. 6):94-9. https://doi.org/10.1093/ndt/13.suppl_6.94

Flessner MF. Peritoneal transport physiology: insights from basic research. J Am Soc Nephrol. 1991;2(2):122-35. https://doi.org/10.1681/asn.v22122

Flessner MF. Distributed model of peritoneal transport: implications of the endothelial glycocalyx. Nephrol Dial Transplant. 2008;23(7):2142-6. https://doi.org/10.1093/ndt/gfn055

Devuyst O, Goffin E. Water and solute transport in peritoneal dialysis: models and clinical applications. Nephrol Dial Transplant. 2008;23(7):2120-3. https://doi.org/10.1093/ndt/gfn298

van Biesen W, Heimburger O, Krediet R, Rippe B, La Milia V, Covic A, et al. Evaluation of peritoneal membrane characteristics: clinical advice for prescription management by the ERBP working group. Nephrol Dial Transplant. 2010;25(7):2052-62. https://doi.org/10.1093/ndt/gfq100

Abu-Alfa AK, Burkart J, Piraino B, Pulliam J, Mujais S. Approach to fluid management in peritoneal dialysis: a practical algorithm. Kidney Int Suppl. 2002;(81):S8-16. https://doi.org/10.1046/j.1523-1755.62.s81.3.x

Mujais S, Vonesh E. Profiling of peritoneal ultrafiltration. Kidney Int Suppl. 2002;81:S17-22. https://doi.org/10.1046/j.1523-1755.62.s81.4.x

Heimbürger O, Waniewski J, Werynski A, Lindholm B. A quantitative description of solute and fluid transport during peritoneal dialysis. Kidney Int. 1992;41(5):1320-32. https://doi.org/10.1038/ki.1992.196

Cueto-Manzano AM. Rapid solute transport in the peritoneum: physiologic and clinical consequences. Perit Dial Int. 2009;29(supl. 2):S90-5.

Krediet RT, Boeschoten EW, Struijk DG, Arisz L. Differences in the peritoneal transport of water, solutes and proteins between dialysis with two- and with three-litre exchanges. Nephrol Dial Transplant. 1988;3(2):198-204.

Leypoldt JK. Solute transport across the peritoneal membrane. J Am Soc Nephrol. 2002;13(supl. 1):S84-91.

Rippe B. Free water transport, small pore transport and the osmotic pressure gradient: three-pore model of peritoneal transport. Nephrol Dial Transplant. 2008;23(7):2147-53. https://doi.org/10.1093/ndt/gfn049

Wolfson M, Ogrinc F, Mujais S. Review of clinical trial experience with icodextrin. Kidney Int Suppl. 2002;62(supl. 81):S46-52. https://doi.org/10.1046/j.1523-1755.62.s81.7.x

Twardowski ZJ. Pathophysiology of peritoneal transport. Contrib Nephrol. 2006;150:13-9. https://doi.org/10.1159/000093443

Ronco C, Brendolan A, La Greca G. The peritoneal dialysis system. Nephrol Dial Transplant. 1998;13(supl. 6):94-9. https://doi.org/10.1093/ndt/13.suppl_6.94

Ajibowo AO, Okobi OE, Emore E, Soladoye E, Sike CG, Odoma VA, et al. Cardiorenal syndrome: a literature review. Cureus. 2023;15(7):e41252. https://doi.org/10.7759/cureus.41252

McCallum W, Sarnak MJ. Cardiorenal syndrome in the hospital. Clin J Am Soc Nephrol. 2023;18(7):933-45. https://doi.org/10.2215/cjn.0000000000000064

McCallum W, Testani JM. Updates in cardiorenal syndrome. Med Clin North Am. 2023;107(4):763-80. https://doi.org/10.1016/j.mcna.2023.03.011

Pernias V, González M, Miñana G, Górriz JL, Juan I, Chorro FJ, et al. Refractory congestive heart failure: when the solution is outside the heart. ESC Heart Fail. 2020;7(1):311-4. https://doi.org/10.1002/ehf2.12554

Twardowski ZJ. Clinical value of standardized equilibration tests in CAPD patients. Blood Purif. 1989;7(2-3):95-108. https://doi.org/10.1159/000169582

Saxena R. PET Testing has utility in the prescription of peritoneal dialysis: commentary. Kidney360. 2024;5(12):1797-8. https://doi.org/10.34067/KID.0000000000000409

Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.