Obesidad y enfermedad renal: consecuencias ocultas de la epidemia

Csaba P. , MD Kovesdy, Susan Furth, Carmine Zoccali

Resumen


La obesidad se ha convertido en una epidemia mundial, y se ha proyectado que su prevalencia se incrementará en un 40 % en la próxima década. Esta creciente prevalencia supone implicaciones tanto para el riesgo de desarrollo de diabetes y enfermedades cardiovasculares como para el desarrollo de Enfermedad Renal Crónica. Un elevado índice de masa corporal es uno de los factores de riesgo más importantes para el desarrollo de Enfermedad Renal Crónica. En individuos afectados por la obesidad, tiene lugar una hiperfiltración compensatoria necesaria para alcanzar la alta demanda metabólica secundaria al aumento del peso corporal. El incremento de la presión intraglomerular puede generar daño renal y elevar el riesgo de desarrollar Enfermedad Renal Crónica a largo plazo. La incidencia de glomerulopatía asociada a obesidad se ha incrementado 10 veces en los últimos años. Así mismo se ha demostrado que la obesidad es un factor de riesgo para el desarrollo de nefrolitiasis y un número de neoplasias, incluyendo cáncer renal. Este año, el Día Mundial del Riñón promueve la educación a cerca de las consecuencias nocivas de la obesidad y su asociación con la enfermedad renal, abogando por un estilo de vida saludable y la implementación de políticas públicas de salud que promuevan medidas preventivas alcanzables.

Palabras clave


obesidad, enfermedad renal crónica, nefrolitiasis, cáncer renal, prevención

Referencias


Forouzanfar MH, Alexander L, Anderson HR, Bachman VF, Biryukov S, Brauer M, Burnett R, et al. RA: Global,

regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic

risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease

Study 2013. Lancet 386:2287-2323, 2015

Flegal KM, Kruszon-Moran D, Carroll MD, Fryar CD, Ogden CL: Trends in Obesity Among Adults in the United States, 2005 to 2014. JAMA 315:2284-2291, 2016

Cattaneo A, Monasta L, Stamatakis E, Lioret S, Castetbon K, Frenken F, Manios Y, Moschonis G, Savva S, Zaborskis A, Rito AI, Nanu M, Vignerova J, Caroli M, Ludvigsson J, Koch FS, Serra-Majem L, Szponar L, van LF, Brug J: Overweight and obesity in infants and pre-school children in the European Union: a review of existing data. Obes Rev 11:389-398, 2010

Olaya B, Moneta MV, Pez O, Bitfoi A, Carta MG, Eke C, Goelitz D, Keyes KM, Kuijpers R, Lesinskiene S, Mihova Z, Otten R, Fermanian C, Haro JM, Kovess V: Country-level and individual correlates of overweight and obesity among primary school children: a cross-sectional study in seven European countries. BMC Public Health 15:475, 2015

Subramanian SV, Perkins JM, Ozaltin E, Davey SG: Weight of nations: a socioeconomic analysis of women in low- to middle-income countries. Am J Clin Nutr 93:413-421, 2011

Tsujimoto T, Sairenchi T, Iso H, Irie F, Yamagishi K, Watanabe H, Tanaka K, Muto T, Ota H: The dose-response relationship between body mass index and the risk of incident stage >/=3 chronic kidney disease in a general japanese population: the Ibaraki prefectural health study (IPHS). J Epidemiol 24:444-451, 2014

Elsayed EF, Sarnak MJ, Tighiouart H, Griffith JL, Kurth T, Salem DN, Levey AS, Weiner DE: Waist-to-hip ratio, body mass index, and subsequent kidney disease and death. Am J Kidney Dis 52:29-38, 2008

Pinto-Sietsma SJ, Navis G, Janssen WM, de ZD, Gans RO, de Jong PE: A central body fat distribution is related to renal function impairment, even in lean subjects. Am J Kidney Dis 41:733-741, 2003

Foster MC, Hwang SJ, Larson MG, Lichtman JH, Parikh NI, Vasan RS, Levy D, Fox CS: Overweight, obesity, and the development of stage 3 CKD: the Framingham Heart Study. Am J Kidney Dis 52:39-48, 2008

Kramer H, Luke A, Bidani A, Cao G, Cooper R, McGee D: Obesity and prevalent and incident CKD: the Hypertension Detection and Follow-Up Program. Am J Kidney Dis 46:587-594, 2005

