Co-Infección por Cryptococcus neoformans en paciente trasplantado renal con COVID-19. Reporte de caso.
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Keywords

COVID-19, SASRS COV2, Cryptococcus, kidney transplantation, immunosuppression.

How to Cite

1.
Torrez Serrano RE, Rosselli San Martin C, Olivares Algarin O, Agudelo Gonzalez S, Carrillo Ayerbe MP, Coral Zuñiga VE. Co-Infección por Cryptococcus neoformans en paciente trasplantado renal con COVID-19. Reporte de caso. Rev. Colomb. Nefrol. [Internet]. 2021 Mar. 16 [cited 2024 Mar. 28];8(2):e521. Available from: https://revistanefrologia.org/index.php/rcn/article/view/521

Abstract

The severe acute respiratory syndrome by coronavirus 2 (SARS-CoV-2), which causes the disease COVID-19, represents  one of the most deleterious health emergencies of the last two decades; of which there are still innumerable unknowns about the course and handling of atypical presentations. Therefore, it is important to publish clinical cases of interest in a special population, such as kidney transplant recipients, who may have a greater risk of contracting the disease due to their immunosuppression and frequent contact with the medical care system.

Co-infection with other respiratory viruses is not uncommon in the transplanted population with COVID-19, and the association with opportunistic germs such as Mycobacteria, Cytomegalovirus, Pneumocystis jirovecii and fungi, such as Cryptococcus neoformans is unknown, but it is possible that this association could worsen the severity of the systemic and pulmonary involvement.

We present the case of a 45-year-old man who was admitted to the emergency service, with a history of renal transplantation from a cadaveric donor, he presented ACUTE RESPIRATORY DIFFICULTY SYNDROME (ARDS) and ventilatory failure due to infection by SARS-CoV-2. Also confirmed systemic infection by Cryptococcus neoformans without compromise of the central nervous system. Management was started with invasive mechanical ventilation, glucocorticoid, liposomal amphotericin B and he died 12 days after admission.

https://doi.org/10.22265/acnef.8.2.521
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References

