Keywords
Rapidly progressive glomerulonephritis
extracapillary proliferation
lymphoma
neoplasia
extracapillary proliferation
lymphoma
neoplasia
How to Cite
1.
Cabarcas B O, Calderón P L, Gaviria J L, Rodelo C J, Arias R L. Pauci-immune glomerulonephritis with extracapillary proliferation; An unusual paraneoplastic manifestation associated with Mantle Cell Lymphoma (B). Rev. Colomb. Nefrol. [Internet]. 2015 Apr. 7 [cited 2024 Apr. 20];2(1):56-62. Available from: https://revistanefrologia.org/index.php/rcn/article/view/197
Abstract
The relationship between neoplasia and secondary renal involvement is increasing. Membranous glomerulonephritis is the main cause of nephrotic syndrome, associated with solid tumors, and less frequently hematologic neoplasia. Hodgkin’s lymphoma is the hematologic neoplasia most closely associated with minimal change disease. However, there are case reports that describe a relationship with non-Hodgkin’s lymphomas and leukemias. The usual clinical manifestation is the nephrotic syndrome,which may precede for several months or coexist with the diagnosis of lymphoma. Its pathophysiology is not very clear. It is suggested that it is related to T lymphocyte dysfunction. In addition, there are reports of thrombotic microangiopathy, related to the use of biological therapy and antineoplastic agents.Rapidly progressive glomerulonephritis is a clinical syndrome associated with glomerular extracapillary proliferation, usually related to vasculitis associated with ANCA and vasculitis mediated by immunocomplexes. Neoplasias are also related to a large number of vasculopathies. Glomerulonephritis with extracapillary proliferation are much more common in malignant solid tumors. In addition, associations with myelodysplastic syndrome, chronic lymphocytic leukemia and Hodgking lymphoma have been reported. The association between Mantle Cell B lymphomas and glomerulonephritis with extracapillary proliferation is unusual. The following is a case of a patient diagnosed with Mantle Cell B lymphoma who has a rapidly progressive glomerulonephritis secondary to extracapillary, necrotizing and pauci-immune proliferative lesions.
References
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8. Jennette, J.C., et al., 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum.2013;65(1):1-11.
9. Greer, J.M., et al., Vasculitis associated with malignancy. Experience with 13 patients and literature review. Medicine
(Baltimore). 1988;67(4):220-30.
10. Navarro, J.F., et al., Anti-neutrophil cytoplasmic antibody-associated paraneoplastic vasculitis. Postgrad Med J. 1994;70(823):373-5.
11. Bacchetta, J., et al., Paraneoplastic glomerular diseases and malignancies. Crit Rev Oncol Hematol. 2009;70(1):39- 58.
12. Bogdanovic, R., et al., Glomerular involvement in myelodysplastic syndromes. Pediatr Nephrol. 2001;16(12):1053-7.
13. Wen, Y.K. and K.I. Wen, Rapidly progressive glomerulonephritis as a presenting feature of chronic lymphocytic leukemia. Int Urol Nephrol. 2014;46(1):217-21.
14. Barbour, T.D., et al., Simultaneous necrotizing glomerulonephritis and Hodgkin’s lymphoma: a case report and review of the literature. Nephrol Dial Transplant. 2011;26(10):3403-8.
15. Karim, M., et al., Proliferative glomerulonephritis associated with mantle cell lymphoma--natural history and effect of treatment in 2 cases. Clin Nephrol. 2004;61(6):422-8.
2. Audard, V., et al., Minimal change nephrotic syndrome and classical Hodgkin’s lymphoma: report of 21 cases and review of the literature. Kidney Int. 2006;69(12):2251-60.
3. Powderly, W.G., et al., Renal glomerulopathies associated with Hodgkin’s disease. Cancer. 1985;56(4):874-5.
4. Da’as, N., et al., Kidney involvement and renal manifestations in non-Hodgkin’s lymphoma and lymphocytic leukemia: a retrospective study in 700 patients. Eur J Haematol. 2001;67(3):158-64.
5. Jhaveri, K.D., et al., Glomerular diseases associated with cancer, chemotherapy, and hematopoietic stem cell transplantation. Adv Chronic Kidney Dis. 2014;21(1):48-55.
6. Perazella, M.A., Onco-nephrology: renal toxicities of chemotherapeutic agents. Clin J Am Soc Nephrol. 2012;7(10):1713-21.
7. Perazella, M.A. and G.W. Moeckel, Nephrotoxicity from chemotherapeutic agents: clinical manifestations, pathobiology,
and prevention/therapy. Semin Nephrol. 2010;30(6):570-81.
8. Jennette, J.C., et al., 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum.2013;65(1):1-11.
9. Greer, J.M., et al., Vasculitis associated with malignancy. Experience with 13 patients and literature review. Medicine
(Baltimore). 1988;67(4):220-30.
10. Navarro, J.F., et al., Anti-neutrophil cytoplasmic antibody-associated paraneoplastic vasculitis. Postgrad Med J. 1994;70(823):373-5.
11. Bacchetta, J., et al., Paraneoplastic glomerular diseases and malignancies. Crit Rev Oncol Hematol. 2009;70(1):39- 58.
12. Bogdanovic, R., et al., Glomerular involvement in myelodysplastic syndromes. Pediatr Nephrol. 2001;16(12):1053-7.
13. Wen, Y.K. and K.I. Wen, Rapidly progressive glomerulonephritis as a presenting feature of chronic lymphocytic leukemia. Int Urol Nephrol. 2014;46(1):217-21.
14. Barbour, T.D., et al., Simultaneous necrotizing glomerulonephritis and Hodgkin’s lymphoma: a case report and review of the literature. Nephrol Dial Transplant. 2011;26(10):3403-8.
15. Karim, M., et al., Proliferative glomerulonephritis associated with mantle cell lymphoma--natural history and effect of treatment in 2 cases. Clin Nephrol. 2004;61(6):422-8.
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