Chang A, Van HL, Jacobs DR, Jr., Liu K, Muntner P, Newsome B, Shoham DA, Durazo-Arvizu R, Bibbins-Domingo K, Reis J, Kramer H: Lifestyle-related factors, obesity, and incident microalbuminuria: the CARDIA (Coronary Artery Risk Development in Young Adults) study. Am J Kidney Dis 62:267-275, 2013

Ejerblad E, Fored CM, Lindblad P, Fryzek J, McLaughlin JK, Nyren O: Obesity and risk for chronic renal failure. J Am Soc Nephrol 17:1695-1702, 2006

Gelber RP, Kurth T, Kausz AT, Manson JE, Buring JE, Levey AS, Gaziano JM: Association between body mass index and CKD in apparently healthy men. Am J Kidney Dis 46:871-880, 2005

Lu JL, Molnar MZ, Naseer A, Mikkelsen MK, Kalantar-Zadeh K, Kovesdy CP: Association of age and BMI with kidney function and mortality: a cohort study. Lancet Diabetes Endocrinol 3:704-714, 2015

Munkhaugen J, Lydersen S, Wideroe TE, Hallan S: Prehypertension, obesity, and risk of kidney disease: 20-year follow-up of the HUNT I study in Norway. Am J Kidney Dis 54:638-646, 2009

Iseki K, Ikemiya Y, Kinjo K, Inoue T, Iseki C, Takishita S: Body mass index and the risk of development of end-stage renal disease in a screened cohort. Kidney Int 65:1870-1876, 2004

Vivante A, Golan E, Tzur D, Leiba A, Tirosh A, Skorecki K, Calderon-Margalit R: Body mass index in 1.2 million adolescents and risk for end-stage renal disease. Arch Intern Med 172:1644-1650, 2012

Hsu C, McCulloch C, Iribarren C, Darbinian J, Go A: Body mass index and risk for end-stage renal disease. Ann Intern Med 144:21-28, 2006

Lu JL, Kalantar-Zadeh K, Ma JZ, Quarles LD, Kovesdy CP: Association of body mass index with outcomes in patients with CKD. J Am Soc Nephrol 25:2088- 2096, 2014

Thoenes M, Reil JC, Khan BV, Bramlage P, Volpe M, Kirch W, Bohm M: Abdominal obesity is associated with microalbuminuria and an elevated cardiovascular risk profile in patients with hypertension. Vasc Health Risk Manag 5:577-585, 2009

Kramer H, Gutierrez OM, Judd SE, Muntner P, Warnock DG, Tanner RM, Panwar B, Shoham DA, McClellan W: Waist Circumference, Body Mass Index, and ESRD in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) Study. Am J Kidney Dis 67:62-69, 2016

Foster MC, Hwang SJ, Massaro JM, Hoffmann U, DeBoer IH, Robins SJ, Vasan RS, Fox CS: Association of subcutaneous and visceral adiposity with

albuminuria: the Framingham Heart Study. Obesity (Silver Spring) 19:1284-1289, 2011

Postorino M, Marino C, Tripepi G, Zoccali C: Abdominal obesity and all-cause and cardiovascular mortality in end-stage renal disease. J Am Coll Cardiol 53:1265-1272, 2009

Kovesdy CP, Czira ME, Rudas A, Ujszaszi A, Rosivall L, Novak M, Kalantar- Zadeh K, Molnar MZ, Mucsi I: Body mass index, waist circumference and mortality in kidney transplant recipients. Am J Transplant 10:2644-2651, 2010

Scales CD, Jr., Smith AC, Hanley JM, Saigal CS: Prevalence of kidney stones in the United States. Eur Urol 62:160-165, 2012

Curhan GC, Willett WC, Rimm EB, Speizer FE, Stampfer MJ: Body size and risk of kidney stones. J Am Soc Nephrol 9:1645-1652, 1998

Taylor EN, Stampfer MJ, Curhan GC: Obesity, weight gain, and the risk of kidney stones. JAMA 293:455-462, 2005

Bhaskaran K, Douglas I, Forbes H, dos-Santos-Silva I, Leon DA, Smeeth L: Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5.24 million UK adults. Lancet 384:755-765, 2014

Arnold M, Pandeya N, Byrnes G, Renehan AG, Stevens GA, Ezzati M, Ferlay J, Miranda JJ, Romieu I, Dikshit R, Forman D, Soerjomataram I: Global burden of cancer attributable to high body-mass index in 2012: a population-based study. Lancet Oncol 16:36-46, 2015

Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M: Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371:569-578, 2008

Bluher M: The distinction of metabolically 'healthy' from 'unhealthy' obese individuals. Curr Opin Lipidol 21:38-43, 2010

Sharma K: The link between obesity and albuminuria: adiponectin and podocyte dysfunction. Kidney Int 76:145-148, 2009

Wolf G, Ziyadeh FN: Leptin and renal fibrosis. Contrib Nephrol 151:175-183, 2006

Ellington AA, Malik AR, Klee GG, Turner ST, Rule AD, Mosley TH, Jr., Kullo IJ: Association of plasma resistin with glomerular filtration rate and albuminuria in hypertensive adults. Hypertension 50:708-714, 2007

Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve B: Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 17:4-12, 2006

Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, Nakayama O, Makishima M, Matsuda M, Shimomura I: Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114:1752- 1761, 2004

Ruan XZ, Varghese Z, Moorhead JF: An update on the lipid nephrotoxicity hypothesis. Nat Rev Nephrol 5:713-721, 2009

Ruster C, Wolf G: The role of the renin-angiotensin-aldosterone system in obesity-related renal diseases. Semin Nephrol 33:44-53, 2013

Oterdoom LH, de Vries AP, Gansevoort RT, de Jong PE, Gans RO, Bakker SJ: Fasting insulin modifies the relation between age and renal function. Nephrol Dial Transplant 22:1587-1592, 2007

Reaven GM: Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 37:1595-1607, 1988

Kambham N, Markowitz GS, Valeri AM, Lin J, D'Agati VD: Obesity-related glomerulopathy: an emerging epidemic. Kidney Int 59:1498-1509, 2001

de Vries AP, Ruggenenti P, Ruan XZ, Praga M, Cruzado JM, Bajema IM, D'Agati VD, Lamb HJ, Pongrac BD, Hojs R, Abbate M, Rodriquez R, Mogensen CE, Porrini E: Fatty kidney: emerging role of ectopic lipid in obesity-related renal disease. Lancet Diabetes Endocrinol 2:417-426, 2014

Foster MC, Hwang SJ, Porter SA, Massaro JM, Hoffmann U, Fox CS: Fatty kidney, hypertension, and chronic kidney disease: the Framingham Heart Study. Hypertension 58:784-790, 2011

Henegar JR, Bigler SA, Henegar LK, Tyagi SC, Hall JE: Functional and structural changes in the kidney in the early stages of obesity. J Am Soc Nephrol 12:1211- 1217, 2001

Knight SF, Quigley JE, Yuan J, Roy SS, Elmarakby A, Imig JD: Endothelial dysfunction and the development of renal injury in spontaneously hypertensive rats fed a high-fat diet. Hypertension 51:352-359, 2008

Tsuboi N, Utsunomiya Y, Kanzaki G, Koike K, Ikegami M, Kawamura T, Hosoya T: Low glomerular density with glomerulomegaly in obesity-related glomerulopathy. Clin J Am Soc Nephrol 7:735-741, 2012

Ribstein J, du CG, Mimran A: Combined renal effects of overweight and hypertension. Hypertension 26:610-615, 1995

Maalouf NM, Sakhaee K, Parks JH, Coe FL, Adams-Huet B, Pak CY: Association of urinary pH with body weight in nephrolithiasis. Kidney Int 65:1422-1425, 2004

Lemann J, Jr., Pleuss JA, Worcester EM, Hornick L, Schrab D, Hoffmann RG: Urinary oxalate excretion increases with body size and decreases with increasing dietary calcium intake among healthy adults. Kidney Int 49:200-208, 1996

Siener R, Glatz S, Nicolay C, Hesse A: The role of overweight and obesity in calcium oxalate stone formation. Obes Res 12:106-113, 2004

Taylor EN, Stampfer MJ, Curhan GC: Diabetes mellitus and the risk of nephrolithiasis. Kidney Int 68:1230-1235, 2005

Klisic J, Hu MC, Nief V, Reyes L, Fuster D, Moe OW, Ambuhl PM: Insulin activates Na(+)/H(+) exchanger 3: biphasic response and glucocorticoid dependence. Am J Physiol Renal Physiol 283:F532-F539, 2002

