TY - JOUR AU - Torres S., Rodolfo AU - Rosselli , Carlos AU - Olivares , Carlos AU - Olivares, Orlando AU - Rumpf, Paola M. AU - Pulido Medina, Cristian PY - 2021/05/27 Y2 - 2024/03/28 TI - High transtubular grandient hypokalemia: clinical case and a practical proposal for its approach JF - Revista Colombiana de Nefrología JA - Rev. Colomb. Nefrol. VL - 8 IS - 2 SE - Clinical Case DO - 10.22265/acnef.8.2.498 UR - https://revistanefrologia.org/index.php/rcn/article/view/498 SP - e498 AB - <p>Potassium is a predominantly intracelular ion involved in multiple essential functions to maintain celular homeostasis. Therefore, its variations at the plasma level are tightly regulated by the renal and endocrine systems; in addition to being affected by situations such as acidosis, changes in plasma osmolality and concentration of another electrolytes. Hypokalemia is a common electrolyte disorder in clinical practice affected by reporting excessive damage or loss. Its diagnostic approach requires a complete medical history that includes personal pathological and pharmacological history, a specific physical examination with certain conditions like patient´s blood volume and hydration status, as well as the measurement of other electrolytes at the plasma level and occasionally in urine. The thanstubuar potassium gradient is a useful tool to address posible causes. Bartter síndrome is one of the causes of elevated transtubular gradient hypokalemia. </p> ER -