Hand grip strength and biomarkers in patients with chronic kidney disease on hemodialysis
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Handgrip strengh
Chronic kidney disease

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Ángel Bustos IC, Apolinar Joven LY, Campos-Rodríguez A, Vásquez Montoya MG, Patiño Palma BE. Hand grip strength and biomarkers in patients with chronic kidney disease on hemodialysis. Rev. Colomb. Nefrol. [Internet]. 2024 Apr. 1 [cited 2024 Jul. 25];11(1). Available from: https://revistanefrologia.org/index.php/rcn/article/view/699


Background: Chronic kidney disease (CKD) is associated with impairment of physical capacity as a consequence of systemic involvement mainly related to the presence of anemia, sarcopenia, malnutrition, and inactivity, resulting in decreased functional capacity. Measurement of hand grip strength (HGS) is a useful marker of nutritional status, reflecting lean muscle mass, assessing functional status, and predicting prognosis and survival in end-stage renal disease (ESRD).

Purpose: To determine the relationship between hand grip strength and serological biomarkers in patients with CKD on hemodialysis.

Methodology: a study with a quantitative approach, cross-sectional design, and correlational scope. Registration of the information on the REDCap (Research Electronic Data Capture) platform, data collection was between April and November 2022. HGS measured with a Biometrics G200 dynamometer, and serological data was analyzed: hemoglobin, triglycerides, potassium, total cholesterol, and albumin.

Results: statistically significant differences were found between the sexes in terms of hemoglobin, triglycerides, total cholesterol, and hand grip strength levels. There is a directly proportional relationship between hand grip strength with HB (Rho=0.31; p=<0.00), albumin (Rho=0.42; p=<0.00), and potassium (Rho=031; p=<0.00).

Conclusions: The theoretical basis for this article can be conclusive regarding the relationship between frailty and sarcopenia, with some important biomarkers in this population, which may allow the analysis of decreased strength as an influencing factor in the patient's quality of life. The theory supports a direct relationship between pathophysiological factors and frailty, which translates into decreased functional strength in patients with CKD.

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García-Maset R, Bover J, De La Morena JS, Diezhandino MG, Del Hoyo JC, Martín JE, et al. Documento de información y consenso para la detección y manejo de la enfermedad renal crónica. Nefrología. 2022 my. 1;42(3):233-64. https://doi.org/10.1016/j.nefro.2021.07.010

Moreno Collazos JE, Cruz Bermúdez HF. Ejercicio físico y enfermedad renal crónica en hemodiálisis. Rev Nefrol Dial Traspl. 2015;35(4):212-9. https://www.revistarenal.org.ar/index.php/rndt/article/view/44

Benjumea Salgado ÁM. Fragilidad en la enfermedad renal crónica. Rev Elec Biomed. 2019;2. https://biomed.uninet.edu/2019/n2/benjumea.pdf

Portilla Franco ME, Tornero Molina F, Gil Gregorio P. La fragilidad en el anciano con enfermedad renal crónica. Nefrología. 2016;36(6):609-15. https://doi.org/10.1016/j.nefro.2016.03.020

Chang YT, Wu HL, Guo H, Cheng Y, Tseng CC, Wang MC, et al. Handgrip Strength is an independent predictor of renal outcomes in patients with chronic kidney diseases. Nephrol Dial Transpl. 2011 mzo. 28;26(11):3588-95. https://doi.org/10.1093/ndt/gfr013

González Ovando IY, Vega Malagón G. Fisioterapia nefrológica: mejora de la calidad de vida mediante un programa de acondicionamiento físico en pacientes con enfermedad renal crónica en una unidad de hemodiálisis en México. Eur Sci J. 2017 ag. 31;13(24):405. https://doi.org/10.19044/esj.2017.v13n24p405

Vargas-Pinilla OC, Rodríguez-Grande EI. Reproducibility and agreement between three positions for handgrip assessment. Sci Rep. 2021 jun. 18;11(1). https://doi.org/10.1038/s41598-021-92296-8

Acosta-Benito MÁ, Martín-Lesende I. Fragilidad en atención primaria: diagnóstico y manejo multidisciplinar. Aten Prim. 2022 sept. 1;54(9):102395. https://doi.org/10.1016/j.aprim.2022.102395

Cobacho-Salmoral O, Parra-Martos L, Laguna-Castro M, Crespo-Montero R. Factores asociados a la fragilidad en el paciente en tratamiento renal sustitutivo con diálisis. Una revisión sistemática. Enferm nefrol. 2021;24(3):233-48. http://dx.doi.org/10.37551/s2254-28842021021

