Daño renal asociado a metales pesados: trabajo de revisión

Juan Daniel Díaz García, Emmanuel Arceo

Resumen


La enfermedad renal crónica (ERC) representa un importante problema de salud en todo el globo. Actualmente, es esencial para su prevención el conocimiento de los factores ambientales asociados con la enfermedad. Se reconocen diversos metales pesados, entre los que destacan el cadmio (Cd), plomo (Pb), arsénico (As) y mercurio (Hg), que están claramente asociados con la lesión renal y la progresión de la ERC. Estudios en animales y humanos demuestran, principalmente, una clara asociación entre la exposición a estos metales y la presencia de daño renal crónico, donde la fisiopatología de cada uno de ellos es importante para entender el mecanismo de daño renal. La presente revisión tiene como objetivo analizar, tanto la fisiopatología y manifestaciones clínicas de la nefrotoxicidad asociada a dichos metales, como los diferentes estudios que se han realizado en humanos y animales.

 


Palabras clave


Nefrotoxicidad, cadmio, plomo, arsénico, mercurio, necrosis tubular aguda, enfermedad renal crónica, metales pesados.

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DOI: 10.22265/acnef.5.2.254

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