Chobanian MC, Hammerman MR: Insulin stimulates ammoniagenesis in canine renal proximal tubular segments. Am J Physiol 253:F1171-F1177, 1987

Daudon M, Lacour B, Jungers P: Influence of body size on urinary stone composition in men and women. Urol Res 34:193-199, 2006

Sinha MK, Collazo-Clavell ML, Rule A, Milliner DS, Nelson W, Sarr MG, Kumar R, Lieske JC: Hyperoxaluric nephrolithiasis is a complication of Roux-en-Y gastric bypass surgery. Kidney Int 72:100-107, 2007

Calle EE, Kaaks R: Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4:579-591, 2004

Dalamaga M, Diakopoulos KN, Mantzoros CS: The role of adiponectin in cancer: a review of current evidence. Endocr Rev 33:547-594, 2012

Lamas O, Marti A, Martinez JA: Obesity and immunocompetence. Eur J Clin Nutr 56 Suppl 3:S42-S45, 2002

Lim C, Savan R: The role of the IL-22/IL-22R1 axis in cancer. Cytokine Growth Factor Rev 25:257-271, 2014

Grivennikov SI, Greten FR, Karin M: Immunity, inflammation, and cancer. Cell 140:883-899, 2010

Kovesdy CP, Anderson JE, Kalantar-Zadeh K: Paradoxical association between body mass index and mortality in men with CKD not yet on dialysis. Am J Kidney Dis 49:581-591, 2007

Kalantar-Zadeh K, Kuwae N, Wu DY, Shantouf RS, Fouque D, Anker SD, Block G, Kopple JD: Associations of body fat and its changes over time with quality of

life and prospective mortality in hemodialysis patients. Am J Clin Nutr 83:202- 210, 2006

Beddhu S, Pappas LM, Ramkumar N, Samore M: Effects of body size and body composition on survival in hemodialysis patients. J Am Soc Nephrol 14:2366- 2372, 2003

Curtis JP, Selter JG, Wang Y, Rathore SS, Jovin IS, Jadbabaie F, Kosiborod M, Portnay EL, Sokol SI, Bader F, Krumholz HM: The obesity paradox: body mass index and outcomes in patients with heart failure. Arch Intern Med 165:55-61, 2005

Wilson DO, Rogers RM, Wright EC, Anthonisen NR: Body weight in chronic obstructive pulmonary disease. The National Institutes of Health Intermittent Positive-Pressure Breathing Trial. Am Rev Respir Dis 139:1435-1438, 1989

Escalante A, Haas RW, del R, I: Paradoxical effect of body mass index on survival in rheumatoid arthritis: role of comorbidity and systemic inflammation. Arch Intern Med 165:1624-1629, 2005

Kalantar-Zadeh K, Kilpatrick RD, Kuwae N, Wu DY: Reverse epidemiology: a spurious hypothesis or a hardcore reality? Blood Purif 23:57-63, 2005

Noori N, Kopple JD, Kovesdy CP, Feroze U, Sim JJ, Murali SB, Luna A, Gomez M, Luna C, Bross R, Nissenson AR, Kalantar-Zadeh K: Mid-arm muscle circumference and quality of life and survival in maintenance hemodialysis patients. Clin J Am Soc Nephrol 5:2258-2268, 2010

Dekker FW, de MR, van Dijk PC, Zoccali C, Jager KJ: Survival analysis: time- dependent effects and time-varying risk factors. Kidney Int 74:994-997, 2008

Snyder JJ, Foley RN, Gilbertson DT, Vonesh EF, Collins AJ: Body size and outcomes on peritoneal dialysis in the United States. Kidney Int 64:1838-1844, 2003

Lee PS, Sampath K, Karumanchi SA, Tamez H, Bhan I, Isakova T, Gutierrez OM, Wolf M, Chang Y, Stossel TP, Thadhani R: Plasma gelsolin and circulating actin correlate with hemodialysis mortality. J Am Soc Nephrol 20:1140-1148, 2009

Horwich TB, Fonarow GC, Hamilton MA, MacLellan WR, Woo MA, Tillisch JH: The relationship between obesity and mortality in patients with heart failure. J Am Coll Cardiol 38:789-795, 2001

Stenvinkel P, Marchlewska A, Pecoits-Filho R, Heimburger O, Zhang Z, Hoff C, Holmes C, Axelsson J, Arvidsson S, Schalling M, Barany P, Lindholm B, Nordfors L: Adiponectin in renal disease: relationship to phenotype and genetic variation in the gene encoding adiponectin. Kidney Int 65:274-281, 2004

