@article{Rico Fontalvo_Montejo Hernández_Daza Arnedo_Cabrales_2022, title={Additional Considerations in the Treatment of Diabetic Nephropathy Based on the KDOQI Clinical Practice Guideline }, volume={9}, url={https://revistanefrologia.org/index.php/rcn/article/view/602}, DOI={10.22265/acnef.9.3.602}, abstractNote={<p>Obesity is a risk factor for the development and progression of CKD, which has been shown in numerous studies. The mechanism of how this occurs is not completely understood, but several putative mechanisms proposed via adiposity, include low adiponectin high leptin and resistin, causing inflammation, insulin resistance, RAAS activation and oxidative stress, leading to CKD; in addition, it also causes diabetes mellitus, hypertension, and cardiovascular disease. Obesity is a persistent inflammatory state, and inflammation has been shown to play an important role in the development and progression of diabetic kidney disease, hence controlling obesity has become a key component as a preventative strategy in the development of kidney disease.</p> <p> </p>}, number={3}, journal={Revista Colombiana de Nefrología}, author={Rico Fontalvo, Jorge and Montejo Hernández, Juan David and Daza Arnedo, Rodrigo and Cabrales, Jose}, year={2022}, month={Oct.} }