Biochemical Approach of Acid-Base Disturbances
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Keywords

metabolic acidosis
respiratory acidosis
metabolic alkalosis
respiratory alkalosis
Acid-base equilibrium
alkalemia
acidemia
alkalosis
acidosis
critical care
blood gas analysis
cellular respiration

How to Cite

1.
Nitsch Prado A. Biochemical Approach of Acid-Base Disturbances. Rev. Colomb. Nefrol. [Internet]. 2023 Jul. 25 [cited 2024 Apr. 20];10(3). Available from: https://revistanefrologia.org/index.php/rcn/article/view/612

Abstract

Background: The current paradigms in arterial blood gas analysis are based on mathematical or physicochemical models that require complex algorithms for interpretation. This leads to avoidance or dislike from health care professionals.

Purpose: To formulate a new approach to the analysis and classification of acid base disturbances.

Methodology: we conducted a systematic review of the related literature and a paradigm shift for data interpretation.

Results: Acid-base disorders can be grouped and managed according to the underlying biochemical processes.

Conclusions: This proposal represents a new classification, which groups acid base disorders according to the underlying causal biochemical process. Disorders with an elevated anion gap relate to alterations in cellular respiration (energy/ATP production)- All disturbances with  normal anion gap relate to transmembrane ion exchange.

https://doi.org/10.22265/acnef.10.3.612
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