Pauci-immune glomerulonephritis with extracapillary proliferation; An unusual paraneoplastic manifestation associated with Mantle Cell Lymphoma (B)
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Keywords

Rapidly progressive glomerulonephritis
extracapillary proliferation
lymphoma
neoplasia

How to Cite

1.
Cabarcas B O, Calderón P L, Gaviria J L, Rodelo C J, Arias R L. Pauci-immune glomerulonephritis with extracapillary proliferation; An unusual paraneoplastic manifestation associated with Mantle Cell Lymphoma (B). Rev. Colomb. Nefrol. [Internet]. 2015 Apr. 7 [cited 2024 Jul. 15];2(1):56-62. Available from: https://revistanefrologia.org/index.php/rcn/article/view/197

Abstract

The relationship between neoplasia and secondary renal involvement is increasing. Membranous glomerulonephritis is the main cause of nephrotic syndrome, associated with solid tumors, and less frequently hematologic neoplasia. Hodgkin’s lymphoma is the hematologic neoplasia most closely associated with minimal change disease. However, there are case reports that describe a relationship with non-Hodgkin’s lymphomas and leukemias. The usual clinical manifestation is the nephrotic syndrome,which may precede for several months or coexist with the diagnosis of lymphoma. Its pathophysiology is not very clear. It is suggested that it is related to T lymphocyte dysfunction. In addition, there are reports of thrombotic microangiopathy, related to the use of biological therapy and antineoplastic agents.
Rapidly progressive glomerulonephritis is a clinical syndrome associated with glomerular extracapillary proliferation, usually related to vasculitis associated with ANCA and vasculitis mediated by immunocomplexes. Neoplasias are also related to a large number of vasculopathies. Glomerulonephritis with extracapillary proliferation are much more common in malignant solid tumors. In addition, associations with myelodysplastic syndrome, chronic lymphocytic leukemia and Hodgking lymphoma have been reported. The association between Mantle Cell B lymphomas and glomerulonephritis with extracapillary proliferation is unusual. The following is a case of a patient diagnosed with Mantle Cell B lymphoma who has a rapidly progressive glomerulonephritis secondary to extracapillary, necrotizing and pauci-immune proliferative lesions.
https://doi.org/10.22265/acnef.2.1.197
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References

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