Sublingual vaccination with inactivated bacteria in recurrent urinary tract of nephrologic patients: experience in a center in Spain
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urinary tract infections, chronic kidney disease, bacterial vaccines.

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García Agudo R, Proy Vega B, Arias Arias Ángel, Panizo González N, Cazalla Cadenas F, Pereira Pérez EB, Redondo González O. Sublingual vaccination with inactivated bacteria in recurrent urinary tract of nephrologic patients: experience in a center in Spain. Rev. Colomb. Nefrol. [Internet]. 2020 Aug. 20 [cited 2023 Apr. 1];7(2). Available from:


Introduction: Urinary tract infections (UTIs) are common in patients with chronic kidney disease. A treatment option in recurrent UTI is sublingual bacterial vaccination. The objective of this study was to determine the response to vaccination in nephrologic patients with recurrent UTI.

Method: Quasi-experimental study before-after (15 months) in patients with recurrent UTI from the outpatient nephrology consultation. After receiving antibiotic treatment for each UTI, patients took one cycle of the sublingual bacterial vaccine Uromune? for three months. Sociodemographic data, associated risk factors, analysis, UTI in the previous and subsequent six months, microorganisms, concomitant antibiotic treatment, response to treatment and resolution of UTI were collected.

Results: Twenty-six patients (80.8% female) of 61.9 ? 18.4 years, 46.2% with diabetes and 47.7% with impaired renal function were included. The episodes of UTI were 3.62 ? 1.77 (1-7) before and 1.69 ? 1.62 (0-5) after vaccination. In total, 184 urine cultures were collected: 74.9% positive, 16.9% negative and 8.2% contaminated. The most frequent bacteria were Escherichia coli (55.4%), Enterococcus faecalis (6%) and Enterobacter cloacae (2.7%). Fifty percent had voiding syndrome, which was inversely associated with age (p < 0.05); 26.9% did not have a UTI again and 73.1% had fewer episodes. Patients with advanced chronic disease (stages 4-5) reponded worse to the vaccine (92.9% vs 50%, p =0.025).

Conclusions: Sublingual bacterial vaccination is a good treatment option in recurrent UTI of nephrologic patients, being more effective in those with better renal function.
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