Mohamed-Ali V, Goodrick S, Bulmer K, Holly JM, Yudkin JS, Coppack SW: Production of soluble tumor necrosis factor receptors by human subcutaneous adipose tissue in vivo. Am J Physiol 277:E971-E975, 1999

Rauchhaus M, Coats AJ, Anker SD: The endotoxin-lipoprotein hypothesis. Lancet 356:930-933, 2000

Jandacek RJ, Anderson N, Liu M, Zheng S, Yang Q, Tso P: Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene. Am J Physiol Gastrointest Liver Physiol 288:G292-G299, 2005

Kramer HJ, Saranathan A, Luke A, Durazo-Arvizu RA, Guichan C, Hou S, Cooper R: Increasing body mass index and obesity in the incident ESRD population. J Am Soc Nephrol 17:1453-1459, 2006

Postorino M, Mancini E, D'Arrigo G, Marino C, Vilasi A, Tripepi G, Gallus S, Lugo A, Santoro A, Zoccali C: Body mass index trend in haemodialysis patients: the shift of nutritional disorders in two Italian regions. Nephrol Dial Transplant 2016

2008-2013 Action Plan for the Global Strategy for the Prevention and Control of Noncommunicable Diseases. 2009. World Health Organization.

Ref Type: Online Source

O'Donoghue DJ, Stevens PE: A decade after the KDOQI CKD/guidelines: a perspective from the United Kingdom. Am J Kidney Dis 60:740-742, 2012

Bolignano D, Zoccali C: Effects of weight loss on renal function in obese CKD patients: a systematic review. Nephrol Dial Transplant 28 Suppl 4:iv82-iv98, 2013

Chang Y, Ryu S, Choi Y, Zhang Y, Cho J, Kwon MJ, Hyun YY, Lee KB, Kim H, Jung HS, Yun KE, Ahn J, Rampal S, Zhao D, Suh BS, Chung EC, Shin H, Pastor-Barriuso R, Guallar E: Metabolically Healthy Obesity and Development of Chronic Kidney Disease: A Cohort Study. Ann Intern Med 164:305-312, 2016

Wing RR, Bolin P, Brancati FL, Bray GA, Clark JM, Coday M, Crow RS, Curtis JM, Egan CM, Espeland MA, Evans M, Foreyt JP, Ghazarian S, Gregg EW, Harrison B, Hazuda HP, Hill JO, Horton ES, Hubbard VS, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Kitabchi AE, Knowler WC, Lewis CE, Maschak- Carey BJ, Montez MG, Murillo A, Nathan DM, Patricio J, Peters A, Pi-Sunyer X, Pownall H, Reboussin D, Regensteiner JG, Rickman AD, Ryan DH, Safford M, Wadden TA, Wagenknecht LE, West DS, Williamson DF, Yanovski SZ: Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med 369:145-154, 2013

Mallamaci F, Ruggenenti P, Perna A, Leonardis D, Tripepi R, Tripepi G, Remuzzi G, Zoccali C: ACE inhibition is renoprotective among obese patients with proteinuria. J Am Soc Nephrol 22:1122-1128, 2011

Friedman AN, Wolfe B: Is Bariatric Surgery an Effective Treatment for Type II Diabetic Kidney Disease? Clin J Am Soc Nephrol 11:528-535, 2016

Chang AR, Chen Y, Still C, Wood GC, Kirchner HL, Lewis M, Kramer H, Hartle JE, Carey D, Appel LJ, Grams ME: Bariatric surgery is associated with improvement in kidney outcomes. Kidney Int 90:164-171, 2016

Jamal MH, Corcelles R, Daigle CR, Rogula T, Kroh M, Schauer PR, Brethauer SA: Safety and effectiveness of bariatric surgery in dialysis patients and kidney transplantation candidates. Surg Obes Relat Dis 11:419-423, 2015

Ahmadi SF, Zahmatkesh G, Ahmadi E, Streja E, Rhee CM, Gillen DL, De NL, Minutolo R, Ricardo AC, Kovesdy CP, Kalantar-Zadeh K: Association of Body Mass Index with Clinical Outcomes in Non-Dialysis-Dependent Chronic Kidney Disease: A Systematic Review and Meta-Analysis. Cardiorenal Med 6:37-49, 2015


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DOI: 10.22265/acnef.4.1.262

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