Co-Infección por Cryptococcus neoformans en paciente trasplantado renal con COVID-19. Reporte de caso.
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COVID-19, SASRS COV2, Cryptococcus, kidney transplantation, immunosuppression.

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Torrez Serrano RE, Rosselli San Martin C, Olivares Algarin O, Agudelo Gonzalez S, Carrillo Ayerbe MP, Coral Zuñiga VE. Co-Infección por Cryptococcus neoformans en paciente trasplantado renal con COVID-19. Reporte de caso. Rev. Colomb. Nefrol. [Internet]. 2021 Mar. 16 [cited 2024 Jul. 16];8(2):e521. Available from:


The severe acute respiratory syndrome by coronavirus 2 (SARS-CoV-2), which causes the disease COVID-19, represents  one of the most deleterious health emergencies of the last two decades; of which there are still innumerable unknowns about the course and handling of atypical presentations. Therefore, it is important to publish clinical cases of interest in a special population, such as kidney transplant recipients, who may have a greater risk of contracting the disease due to their immunosuppression and frequent contact with the medical care system.

Co-infection with other respiratory viruses is not uncommon in the transplanted population with COVID-19, and the association with opportunistic germs such as Mycobacteria, Cytomegalovirus, Pneumocystis jirovecii and fungi, such as Cryptococcus neoformans is unknown, but it is possible that this association could worsen the severity of the systemic and pulmonary involvement.

We present the case of a 45-year-old man who was admitted to the emergency service, with a history of renal transplantation from a cadaveric donor, he presented ACUTE RESPIRATORY DIFFICULTY SYNDROME (ARDS) and ventilatory failure due to infection by SARS-CoV-2. Also confirmed systemic infection by Cryptococcus neoformans without compromise of the central nervous system. Management was started with invasive mechanical ventilation, glucocorticoid, liposomal amphotericin B and he died 12 days after admission.
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