Toxic nephropathy: cocaine and its potent kidney damage
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street drugs, renal insufficiency, acute kidney tubular necrosis.

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Arias-Correal J, Arias-Correal S, Michelsen M, Orozco S, Pabón C, Cárdenas J, Charria J, Forero Y, Meneses A, Villate A. Toxic nephropathy: cocaine and its potent kidney damage. Rev. Colomb. Nefrol. [Internet]. 2020 Aug. 5 [cited 2024 Apr. 20];7(2). Available from:


In Colombia, the consumption of illicit substances increases daily. The increase and related consumption in the population involves both young people under 16 and young adults. Therefore, there are complications associated with the consumption of these substances that otherwise, would be unusual to find in this population group. In this case report, we will review how the use of cocaine led a young patient to the development acute kidney injury requiring renal replacement therapy, which in the histological
findings may correspond to rapidly progressive glomerulonephritis, or tubulointerstitial disease either acute renal tubular necrosis or acute interstitial nephritis.
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Colombia. Observatorio de Drogas de Colombia (ODC). Estudio de consumo de sustancias psicoactivas en el Sistema de Responsabilidad Penal para Adolescentes ( SRPA ) Colombia Resumen ejecutivo. Bogotá D.C.: ODC; 2018 [citado sep 20 2020]. Disponible en:

Colombia. Observatorio de Drogas de Colombia (ODC). Estudio nacional de consumo de sustancias psicoactivas en población escolar colombiana - 2016 [Internet]. Bogotá D.C.: (ODC); 2016[citado sep 20 2020]. Disponible en:

Pendergraft WF 3rd, Herlitz LC, Thornley-Brown D, Rosner M, Niles JL. Nephrotoxic Effects of Common and Emerging Drugs of Abuse. Clin J Am Soc Nephrol. 2014; 9(11):1996-2005 .

EE. UU. National INstitute on Drug Abuse. Cocaine Research Report. What is Cocaine?. Bethesda, MD: National Institutes of Health; 2016 [citado sep 29 2020]. Disponible en:

Pomara C, Cassano T, Errico SD, Bello S, Romano AD, Riezzo I, et al. Data Available on the Extent of Cocaine Use and Dependence?: Biochemistry , Phar- macologic Effects and Global Burden of Disease of Cocaine Abusers. Curr Med Chem. 2012;19(53):5647-57.

Warner M, Chen LH, Makuc DM, Anderson RN, Miniño AM. Drug poisoning deaths in the United States, 1980-2008. NCHS data brief. 2011;81(81):1-8.

Mansoor K, Kheetan M, Shahnawaz S, Shapiro AP, Patton-Tackett E, Dial L, et al. Systematic Review of nephrotoxicity of drugs abuse, 2005 - 2016. BMC Nephrology. 2017; 18:379-394.

Nanavati A, Herlitz LC. Tubulointerstitial Injury and Drugs of Abuse. Adv Chronic Kidney Dis. 2017;24(2):80-5.

Vongpatanasin W, Mansour Y, Chavoshan B, Arbique D, Victor RG. Cocaine Stimulates the Human Cardiovascular System via a Central Mechanism of Action. Circulation. 1999;100(5):497-502.

Valente MJ, Henrique R, Vilas-Boas V, Silva R, Bastos Mde L, Carvalho F, et al. Cocaine-induced kidney toxicity?: an in vitro study using primary cultured human proximal tubular epithelial cells. Arch Toxicol. 2012;86(2):249-61.

Valente MJ, Carvalho F, Bastos ML, de Pinho PG, Carvalho M. Contribution of Oxidative Metabolism to Cocaine-Induced Liver and Kidney Damage. Curr Med Chem.. 2012;19(33):5601-6.

Trouve R, Latour C, Nahas G. Cocaine and the renin-angiotensin system. Adv Biosci. 1991;80:165-76.

Mcgrath MM, Isakova T, Rennke HG, Mottola AM, Laliberte KA, Niles JL. Contaminated Cocaine and Antineutrophil Cytoplasmic Antibody-Associated Disease. Clin J Am Soc Nephrol. 2011;6(12):2799-805.

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