Cyclooxygenase biology in renal function – literature review
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cyclooxygenase 1
cyclooxygenase 2
anti-Inflammatory agents

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Goetz Moro M, Vargas Sanchez PK, Lupepsa AC, Baller EM, Nobre Franco GC. Cyclooxygenase biology in renal function – literature review. Rev. Colomb. Nefrol. [Internet]. 2017 Feb. 7 [cited 2024 Jul. 25];4(1):27-3. Available from:


The cyclooxygenase (COX) exists in two main isoforms, COX-1 and COX-2, which are present in the renal system to ensure its homeostasis. However, in different clinical situations, these enzymes can play a physiologic role in maintaining the integrity of this organ, and also be associated with the worsening of tissue injuries/damage. In this sense, an explanation of the true biological function of the isoforms of COX enables a better understanding of the physiology and pathology of the kidney, as well as a better understanding of the consequences of its inhibition by the use of drugs. This review aimed to study the biological role of the COX enzyme in the renal system in different clinical situations.
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