1. OMS(21 Septiembre del 2020). Coronavirus disease (COVID-19) Weekly Epidemiological Update and Weekly Operational Update. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports
2. Jiang, Guanmin & Renc, Xiaoshuai & Liu, Yan & Chen, Hongtao & Liu, Wei & Guo, Zhaowang & Zhang, Yaqin & Chen, Chaoqun & Zhou, Jianhui & Xiao, Qiang & Shan, Hong. (2020). Application and optimization of RT-PCR in diagnosis of SARS-CoV-2 infection. 10.1101/2020.02.25.20027755.
3. Jin Y, Yang H, Ji W, et al. Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Viruses. 2020;12(4):372. Published 2020 Mar 27. doi:10.3390/v12040372
4. Kakodkar P, Kaka N, Baig MN. A Comprehensive Literature Review on the Clinical Presentation, and Management of the Pandemic Coronavirus Disease 2019 (COVID-19). Cureus. 2020;12(4):e7560. Published 2020 Apr 6. doi:10.7759/cureus.7560
5. Organización Panamericana de la Salud / Organización Mundial de la Salud. Actualización epidemiológica: Enfermedad del Coronavirus (COVID-19). 18 de septiembre de 2020, Washington, D.C: OPS/OMS; 2020. https://www.paho.org/es/documentos/actualizacion-epidemiologica-enfermedad-por-coronavirus-covid-19-18-septiembre-2020
6. Instituto Nacional de Salud. Semana epidemiológica 36: 30 de agosto al 05 de septiembre de 2020. Boletin Epidemiológico Semanal. Ins Nal Salud. https://doi.org/10.33610/23576189.2020.36
7. Mikami, T., Miyashita, H., Yamada, T. et al. Risk Factors for Mortality in Patients with COVID-19 in New York City. J GEN INTERN MED (2020). https://doi.org/10.1007/s11606-020-05983-z
8. Luis D’Marco, María Jesús Puchades, María Romero-Parra, Elena Gimenez-Civera, María José Soler, Alberto Ortiz, José Luis Gorriz, Coronavirus disease 2019 in chronic kidney disease, Clinical Kidney Journal, Volume 13, Issue 3, June 2020, Pages 297–306, https://doi.org/10.1093/ckj/sfaa104
9. López, Veronica & Vazquez, Teresa & Alonso-Titos, Juana & Cabello, Mercedes & Alonso, Angel & Beneyto, Isabel & Crespo, Marta & Díaz-Corte, Carmen & Franco, Antonio & González-Roncero, Francisco & Gutiérrez, Elena & Guirado, Luis & Jimenez, Carlos & Jironda, Cristina & Lauzurica, Ricardo & Llorente, Santiago & Mazuecos, Auxiliadora & Paul, Javier & Rodríguez-Benot, Alberto & Hernández, Domingo. (2020). Recomendaciones en el manejo de la pandemia por coronavirus SARS-CoV-2 (Covid-19) en pacientes con trasplante renal. Nefrología. 40. 10.1016/j.nefro.2020.03.002.
10. Bossini, Nicola & Alberici, Federico & Delbarba, Elisa & Valerio, Francesca & Manenti, Chiara & Possenti, Stefano & Econimo, Laura & Maffei, Camilla & Pola, Alessandra & Terlizzi, Vincenzo & Salviani, Chiara & Moscato, Marianna & Pasquali, Stefano & Zambetti, Nicole & Tonoli, Michela & Affatato, Stefania & Pecchini, Paola & Viola, Fabio & Malberti, Fabio & Scolari, Francesco. (2020). Kidney transplant patients with SARS-CoV-2 infection: The Brescia Renal COVID task force experience. American Journal of Transplantation. 10.1111/ajt.16176.
11. Favà A, Cucchiari D, Montero N, et al. Clinical characteristics and risk factors for severe COVID-19 in hospitalized kidney transplant recipients: A multicentric cohort study [published online ahead of print, 2020 Aug 10]. Am J Transplant. 2020;10.1111/ajt.16246. doi:10.1111/ajt.16246
12. Cravedi P, Mothi SS, Azzi Y, Haverly M, Farouk SS, Pérez?Sáez MJ, et al.. COVID?19 and kidney transplantation: Results from the TANGO International Transplant Consortium. American Journal of Transplantation 2020. doi:10.1111/ajt.16185.
13. Montagud-Marrahi E, Cofan F, Torregrosa JV, et al. Preliminary data on outcomes of SARS-CoV-2 infection in a Spanish single center cohort of kidney recipients. American Journal of Transplantation. 2020; http://doi.org/10.1111/ajt.15970
14. Torres RE, Montero C, Benavides C, Malaver N, García Padilla P, Acevedo A, et al.. Recomendaciones de la asociación colombiana de nefrología en trasplante renal durante la pandemia por coronavirus (covid-19). Revista Colombiana De Nefrología 2020;7:9–10. doi:10.22265/acnef.7.supl.2.447.
15. Chan JFW, Yao Y, Yeung M-L, Deng W, Bao L, Jia L, et al. Treatment with lopinavir/ritonavir or interferon-?1b improves outcome of MERS-CoV infection in a non-human primate model of common marmoset Downloaded from [Internet]. Vol. 5, Journal of Infectious Diseases Advance Access. 2015. Disponible en: http://jid.oxfordjournals.org/
16. Zaza G, Tomei P, Ria P, Granata S, Boschiero L, Lupo A. Systemic and nonrenal adverse effects occurring in renal transplant patients treated with mTOR inhibitors. Vol. 2013, Clinical and Developmental Immunology. 2013
17. Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report. New England Journal of Medicine 2020. doi:10.1056/nejmoa2021436.
18. Demir, Erol & Uyar, Murathan & Parmaksiz, Ergun & Sinangil, Ay?e & Yelken, Berna & Dirim, Ahmet & Merhametsiz, Ozgur & Yadigar, Serap & Ucar, Zuhal & Ucar, Ali & Demir, Mehmet & Mese, Meral & Akin, Emin & Garayeva, Nurana & Safak, Seda & Oto, Ozgur & Yazici, Halil & Turkmen, Aydin. (2020). COVID-19 in kidney transplant recipients: A multicenter experience in Istanbul. Transplant Infectious Disease. 10.1111/tid.13371.
19. Fishman JA. Chapter 31 - Infection in Kidney Transplant Recipients. Kidney Transplantation - Principles and Practice. 2019 : 517–538. doi: 10.1016/B978-0-323-53186-3.00031-0
20. Seok H, Huh K, Cho SY, et al. Invasive Fungal Diseases in Kidney Transplant Recipients: Risk Factors for Mortality. J Clin Med. 2020;9(6):1824. Published 2020 Jun 11. doi:10.3390/jcm9061824
21. Zhu X, Ge Y, Wu T, Zhao K, Chen Y, Wu B, et al.. Co-infection with respiratory pathogens among COVID-2019 cases. Virus Research 2020;285:198005. doi:10.1016/j.virusres.2020.198005.
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