Acute Myeloid Leukemia in a Geriatric Patient with a History of Minimal Change Disease


Acute myelocytic leukemia
minimal change disease
paraneoplastic glomerulonephritis

How to Cite

Alp A, Pektaş G, Çiriş İbrahim M. Acute Myeloid Leukemia in a Geriatric Patient with a History of Minimal Change Disease. Rev. Colomb. Nefrol. [Internet]. 2022 Nov. 11 [cited 2024 May 20];9(3). Available from:


Background: The increase in the incidence of malignancies globally, and the increase in the usage frequency and types of new anti-cancer drugs, have made onconephrology more important in our clinical practice. Paraneoplastic glomerulonephritis constitutes an important part of this approach as well.

Purpose: The association of AML-nephrotic syndrome is relatively less defined in the literature compared to other hematological malignancies.

Case presentation: In this article, we present a case of acute myelocytic leukemia in a patient who was diagnosed with minimal change disease many years ago.

Discussion and Conclusion: Hematological malignancies-MCD association, is one of the best described examples of paraneoplastic glomerulonephritis. We know that cancer can be clinically diagnosed years after the detection of renal disease in paraneoplastic glomerulonephritis. In this case; rationality of follow-up, not only during the diagnosis of glomerulonephritis but also periodically in the long term, especially in clinical situations such as MCD that occur in geriatric patients, should be discussed.


Lai KW, Wei CL, Tan LK, Tan PH, Chiang GSC, Lee CGL, et al. Overexpression of interleukin-13 induces minimal-change-like nephropathy in rats. J Am Soc Nephrol. 2007;18(5):1476-1485.

Audard V, Larousserie F, Grimbert P, Abtahi M, Sotto JJ, Boue F, et al. Minimal change nephrotic syndrome and classical Hodgkin's lymphoma: report of 21 cases and review of the literature. Kidney Int. 2006;69(12):2251-2260.

Pani A, Porta C, Cosmai L, Melis P, Floris M, Piras D, et al. Glomerular diseases and cancer: evaluation of underlying malignancy. J Nephrol. 2016;29(2):143-152.

Bjørneklett R, Vikse BE, Svarstad E, Aasarød K, Bostad L, Langmark F, et al.. Long-term risk of cancer in membranous nephropathy patients. Am J Kidney Dis. 2007;50(3):396-403.

Izzedine H, Escudier B, Lhomme C, Pautier P, Rouvier P, Gueutin V, et al. Kidney diseases associated with anti-vascular endothelial growth factor (VEGF): an 8-year observational study at a single center. Medicine (Baltimore). 2014;93(24):333-339.

Taniguchi K, Fujioka H, Torashima Y, Yamaguchi J, Izawa K, Kanematsu T. Rectal cancer with paraneoplastic nephropathy: association of vascular endothelial growth factor. Dig Surg. 2004;21(5-6):455-457.

Chahal J, Drachenberg C, Pallone T. Acute Kidney Injury and Nephrotic-Range Proteinuria in a Patient 18 Months After Bone Marrow Transplantation. Am J Kidney Dis. 2017;70(4):A12-A15.

Sahiner S, Ayli MD, Yüksel C, Oneç K, Abayli E. Membranous nephropathy associated with acute myeloid leukemia. Transplant Proc. 2004;36(9):2618-2619.

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