Conversion of calcineurin inhibitors by mTOR inhibitors contributes to the treatment of intraepithelial neoplasms in the cervix in women with renal transplantation
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Keywords

Tacrolimus. Everolimus. Intraepithelial cervical neoplasia. Human papilloma virus.

How to Cite

1.
Lafuente Covarrubias O, Sánchez Sobrino B, Zalamea Jarin F, Portolés Pérez J. Conversion of calcineurin inhibitors by mTOR inhibitors contributes to the treatment of intraepithelial neoplasms in the cervix in women with renal transplantation. Rev. Colomb. Nefrol. [Internet]. 2014 Jul. 1 [cited 2024 Apr. 20];1(2):130-3. Available from: https://revistanefrologia.org/index.php/rcn/article/view/184

Abstract

The patient is a 32-year-old woman with a history of chronic kidney disease due to interstitial nephritis. After 2 years on hemodialysis the patient received a renal transplant and was treated with standard immunosuppression: steroids, mycophenolate mofetil and tacrolimus. Three years later the patient presented a squamous intraepithelial neoplasia in the cervix and infection with human papilloma virus (HPV), with poor response to local treatment with cryotherapy and laser. Because calcineurin inhibitors have a higher risk of presenting cancer such as non-Hodgkin’s lymphoma and skin cancer, and because inhibitors of the mammalian target of rapamycin (mTOR) at the intracellular level could reverse premalignant skin tumor lesions in the head and neck, tacrolimus, was suspended and changed to everolimus, an mTOR inhibitor. As a result, both cervical lesion and HPV infection disappeared 6 years later, with a fair renal function and no episodes of renal graft rejection.
https://doi.org/10.22265/acnef.1.2.184
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References

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