Hyperkalemia associated with the administration of trimethoprim sulfamethoxazole
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Adverse Drug Event
trimethoprim sulfamethoxazole
case report

How to Cite

Zuluaga C, Berrouet Mejia MC, Cárdenas JJ. Hyperkalemia associated with the administration of trimethoprim sulfamethoxazole . Rev. Colomb. Nefrol. [Internet]. 2022 Aug. 11 [cited 2024 Jul. 16];9(2). Available from: https://revistanefrologia.org/index.php/rcn/article/view/577


Introduction: Trimethoprim and sulfamethoxazole is a combination of antimicrobial agents, with its use some adverse reactions have been described, including electrolyte disturbances such as hyperkalemia.

Purpose: The review of this case is proposed as a strategy that allows providing iper to health personnel for the detection iper adverse iperc such as ipercalcemia associated with the administration of trimeoprim sulfamethoxazole, antimicrobials widely used in emergency services, hospitalization, special/intensive care units  and even on an outpatient basis.

Case presentation: A patient case report is presented without the additional risk factors described in the literature for the development of hyperkalemia, allowing through its discussion to sensitize health personnel about this effect, also being the first case reported in our environment in a patient under 50 years old.

Discussion and conclusion: Since 1983, the first cases of hypercalcaemia associated with the administration of these antimicrobials have been recorded, describing different risk factors such as age, the coexistence of renal failure, the use of potassium-sparing diuretics, antihypertensive inhibitors of the angiotensin-converting enzyme and receptors. Of angiotensin 2, although it is important to closely monitor these risk groups, this event can also occur in their absence, as in the case of this patient.


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