Silva-Fhon JR, Rojas-Huayta VM, Aparco-Balboa JP, Céspedes-Panduro B, Partezani-Rodrigues RA. Sarcopenia y albúmina sanguínea: revisión sistemática con metaanálisis. Biomédica. 2021 sept. 22;41(3):590-603. https://doi.org/10.7705/biomedica.5765

Cabrerizo S, Cuadras D, Gómez-Busto F, Artaza-Artabe I, Marín-Ciancas F, Malafarina V. Serum albumin and Health in Older People: Review and meta analysis. Maturitas. 2015 my. 1;81(1):17-27. https://doi.org/10.1016/j.maturitas.2015.02.009

Amanzadeh J, Reilly Jr RF. Hypophosphatemia: An evidence-based approach to its clinical consequences and management. Nature Clin Pract Nephrol. 2006 mzo. 1;2(3):136-48. https://doi.org/10.1038/ncpneph0124

Van Dronkelaar C, van Velzen A, Abdelrazek M, van der Steen A, Weijs PJM, Tieland M. Minerals and sarcopenia; The role of calcium, iron, magnesium, phosphorus, potassium, selenium, sodium, and zinc On muscle mass, muscle strength, and physical performance in older adults: a Systematic review. J Am Med Dir Assoc. 2018 en. 1;19(1):6-11.e3. https://doi.org/10.1016/j.jamda.2017.05.026

Picard K, Griffiths MJ, Mager DR, Richard C. Handouts for Low-Potassium diets disproportionately restrict fruits and vegetables. J Renal Nutr. 2021 mzo. 1;31(2):210-4. https://doi.org/10.1053/j.jrn.2020.07.001

Bernier-Jean A, Wong G, Saglimbene V, Ruospo M, Palmer SC, Natale P, et al. Dietary potassium intake and All-Cause mortality in adults treated with hemodialysis. Clin J Am Soc Nephrol. 2021 dic. 1;16(12):1851-61. https://doi.org/10.2215/cjn.08360621

Dolson GM, Ellis KJ, Johnson ML, Adrogué HJ. Incidence and consequences of total body potassium depletion in chronic hemodialysis patients. Front Biosci. 2003 en. 1;8(1):a126-32. https://doi.org/10.2741/1094

Wieërs ML, Mulder J, Rotmans JI, Hoorn EJ. Potassium and the kidney: a reciprocal relationship with clinical relevance. Pediatr Nephrol. 2022 febr. 23;37(10):2245-54. https://doi.org/10.1007/s00467-022-05494-5

Garza-González EL, Gallegos-Flores EA, Hernández-Gutiérrez J, Flores-Monsivais JE, Nava-González EJ. Biomarcadores moleculares en la predicción de sarcopenia. Rev Salud Pública Nutr. 2017;16(1):23-32. http://dx.doi.org/10.29105/respyn16.1-4

Semmarath W, Seesen M, Yodkeeree S, Sapbamrer R, Ayood P, Malasao R, et al. The association between frailty indicators and blood-based biomarkers in early old community dwellers of Thailand. Int J Environ Res Public Health. 2019;16(18):3457. http://dx.doi.org/10.3390/ijerph16183457

Pérez-Zepeda MU, García-Peña C, Carrillo-Vega MF. Individual and cumulative association of commonly used biomarkers on frailty: a cross-sectional analysis of the Mexican Health and Aging Study. Aging Clin Exp Res. 2019;31(10):1429-34. http://dx.doi.org/10.1007/s40520-019-01127-4

Cable N, Hiyoshi A, Kondo N, Ainda J, Sjöqvist H, Kondo K. Identifying Frail-Related Biomarkers among Community-Dwelling Older Adults in Japan: A Research Example from the Japanese Gerontological Evaluation Study. BioMed Research International. 2018; 2018: 5362948. https://doi.org/10.1155/2018/5362948

Tsai PH, Yang HC, Lin C, Sung CC, Chu P, Hsu YJ. Association of serum phosphate with low handgrip strength in patients with advanced chronic kidney disease. Nutrients. 2021;13(10):3605. http://dx.doi.org/10.3390/nu13103605

Lee YL, Jin H, Lim JY, Lee SY. Relationship between low handgrip strength and chronic kidney disease: KNHANES 2014-2017. J Ren Nutr. 2021;31(1):57-63. http://dx.doi.org/10.1053/j.jrn.2020.03.002

Nakagawa C, Inaba M, Ishimura E, Yamakawa T, Shoji S, Okuno S. Association of increased serum ferritin with impaired muscle strength/quality in hemodialysis patients. J Ren Nutr. 2016;26(4):253-7. http://dx.doi.org/10.1053/j.jrn.2016.01.011

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