Bisfenol (A) una toxina a tener en cuenta en el enfermo renal en hemodiálisis

Enrique Bosch Panadero, Sebastian Mas Fontao, Alberto Ruiz Priego, Jesús Egido, Emilio González Parra

Resumen


Muchas toxinas urémicas son originadas como consecuencia del catabolismo proteico por la flora intestinal. El metabolismo de aminoácidos aromáticos origina residuos de tipo fenólico. De estas toxinas, la más estudiada es el p-cresol, que se asocia a la función renal y daño vascular. El Bisfenol A (BPA) es una molécula exógena de características semejantes a estas toxinas urémicas aromáticas. El BPA es un disruptor endocrino estrogénico que se encuentra en latas de conserva, botellas de plástico, resinas epoxi y en algunos dializadores. Esta molécula se acumula en pacientes que tienen deteriorada la función renal. Estudios observacionales han demostrado que una exposición a BPA está vinculada, entre otras muchas, a lesión renal y cardiovascular en los seres humanos; en estudios en animales se ha descrito un vínculo causal. Los riñones con función renal normal excretan rápidamente BPA, pero una excreción insuficiente en pacientes con ERC da lugar a la acumulación del BPA en el organismo.

Palabras clave


toxina urémica, bisfenol A, enfermedad crónica renal, disruptor endocrino, hemodiálisis.

Referencias


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DOI: 10.22265/acnef.4.1.256

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