Background: The increase in the incidence of malignancies globally, and the increase in the usage frequency and types of new anti-cancer drugs, have made onconephrology more important in our clinical practice. Paraneoplastic glomerulonephritis constitutes an important part of this approach as well.
Purpose: The association of AML-nephrotic syndrome is relatively less defined in the literature compared to other hematological malignancies.
Case presentation: In this article, we present a case of acute myelocytic leukemia in a patient who was diagnosed with minimal change disease many years ago.
Discussion and Conclusion: Hematological malignancies-MCD association, is one of the best described examples of paraneoplastic glomerulonephritis. We know that cancer can be clinically diagnosed years after the detection of renal disease in paraneoplastic glomerulonephritis. In this case; rationality of follow-up, not only during the diagnosis of glomerulonephritis but also periodically in the long term, especially in clinical situations such as MCD that occur in geriatric patients, should be discussed.
Lai KW, Wei CL, Tan LK, Tan PH, Chiang GSC, Lee CGL, et al. Overexpression of interleukin-13 induces minimal-change-like nephropathy in rats. J Am Soc Nephrol. 2007;18(5):1476-1485. https://doi.org/10.1681/asn.2006070710
Audard V, Larousserie F, Grimbert P, Abtahi M, Sotto JJ, Boue F, et al. Minimal change nephrotic syndrome and classical Hodgkin's lymphoma: report of 21 cases and review of the literature. Kidney Int. 2006;69(12):2251-2260. https://doi.org/10.1038/sj.ki.5000341
Pani A, Porta C, Cosmai L, Melis P, Floris M, Piras D, et al. Glomerular diseases and cancer: evaluation of underlying malignancy. J Nephrol. 2016;29(2):143-152. https://doi.org/10.1007/s40620-015-0234-9
Bjørneklett R, Vikse BE, Svarstad E, Aasarød K, Bostad L, Langmark F, et al.. Long-term risk of cancer in membranous nephropathy patients. Am J Kidney Dis. 2007;50(3):396-403. https://doi.org/10.1053/j.ajkd.2007.06.003
Izzedine H, Escudier B, Lhomme C, Pautier P, Rouvier P, Gueutin V, et al. Kidney diseases associated with anti-vascular endothelial growth factor (VEGF): an 8-year observational study at a single center. Medicine (Baltimore). 2014;93(24):333-339. https://doi.org/10.1097/md.0000000000000207
Taniguchi K, Fujioka H, Torashima Y, Yamaguchi J, Izawa K, Kanematsu T. Rectal cancer with paraneoplastic nephropathy: association of vascular endothelial growth factor. Dig Surg. 2004;21(5-6):455-457. https://doi.org/10.1159/000083474
Chahal J, Drachenberg C, Pallone T. Acute Kidney Injury and Nephrotic-Range Proteinuria in a Patient 18 Months After Bone Marrow Transplantation. Am J Kidney Dis. 2017;70(4):A12-A15. https://doi.org/10.1053/j.ajkd.2017.06.018
Sahiner S, Ayli MD, Yüksel C, Oneç K, Abayli E. Membranous nephropathy associated with acute myeloid leukemia. Transplant Proc. 2004;36(9):2618-2619. https://doi.org/10.1016/j.transproceed.2004.09.082
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